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RIBONUCLEOTIDE REDUCTASES [PDF]

Annual Review of Biochemistry, 1998
Ribonucleotide reductases provide the building blocks for DNA replication in all living cells. Three different classes of enzymes use protein free radicals to activate the substrate. Aerobic class I enzymes generate a tyrosyl radical with an iron-oxygen center and dioxygen, class II enzymes employ adenosylcobalamin, and the anaerobic class III enzymes
A, Jordan, P, Reichard
openaire   +2 more sources

Author Correction: Characterization of a second class Ie ribonucleotide reductase [PDF]

Communications Biology
Juliane John, Daniel Lundin, Rui M. Branca, Rohit Kumar, Vivek Srinivas, Hugo Lebrette, Martin Högbom   +6 more
doaj   +2 more sources

TAS1553, a small molecule subunit interaction inhibitor of ribonucleotide reductase, exhibits antitumor activity by causing DNA replication stress

Communications Biology, 2022
A small-molecule protein-protein interaction inhibitor of ribonucleotide reductase subunit, TAS1553, is shown to inhibit growth of both hematological and solid cancer xenograft tumors following oral administration in mice.
Hiroyuki Ueno, Takuya Hoshino, Wakako Yano, Sayaka Tsukioka, Takamasa Suzuki, Shoki Hara, Yoshio Ogino, Khoon Tee Chong, Tatsuya Suzuki, Shingo Tsuji, Hikaru Itadani, Ikuo Yamamiya, Yoshihiro Otsu, Satoshi Ito, Toshiya Yonekura, Miki Terasaka, Nozomu Tanaka, Seiji Miyahara   +17 more
doaj   +1 more source

Structure of a trapped radical transfer pathway within a ribonucleotide reductase holocomplex

Science, 2020
Caught in the act Proton-coupled electron transfer (PCET) is an important process for moving electrons through proteins and requires precise positioning of suitable proton and electron carriers. Kang et al. determined a cryo–electron microscopy structure
Gyunghoon Kang, Alexander T. Taguchi, J. Stubbe, C. Drennan   +3 more
semanticscholar   +1 more source

Analysis of the ex vivo and in vivo antiretroviral activity of gemcitabine. [PDF]

PLoS ONE, 2011
Replication of retroviral and host genomes requires ribonucleotide reductase to convert rNTPs to dNTPs, which are then used as substrates for DNA synthesis.
Christine L Clouser, Colleen M Holtz, Mary Mullett, Duane L Crankshaw, Jacquie E Briggs, Jay Chauhan, Ilze Matise VanHoutan, Steven E Patterson, Louis M Mansky   +8 more
doaj   +1 more source

Dehydration of Ribonucleotides Catalyzed by Ribonucleotide Reductase: The Role of the Enzyme [PDF]

Biophysical Journal, 2006
This article focuses on the second step of the catalytic mechanism for the reduction of ribonucleotides catalyzed by the enzyme Ribonucleotide Reductase (RNR). This step corresponds to the protonation/elimination of the substrate's C-2' hydroxyl group.
Leif A. Eriksson, Maria J. Ramos, Pedro A. Fernandes, Nuno M. F. S. A. Cerqueira   +3 more
openaire   +3 more sources

Ribonucleotide Reductase

Allosteric Enzymes, 2020
Ribonucleotide Reductase is a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. It consists of two subunits, M1 Chain and M2 Chain. Complex allosteric
S. Eriksson, B. Sjöberg
semanticscholar   +1 more source

Thioredoxin reductase from Bacillus cereus exhibits distinct reduction and NADPH‐binding properties

FEBS Open Bio, 2021
Low‐molecular‐weight (low Mr) thioredoxin reductases (TrxRs) are homodimeric NADPH‐dependent dithiol flavoenzymes that reduce thioredoxins (Trxs) or Trx‐like proteins involved in the activation networks of enzymes, such as the bacterial class Ib ...
Marita Shoor, Ingvild Gudim, Hans‐Petter Hersleth, Marta Hammerstad   +3 more
doaj   +1 more source

Hepatitis C Virus Down-Regulates the Expression of Ribonucleotide Reductases to Promote Its Replication

Pathogens, 2023
Ribonucleotide reductases (RRs or RNRs) catalyze the reduction of the OH group on the 2nd carbon of ribose, reducing four ribonucleotides (NTPs) to the corresponding deoxyribonucleotides (dNTPs) to promote DNA synthesis.
Chee-Hing Yang, Cheng-Hao Wu, Shih-Yen Lo, Ahai-Chang Lua, Yu-Ru Chan, Hui-Chun Li   +5 more
doaj   +1 more source

Spectroscopic and theoretical approaches for studying radical reactions in class I ribonucleotide reductase [PDF]

, 2005
Ribonucleotide reductases (RNRs) catalyze the production of deoxyribonucleotides, which are essential for DNA synthesis and repair in all organisms.
Atkin, Bennati, Bennati, Denysenkov, Ehrenberg, Kolberg, Ling, Mezyk, Milov, Oelgemöller, Schmittel, Sjöberg, Sjöberg, Steenken, Stubbe, Stubbe, Thelander, Thelander   +17 more
core   +2 more sources