Results 111 to 120 of about 209,934 (286)

Control of metallation and active cofactor assembly in the class Ia and Ib ribonucleotide reductases: diiron or dimanganese? [PDF]

, 2011
Ribonucleotide reductases (RNRs) convert nucleotides to deoxynucleotides in all organisms. Activity of the class Ia and Ib RNRs requires a stable tyrosyl radical (Y•), which can be generated by the reaction of O[subscript 2] with a diferrous cluster on ...
Cotruvo, Joseph A., Stubbe, JoAnne
core   +1 more source

Phase Separation Regulates Metabolism, Mitochondria, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Mitochondrion‐related liquid–liquid phase separation. (1) Phase separation mediates the self‐assembly of mitochondrial nucleoids (mt‐nucleoids). (2) Phase segregation mediates the formation of mitochondrial RNA granules (MRGs). (3) Phase separation mediates the formation of mitochondrial degradosomes.
Chuan Gao, Peng Ding, Changqing Zhang, Junjie Gao   +3 more
wiley   +1 more source

Bcl2 induces DNA replication stress by inhibiting ribonucleotide reductase.

Cancer Research, 2014
DNA replication stress is an inefficient DNA synthesis process that leads replication forks to progress slowly or stall. Two main factors that cause replication stress are alterations in pools of deoxyribonucleotide (dNTP) precursors required for DNA ...
Maohua Xie, Y. Yen, T. Owonikoko, S. Ramalingam, F. Khuri, W. Curran, P. Doetsch, Xingming Deng   +7 more
semanticscholar   +1 more source

Aging‐Associated Vacuolation of Multi‐Ciliated Cells in the Distal Mouse Oviduct Reflects Unique Cell Identity and Luminal Microenvironment

Aging Cell, Volume 24, Issue 7, July 2025.
Multi‐ciliated cells in the infundibulum and ampulla (INF/AMP) epithelium are vacuolated in aging. Unique cellular susceptibility of the INF/AMP epithelial population and aging‐associated decline in ovarian artery circulation, which supports the ovary and INF/AMP, contribute to this region‐specific vacuolation phenotype, as a consequence of a mildly ...
Keerthana Harwalkar, Nobuko Yamanaka, Alain S. Pacis, Selina Zhao, Katie Teng, Warwick Pitman, Mitaali Taskar, Vera Lynn, Alex Frances Thornton, Matthew J. Ford, Yojiro Yamanaka   +10 more
wiley   +1 more source

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, Volume 26, Issue 11, June 3, 2025.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source

Deoxynucleoside salvage in fission yeast allows rescue of ribonucleotide reductase deficiency but not Spd1-Mediated inhibition of replication [PDF]

, 2017
In fission yeast, the small, intrinsically disordered protein S-phase delaying protein 1 (Spd1) blocks DNA replication and causes checkpoint activation at least in part, by inhibiting the enzyme ribonucleotide reductase, which is responsible for the ...
Antony Carr, Birthe Kragelund, Christian Holmberg, Edgar Hartsuiker, Gordon, Irina Marinova, Katrine Løvschal, Marie-Fabrice Gasasira, Moreno, Olaf Nielsen, Oliver Fleck, Ulrik Fahnøe, Woollard, Yoshida   +13 more
core   +3 more sources

Ribonucleotide Reductase in Developing Brain

Journal of Biological Chemistry, 1972
Abstract Ribonucleotide reductase activity has been measured as a function of gestational age in the brains of the mouse, rat, chicken, and human, and in the cerebellum of rats during the first 2 weeks after birth. Some of the properties of the cerebral enzyme have been determined. The pattern of activity found in the developing brain is related to the
openaire   +3 more sources

Acute neuroinflammation induces AIS structural plasticity in a NOX2-dependent manner [PDF]

, 2017
Background Chronic microglia-mediated inflammation and oxidative stress are well-characterized underlying factors in neurodegenerative disease, whereby reactive inflammatory microglia enhance ROS production and impact neuronal integrity. Recently, it has
Benusa, S. D., DeVries, G. H., Dupree, J. L., George, N. M., Sword, B. A.   +4 more
core   +1 more source

Unveiling the Connection: Viral Infections and Genes in dNTP Metabolism

Viruses
Deoxynucleoside triphosphates (dNTPs) are crucial for the replication and maintenance of genomic information within cells. The balance of the dNTP pool involves several cellular enzymes, including dihydrofolate reductase (DHFR), ribonucleotide reductase (
Shih-Yen Lo, Meng-Jiun Lai, Chee-Hing Yang, Hui-Chun Li   +3 more
doaj   +1 more source

α-N-heterocyclic thiosemicarbazone derivatives as potential antitumor agents: A structure-activity relationships approach [PDF]

, 2009
α-N-Heterocyclic thiosemicarbazones, (N)-TSCs, are potent inhibitors of ribonucleotide reductase (RR). This enzyme plays a critical role in DNA synthesis and repair, and is a well-recognized target for cancer chemotherapeutic agents.
Matesanz, Ana I., Souza, Pilar
core   +2 more sources