Results 11 to 20 of about 209,934 (286)

Manipulating the Bacterial Cell Cycle and Cell Size by Titrating the Expression of Ribonucleotide Reductase

mBio, 2017
Understanding how bacteria coordinate growth with cell cycle events to maintain cell size homeostasis remains a grand challenge in biology. The period of chromosome replication (C period) is a key stage in the bacterial cell cycle. However, the mechanism
Manlu Zhu, Xiongfeng Dai, Weilun Guo, Zengxiang Ge, Mingxuan Yang, Haikuan Wang, Yi-Ping Wang   +6 more
doaj   +2 more sources

Ribonucleotide reductase, a novel drug target for gonorrhea [PDF]

eLife, 2022
Antibiotic-resistant Neisseria gonorrhoeae (Ng) are an emerging public health threat due to increasing numbers of multidrug resistant (MDR) organisms. We identified two novel orally active inhibitors, PTC-847 and PTC-672, that exhibit a narrow spectrum ...
Jana Narasimhan, Suzanne Letinski, Stephen P Jung, Aleksey Gerasyuto, Jiashi Wang, Michael Arnold, Guangming Chen, Jean Hedrick, Melissa Dumble, Kanchana Ravichandran, Talya Levitz, Chang Cui, Catherine L Drennan, JoAnne Stubbe, Gary Karp, Arthur Branstrom   +15 more
doaj   +2 more sources

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

Scientific Reports, 2018
The tumor suppressor p53 is commonly inactivated in human tumors, allowing evasion of p53-dependent apoptosis and tumor progression. The small molecule APR-246 (PRIMA-1Met) can reactive mutant p53 in tumor cells and trigger cell death by apoptosis.
Lena Haffo, Jun Lu, Vladimir J. N. Bykov, Sebastin S. Martin, Xiaoyuan Ren, Lucia Coppo, Klas G. Wiman, Arne Holmgren   +7 more
doaj   +2 more sources

Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli

eLife, 2016
Ribonucleotide reductase (RNR) converts ribonucleotides to deoxyribonucleotides, a reaction that is essential for DNA biosynthesis and repair. This enzyme is responsible for reducing all four ribonucleotide substrates, with specificity regulated by the ...
Christina M Zimanyi, Percival Yang-Ting Chen, Gyunghoon Kang, Michael A Funk, Catherine L Drennan   +4 more
doaj   +2 more sources

Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer [PDF]

Biochemistry, 2015
Ribonucleotide reductases (RNRs) are responsible for all de novo biosynthesis of DNA precursors in nature by catalyzing the conversion of ribonucleotides to deoxyribonucleotides. Because of its essential role in cell division, human RNR is a target for a
N. Ando, Haoran Li, E. Brignole, S. Thompson, Martin I McLaughlin, J. Page, F. Asturias, J. Stubbe, C. Drennan   +8 more
semanticscholar   +5 more sources

A Ferredoxin Disulfide Reductase Delivers Electrons to the Methanosarcina barkeri Class III Ribonucleotide Reductase [PDF]

Biochemistry, 2015
Two subtypes of class III anaerobic ribonucleotide reductases (RNRs) studied so far couple the reduction of ribonucleotides to the oxidation of formate, or the oxidation of NADPH via thioredoxin and thioredoxin reductase.
Yifeng Wei, Bin Li, D. Prakash, J. Ferry, S. Elliott, J. Stubbe   +5 more
semanticscholar   +3 more sources

Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer. [PDF]

Genes Dis, 2022
Zuo Z, Zhou Z, Chang Y, Liu Y, Shen Y, Li Q, Zhang L.   +6 more
europepmc   +2 more sources

Reversible, long-range radical transfer in E. coli class Ia ribonucleotide reductase. [PDF]

Accounts of Chemical Research, 2013
Ribonucleotide reductases (RNRs) catalyze the conversionof nucleotides to 2'-deoxynucleotides and are classified on the basis of the metallo-cofactor used to conduct this chemistry.
E. Minnihan, D. Nocera, J. Stubbe
semanticscholar   +3 more sources

The periodic table of ribonucleotide reductases [PDF]

Journal of Biological Chemistry, 2021
In most organisms, transition metal ions are necessary cofactors of ribonucleotide reductase (RNR), the enzyme responsible for biosynthesis of the 2'-deoxynucleotide building blocks of DNA. The metal ion generates an oxidant for an active site cysteine (Cys), yielding a thiyl radical that is necessary for initiation of catalysis in all RNRs.
Terry B. Ruskoski, Amie K. Boal
openaire   +3 more sources

Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition

bioRxiv, 2021
Viruses use a plethora of mechanisms to evade immune responses. A new example is neutralization of the nuclear DNA cytosine deaminase APOBEC3B by the Epstein-Barr virus (EBV) ribonucleotide reductase subunit BORF2.
N. Shaban, Rui Yan, K. Shi, Sofia N. Moraes, A. Cheng, M. Carpenter, J. McLellan, Zhiheng Yu, R. Harris   +8 more
semanticscholar   +1 more source