Results 21 to 30 of about 196,005 (260)

Structure of a trapped radical transfer pathway within a ribonucleotide reductase holocomplex

Science, 2020
Caught in the act Proton-coupled electron transfer (PCET) is an important process for moving electrons through proteins and requires precise positioning of suitable proton and electron carriers. Kang et al. determined a cryo–electron microscopy structure
Gyunghoon Kang, Alexander T. Taguchi, J. Stubbe, C. Drennan   +3 more
semanticscholar   +1 more source

Analysis of the ex vivo and in vivo antiretroviral activity of gemcitabine. [PDF]

PLoS ONE, 2011
Replication of retroviral and host genomes requires ribonucleotide reductase to convert rNTPs to dNTPs, which are then used as substrates for DNA synthesis.
Christine L Clouser, Colleen M Holtz, Mary Mullett, Duane L Crankshaw, Jacquie E Briggs, Jay Chauhan, Ilze Matise VanHoutan, Steven E Patterson, Louis M Mansky   +8 more
doaj   +1 more source

Author Correction: Characterization of a second class Ie ribonucleotide reductase [PDF]

Communications Biology
Juliane John, Daniel Lundin, Rui M. Branca, Rohit Kumar, Vivek Srinivas, Hugo Lebrette, Martin Högbom   +6 more
doaj   +2 more sources

Hepatitis C Virus Down-Regulates the Expression of Ribonucleotide Reductases to Promote Its Replication

Pathogens, 2023
Ribonucleotide reductases (RRs or RNRs) catalyze the reduction of the OH group on the 2nd carbon of ribose, reducing four ribonucleotides (NTPs) to the corresponding deoxyribonucleotides (dNTPs) to promote DNA synthesis.
Chee-Hing Yang, Cheng-Hao Wu, Shih-Yen Lo, Ahai-Chang Lua, Yu-Ru Chan, Hui-Chun Li   +5 more
doaj   +1 more source

Ribonucleotide reductase inhibitors: a new look at an old target for radiosensitization

Frontiers in Oncology, 2012
Ribonucleotide reductase, the rate limiting enzyme in the synthesis and repair of DNA, has been studied as a target for inhibition in the treatment of cancer for many years.
Tobias eChapman, Timothy James Kinsella
doaj   +1 more source

Thioredoxin reductase from Bacillus cereus exhibits distinct reduction and NADPH‐binding properties

FEBS Open Bio, 2021
Low‐molecular‐weight (low Mr) thioredoxin reductases (TrxRs) are homodimeric NADPH‐dependent dithiol flavoenzymes that reduce thioredoxins (Trxs) or Trx‐like proteins involved in the activation networks of enzymes, such as the bacterial class Ib ...
Marita Shoor, Ingvild Gudim, Hans‐Petter Hersleth, Marta Hammerstad   +3 more
doaj   +1 more source

Gene Therapy Rescues Cardiac Dysfunction in Duchenne Muscular Dystrophy Mice by Elevating Cardiomyocyte Deoxy-Adenosine Triphosphate

JACC: Basic to Translational Science, 2019
Summary: Mutations in the gene encoding for dystrophin leads to structural and functional deterioration of cardiomyocytes and is a hallmark of cardiomyopathy in Duchenne muscular dystrophy (DMD) patients.
Stephen C. Kolwicz, Jr., PhD, John K. Hall, PhD, Farid Moussavi-Harami, MD, Xiolan Chen, PhD, Stephen D. Hauschka, PhD, Jeffrey S. Chamberlain, PhD, Michael Regnier, PhD, Guy L. Odom, PhD   +7 more
doaj   +1 more source

Structure-based in silico investigation of antagonists of human ribonucleotide reductase from Annona muricata

Informatics in Medicine Unlocked, 2023
Human ribonucleotide reductase (HRR) also known as ribonuceotide diphosphate reductase catalyzes the conversion of ribonucleotide to deoxyribonuceotides which is the rate limiting step in the synthesis of DNA, establishing the enzyme as a vital ...
Damilola A. Omoboyowa, Damilola S. Bodun, Jamiyu A. Saliu   +2 more
doaj   +1 more source

The Enhanced Tumor Specificity of TG6002, an Armed Oncolytic Vaccinia Virus Deleted in Two Genes Involved in Nucleotide Metabolism

Molecular Therapy: Oncolytics, 2019
Oncolytic vaccinia viruses are currently in clinical development. However, the safety and the tumor selectivity of these oncolytic viruses must be improved.
Johann Foloppe, Juliette Kempf, Nicolas Futin, Jacqueline Kintz, Pascale Cordier, Christelle Pichon, Annie Findeli, Fabien Vorburger, Eric Quemeneur, Philippe Erbs   +9 more
doaj   +1 more source

The Origin and Evolution of Ribonucleotide Reduction

Life, 2015
Ribonucleotide reduction is the only pathway for de novo synthesis of deoxyribonucleotides in extant organisms. This chemically demanding reaction, which proceeds via a carbon-centered free radical, is catalyzed by ribonucleotide reductase (RNR).
Daniel Lundin, Gustav Berggren, Derek T. Logan, Britt-Marie Sjöberg   +3 more
doaj   +1 more source