Results 271 to 280 of about 209,934 (286)
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Structure of ribonucleotide reductase protein R1
Nature, 1994Ribonucleotide reductase is the only enzyme that catalyses de novo formation of deoxyribonucleotides and is thus a key enzyme in DNA synthesis. The radical-based reaction involves five cysteins. Two redox-active cysteines are located at adjacent antiparallel strands in a new type of ten-stranded alpha/beta-barrel, and two others at the carboxyl end in ...
Ulla Uhlin, Hans Eklund
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Ribonucleotide Reductase and Deoxyribonucleotide Pools
1985Ribonucleotide reductase plays a crucial role in the maintenance of dNTP pools. A molecular model for the allosteric regulation of the enzyme is substantiated by the effects of nucleosides or inhibitors on pool sizes in intact cells as well as by manifestations of mutations of the reductase and other enzymes involved in deoxynucleoside metabolism ...
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Ribonucleotide reductase from saccharomyces cerevisiae
Biochemical and Biophysical Research Communications, 1970Partially purified ribonucleotide reductase from Saccharomyces cerevisiae was unstable in solution; however, enzyme activity could be maintained by quick-freezing and storage at low temperatures. The reduction of CDP was stimulated by ATPMg++, and maximal activity was obtained with E.
V.A. Bauer +2 more
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Ribonucleotide reductase of herpesviruses [PDF]
Reviews in Medical Virology, 1994 J. B. Clements +2 more
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Imaging active ribonucleotide reductase
C&EN Global Enterprise, 2020Ribonucleotide reductases (RNRs) play a crucial role in cells as the only source of the building blocks needed for DNA replication and repair.
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Hydroxamates as Ribonucleotide Reductase Inhibitors
2013This chapter presents the progress in the design and discovery of hydroxamic acids acting as ribonucleotide reductase (RR) inhibitors. The RR inhibitors act as anticancer agents. The initial sections present a background about hydroxamic acids, role of RR inhibitors as anticancer agents, and information on three-dimensional structure of RR.
Arijit Basu, Barij Nayan Sinha
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Interaction of ribonucleotide reductase with ribonucleotide analogs
Biochemistry, 1971Hogenkamp Hp, Follmann H
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Ribonucleotide reductases: Substrate specificity by allostery
Biochemical and Biophysical Research Communications, 2010Ribonucleotide reductases catalyze in all living organisms the production of deoxynucleotides from ribonucleotides. A single enzyme provides a balanced supply of the four dNTPs required for DNA replication. Three different but related classes of enzymes are known.
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Is the mammalian ribonucleotide reductase really like Escherichia coli's ribonucleotide reductase?
Pharmacology & Therapeutics, 1985Whitfield, James, Youdale, T.
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