Results 131 to 140 of about 209,934 (286)

Salvage enzymes in nucleotide biosynthesis [PDF]

, 2007
Balanced pools of deoxyribonucleoside triphosphates (dNTPs), the building blocks of DNA, and ribonucleoside triphosphates (NTPs), the precursors of RNA, are crucial for a controlled cell proliferation.
Kosinska, Urszula
core  

Ribonucleoside 5′‐thiodiphosphates as Substrates for Escherichia coli Ribonucleotide Reductase [PDF]

, 1974
Ulrika von Döbeln, Fritz Eckstein
openalex   +1 more source

A novel RRM2B mutation associated with mitochondrial DNA depletion syndrome

Molecular Genetics and Metabolism Reports, 2022
Mitochondrial DNA (mtDNA) depletion syndromes are disorders characterized by infantile-onset, severe progression, and the drastic loss of mtDNA content in affected tissues.
Monica Fumagalli, Dario Ronchi, Maria Francesca Bedeschi, Arianna Manini, Gloria Cristofori, Fabio Mosca, Robertino Dilena, Monica Sciacco, Simona Zanotti, Daniela Piga, Gianluigi Ardissino, Fabio Triulzi, Stefania Corti, Giacomo P. Comi, Leonardo Salviati   +14 more
doaj  

Identification of the stable free radical tyrosine residue in ribonucleotide reductase. [PDF]

, 1986
Å. Larsson, Britt‐Marie Sjöberg
openalex   +1 more source

Experimental, insilico, DFT studies of novel compound 2-{2-[(3,4-dimethoxyphenyl)methylidene]hydrazinecarbonothioyl}-N-methyl-N- phenylhydrazine-1-carbothioamide

Results in Chemistry, 2022
In the current investigation, we have obtained single crystals 2-{2-[(3,4-dimethoxyphenyl)methylidene]hydrazinecarbonothioyl}-N-methyl-N-phenylhydrazine-1-carbothioamide (H2L) by refluxing 3,4 dimethoxybenzaldehyde and N(4)- methyl-N(4)-phenyl ...
K.G. Sangeetha, K.K. Aravindakshan
doaj  

Inhibition of leukemic HL60 cell growth by transferrin-gallium: effects on ribonucleotide reductase and demonstration of drug synergy with hydroxyurea [see comments] [PDF]

, 1988
CR Chitambar, WG Matthaeus, WE Antholine, K Graff, WJ O'Brien   +4 more
openalex   +1 more source

Orotic Aciduria [PDF]

, 2018
Orotic acid is an intermediate found in the pathway for pyrimidine synthesis. The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) catalyzes the production of orotic acid by the conversion of the compound dihydroorotate to orotic acid.
Fonteh, Aliah L
core   +1 more source

Structure of a ribonucleotide reductase R2 protein radical. [PDF]

Science, 2023
Lebrette H, Srinivas V, John J, Aurelius O, Kumar R, Lundin D, Brewster AS, Bhowmick A, Sirohiwal A, Kim IS, Gul S, Pham C, Sutherlin KD, Simon P, Butryn A, Aller P, Orville AM, Fuller FD, Alonso-Mori R, Batyuk A, Sauter NK, Yachandra VK, Yano J, Kaila VRI, Sjöberg BM, Kern J, Roos K, Högbom M.   +27 more
europepmc   +1 more source

Radicals and the Birth and Death of DNA

CHIMIA, 2001
Radicals have important functions in the enzymatic synthesis of deoxyribonucleotides and their destruction by antibiotics. The chemical basis for these reactions is that radicals dramatically speed up ionic reactions.
Bernd Giese
doaj   +2 more sources

Structural insights into the initiation of free radical formation in the Class Ib ribonucleotide reductases in Mycobacteria

Current Research in Structural Biology
Class I ribonucleotide reductases consisting of α and β subunits convert ribonucleoside diphosphates to deoxyribonucleoside diphosphates involving an intricate free radical mechanism.
Lumbini R. Yadav, Vasudha Sharma, Maheswaran Shanmugam, Shekhar C. Mande   +3 more
doaj