Results 121 to 130 of about 209,934 (286)
The Manganese-containing Ribonucleotide Reductase of Corynebacterium ammoniagenes is a Class Ib Enzyme [PDF]
, 1998 Ribonucleotide reductases (RNRs) are key enzymes in living cells that provide the precursors of DNA synthesis. The three characterized classes of RNRs differ by their metal cofactor and their stable organic radical.
Barbé García, Jordi +8 more
core +2 more sources
Comparison of the Ribonucleotide with the Canavanine Reductase System
Experimental Biology and Medicine, 1974 SummaryReduced lipoate and dithiothreitol act as hydrogen donors in the canavanine and ribonucleotide reductase systems. Other thiol derivatives such as cysteine, 2,3-dimercapto-1-propanol (BAL), and glutathione cannot substitute effectively for the lipoate or dithiothreitol. Fe2+ acts as a cofactor for both systems.
Arnold L. Schultz +2 more
openaire +3 more sources
Unlocking the potential of RNA interference as a therapeutic tool [PDF]
, 2009 The existence of an intrinsic biochemical pathway enabling specified regulation of gene expression was unheard of until the final years of the last decade.
Ayers, Duncan, Day, Philip JR
core
Complete genome sequence and taxonomic position of anguillid herpesvirus 1 [PDF]
, 2010 Eel herpesvirus or anguillid herpesvirus 1 (AngHV1) frequently causes disease in freshwater eels. The complete genome sequence of AngHV1 and its taxonomic position within the family Alloherpesviridae were determined. Shotgun sequencing revealed a 249 kbp
Abma-Henkens, M.H.C. +8 more
core +3 more sources
Journal of Translational Medicine, 2012 Background The potent ribonucleotide reductase (RNR) inhibitor 3-aminopyridine-2-carboxyaldehyde-thiosemicarbazone (3-AP) was tested as a chemosensitizer for restored cisplatin-mediated cytotoxicity in platinum-resistant ovarian cancer.
Kunos Charles +6 more
doaj +1 more source
Interleukin -2 ( Il-2 ) and Gamma Interferon ( Ifn ? ) of Lymphocyte Culture Supernatant in Iron Deficiency Anemia Patients with Infection [PDF]
, 2010 Iron is an essential nutrient for every living cells because of it role as molecule fortransport of oxygen, as well as DNA synthesis through synthesis of ribonucleotidereductase.
Bakta, I. M. (I) +3 more
core
A bioinformatic analysis of ribonucleotide reductase genes in phage genomes and metagenomes
BMC Evolutionary Biology, 2013 Ribonucleotide reductase (RNR), the enzyme responsible for the formation of deoxyribonucleotides from ribonucleotides, is found in all domains of life and many viral genomes.
Bhakti Dwivedi +4 more
semanticscholar +1 more source
PLoS ONE, 2014 Ribonucleotide reductase M1 (RRM1) is required for mammalian deoxyribonucleotide (dNTP) metabolism. It is the primary target of the antimetabolite drug gemcitabine, which is among the most efficacious and most widely used cancer therapeutics. Gemcitabine
Yingtao Zhang +3 more
doaj +1 more source
Distribution of ribonucleotide reductase in the genus Synechococcus [PDF]
, 1978 Florence K. Gleason
openalex +1 more source
Cancer Research, 2013 Ribonucleotide reductase (RNR) is an attractive target for anticancer agents given its central function in DNA synthesis, growth, metastasis, and drug resistance of cancer cells.
Bingsen Zhou +11 more
semanticscholar +1 more source