Results 11 to 20 of about 196,005 (260)
Hydroxyurea-Mediated Cytotoxicity Without Inhibition of Ribonucleotide Reductase
Cell Reports, 2016 In many organisms, hydroxyurea (HU) inhibits class I ribonucleotide reductase, leading to lowered cellular pools of deoxyribonucleoside triphosphates. The reduced levels for DNA precursors is believed to cause replication fork stalling. Upon treatment of
Li Phing Liew +6 more
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The Hsp70 co-chaperone Ydj1/HDJ2 regulates ribonucleotide reductase activity.
PLoS Genetics, 2018 Hsp70 is a well-conserved molecular chaperone involved in the folding, stabilization, and eventual degradation of many "client" proteins. Hsp70 is regulated by a suite of co-chaperone molecules that assist in Hsp70-client interaction and stimulate the ...
Isaac T Sluder +3 more
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Frontiers in Microbiology, 2018 Pseudomonas aeruginosa is a major pathogenic bacterium in chronic infections and is a model organism for studying biofilms. P. aeruginosa is considered an aerobic bacterium, but in the presence of nitrate, it also grows in anaerobic conditions.
Anna Crespo +2 more
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mBio, 2017 Understanding how bacteria coordinate growth with cell cycle events to maintain cell size homeostasis remains a grand challenge in biology. The period of chromosome replication (C period) is a key stage in the bacterial cell cycle. However, the mechanism
Manlu Zhu +6 more
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Scientific Reports, 2018 The tumor suppressor p53 is commonly inactivated in human tumors, allowing evasion of p53-dependent apoptosis and tumor progression. The small molecule APR-246 (PRIMA-1Met) can reactive mutant p53 in tumor cells and trigger cell death by apoptosis.
Lena Haffo +7 more
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eLife, 2016 Ribonucleotide reductase (RNR) converts ribonucleotides to deoxyribonucleotides, a reaction that is essential for DNA biosynthesis and repair. This enzyme is responsible for reducing all four ribonucleotide substrates, with specificity regulated by the ...
Christina M Zimanyi +4 more
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Ribonucleotide reductase small subunit M2 promotes the proliferation of esophageal squamous cell carcinoma cells via HuR-mediated mRNA stabilization [PDF]
Acta Pharmaceutica Sinica BEsophageal squamous cell carcinoma (ESCC), a malignancy of the digestive system, is highly prevalent and the primary cause of cancer-related deaths worldwide due to the lack of early diagnostic biomarkers and effective therapeutic targets.
Jing Zhang +13 more
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Reversible, Long-Range Radical Transfer in E. coli Class Ia Ribonucleotide Reductase
Accounts of Chemical Research, 2013 Ellen C. Minnihan +2 more
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Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition
bioRxiv, 2021 Viruses use a plethora of mechanisms to evade immune responses. A new example is neutralization of the nuclear DNA cytosine deaminase APOBEC3B by the Epstein-Barr virus (EBV) ribonucleotide reductase subunit BORF2.
N. Shaban +8 more
semanticscholar +1 more source
RIBONUCLEOTIDE REDUCTASES [PDF]
Annual Review of Biochemistry, 1998 Ribonucleotide reductases provide the building blocks for DNA replication in all living cells. Three different classes of enzymes use protein free radicals to activate the substrate. Aerobic class I enzymes generate a tyrosyl radical with an iron-oxygen center and dioxygen, class II enzymes employ adenosylcobalamin, and the anaerobic class III enzymes
A, Jordan, P, Reichard
openaire +2 more sources