Results 101 to 110 of about 209,934 (286)

ARABIDOPSIS HOMOLOG OF TRITHORAX1 impacts lateral root development by epigenetic regulation of targets involved in root system architecture

New Phytologist, EarlyView.
Summary Developmental processes are regulated at multiple levels, including the epigenetic level. Among the epigenetic factors, histone H3 lysine 4 (H3K4) methyltransferases contribute to active transcription of target genes, and here, we explored how the H3K4 methyltransferase ARABIDOPSIS HOMOLOG OF TRITHORAX1 (ATX1) affects Arabidopsis thaliana ...
Selene Napsucialy‐Mendivil, Héctor H. Torres‐Martínez, Gustavo Rodríguez‐Alonso, Diana Marcela Rivera‐Toro, Raúl Alvarez‐Venegas, Marco Adán Júarez‐Verdayes, Svetlana Shishkova, Joseph G. Dubrovsky   +7 more
wiley   +1 more source

Genetic Characterization and Role in Virulence of the Ribonucleotide Reductases of Streptococcus sanguinis [PDF]

, 2013
Streptococcus sanguinis is a cause of infective endocarditis and has been shown to require a manganese transporter called SsaB for virulence and O2 tolerance. Like certain other pathogens, S.
Crump, Katie E., Ge, Xiuchun, Kitten, Todd, Makhlynets, Olga, Rhodes, DeLacy V., Snyder, Melanie, Stubbe, JoAnne, Xu, Ping   +7 more
core   +2 more sources

The Hsp70 co-chaperone Ydj1/HDJ2 regulates ribonucleotide reductase activity.

PLoS Genetics, 2018
Hsp70 is a well-conserved molecular chaperone involved in the folding, stabilization, and eventual degradation of many "client" proteins. Hsp70 is regulated by a suite of co-chaperone molecules that assist in Hsp70-client interaction and stimulate the ...
Isaac T Sluder, Nitika, Laura E Knighton, Andrew W Truman   +3 more
doaj   +1 more source

Biofilm modifies expression of ribonucleotide reductase genes in Escherichia coli. [PDF]

PLoS ONE, 2012
Ribonucleotide reductase (RNR) is an essential enzyme for all living organisms since is the responsible for the last step in the synthesis of the four deoxyribonucleotides (dNTPs) necessary for DNA replication and repair.
Maria del Mar Cendra, Antonio Juárez, Eduard Torrents   +2 more
doaj   +1 more source

Inhibition of Bacterial Ribonucleotide Reductases by Arabinonucleotides [PDF]

European Journal of Biochemistry, 1978
Ribonucleoside diphosphate reductase of Escherichia coli and ribonucleoside triphosphate reductase of Lactobacillus leichmannii are inhibited by the 5′-diphosphates and triphosphates of arabinosyladenine and arabinosylcytosine in vitro. Competitive inhibition with respect to substrate nucleotides occurs in the case of aCTP (Lactobacillus enzyme) and ...
Hartmut Follmann, Walter Ludwig
openaire   +3 more sources

Management of T‐cell malignancies: Bench‐to‐bedside targeting of epigenetic biology

CA: A Cancer Journal for Clinicians, Volume 75, Issue 4, Page 282-307, July/August 2025.
Abstract The peripheral T‐cell lymphomas (PTCL) are the only disease for which four histone deacetylase (HDAC) inhibitors have been approved globally as single agents. Although it is not clear why the PTCL exhibit such a vulnerability to these drugs, understanding the biological basis for this activity is essential.
Ariana Sabzevari, Johnson Ung, Jeffrey W. Craig, Kallesh D. Jayappa, Ipsita Pal, David J. Feith, Thomas P. Loughran Jr, Owen A. O’Connor   +7 more
wiley   +1 more source

Quantification and expert evaluation of evidence for chemopredictive biomarkers to personalize cancer treatment. [PDF]

, 2017
Predictive biomarkers have the potential to facilitate cancer precision medicine by guiding the optimal choice of therapies for patients. However, clinicians are faced with an enormous volume of often-contradictory evidence regarding the therapeutic ...
Beckman, Robert A., Boca, Simina M., Brody, Jonathan R., Madhavan, Subha, Marshall, John L., Pishvaian, Michael J., Rao, Shruti, Riazi, Shahla, Yabar, Cinthya S.   +8 more
core   +1 more source

The Role of Iron Chelation Therapy in Colorectal Cancer: A Systematic Review on Its Mechanisms and Therapeutic Potential

Cancer Medicine, Volume 14, Issue 13, July 2025.
Iron chelation is a promising yet underexplored strategy for colorectal cancer (CRC) treatment. Iron chelators have a dual role in inhibiting and potentially promoting cancer progression. Iron chelation affects key CRC pathways, including histone methylation, NDRG1 upregulation, Wnt/β‐catenin, and p53 modulation.
Gihani Vidanapathirana, Md Sajedul Islam, Sujani Gamage, Alfred K. Lam, Vinod Gopalan   +4 more
wiley   +1 more source

Thioredoxin and glutaredoxin-mediated redox regulation of ribonucleotide reductase.

World Journal of Biological Chemsitry, 2014
Ribonucleotide reductase (RNR), the rate-limiting enzyme in DNA synthesis, catalyzes reduction of the different ribonucleotides to their corresponding deoxyribonucleotides.
R. Sengupta, A. Holmgren
semanticscholar   +1 more source

Polymorphic Distribution of Human Homeostatic Iron Regulator Gene H63D rs1799945 and Clinico‐Hematological Parameters of Sickle Cell Anemia Patients: A Case‐Control Study in Northern Ghana

Health Science Reports, Volume 8, Issue 7, July 2025.
ABSTRACT Background and Aim The study assessed the polymorphic distribution of H63D rs1799945 of HFE gene and clinico‐hematological parameters of SCA patients. Methods Sixty sickle cell anemia (SCA) patients and 30 healthy controls without sickle cell disease between the ages of 2–38 years were selected for this case‐control study from March to July ...
Samuel Kwasi Appiah, Charles Nkansah, Samira Daud, Gabriel Abbam, Felix Osei‐Boakye, Larry Adom, Rekhiatu Oboirien Abdul Rauf, Godfred Takyi Addae, Lydia Sarpong, Godfred Amoah Appiah, Charles Agnaatah Derigubah, Jennifer Obeng Mensah, Onwuka Chima Kalu, Victor U. Usanga, Boniface Nwofoke Ukwah, Ejike Felix Chukwurah   +15 more
wiley   +1 more source