Results 221 to 230 of about 196,005 (260)
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Imaging active ribonucleotide reductase

C&EN Global Enterprise, 2020
Ribonucleotide reductases (RNRs) play a crucial role in cells as the only source of the building blocks needed for DNA replication and repair.
openaire   +1 more source

Ribonucleotide Reductase and Deoxyribonucleotide Pools

1985
Ribonucleotide reductase plays a crucial role in the maintenance of dNTP pools. A molecular model for the allosteric regulation of the enzyme is substantiated by the effects of nucleosides or inhibitors on pool sizes in intact cells as well as by manifestations of mutations of the reductase and other enzymes involved in deoxynucleoside metabolism ...
openaire   +2 more sources

Clinical pharmacology and clinical trials of ribonucleotide reductase inhibitors: is it a viable cancer therapy?

Journal of Cancer Research and Clinical Oncology, 2017
Mukundan Baskar Mannargudi, S. Deb
semanticscholar   +1 more source

Human ribonucleotide reductase

Biochemical Pharmacology, 1991
Joan A. Harrington, Thomas Spector
openaire   +1 more source

Inhibition of hepatitis B virus replication by targeting ribonucleotide reductase M2 protein.

Biochemical Pharmacology, 2016
Xia Liu   +13 more
semanticscholar   +1 more source

Chiral synthesis of LSD1 inhibitor GSK2879552 enabled by directed evolution of an imine reductase

Nature Catalysis, 2019
Chris Macdermaid   +2 more
exaly  

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