Results 31 to 40 of about 196,005 (260)
Nature Communications, 2022 Ribonucleotide reductase (RNR) is an essential enzyme that catalyzes the synthesis of DNA building blocks. Here, the authors present the cryo-EM structure and mechanism of action of NrdR, the RNR-specific repressor, that controls transcription of RNR ...
Inna Rozman Grinberg +8 more
doaj +1 more source
Journal of Virology, 2019 The APOBEC3 family of DNA cytosine deaminases constitutes a vital innate immune defense against a range of different viruses. A novel counterrestriction mechanism has recently been uncovered for the gammaherpesvirus EBV, in which a subunit of the viral ...
A. Cheng +11 more
semanticscholar +1 more source
Ribonucleotide reductase, a novel drug target for gonorrhea
eLife, 2022 Antibiotic-resistant Neisseria gonorrhoeae (Ng) are an emerging public health threat due to increasing numbers of multidrug resistant (MDR) organisms. We identified two novel orally active inhibitors, PTC-847 and PTC-672, that exhibit a narrow spectrum ...
Jana Narasimhan +15 more
doaj +1 more source
50 Years of Giese Reaction – a Personal View
Angewandte Chemie, EarlyView.The Giese‐Reaction celebrates its 50. Birthday, it is a cyclic radical chain reaction centered around C,C‐bond formation in a three component synthesis. This minireview speaks about the birth of the name‐reaction, explains how the complete understanding of its reaction mechanism stimulates new methods in organic synthesis, and why it can proceed in ...
Martin Spichty +4 more
wiley +2 more sources
eLife, 2023 Life requires ribonucleotide reduction for de novo synthesis of deoxyribonucleotides. As ribonucleotide reduction has on occasion been lost in parasites and endosymbionts, which are instead dependent on their host for deoxyribonucleotide synthesis, it ...
Samantha DM Arras +11 more
doaj +1 more source
Oncogene, 2018 DNA replication machinery is responsible for accurate and efficient duplication of the chromosome. Since inhibition of DNA replication can lead to replication fork stalling, resulting in DNA damage and apoptotic death, inhibitors of DNA replication are ...
Chi-Wei Chen +12 more
semanticscholar +1 more source
A New Type of YumC-Like Ferredoxin (Flavodoxin) Reductase Is Involved in Ribonucleotide Reduction
mBio, 2015 The trxB2 gene, which is annotated as a thioredoxin reductase, was found to be essential for growth of Lactococcus lactis in the presence of oxygen. The corresponding protein (TrxB2) showed a high similarity with Bacillus subtilis YumC (E value = 4.0E−88)
Jun Chen +3 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Conversion of ribonucleotides to the 2′-deoxyribonucleotides required for DNA biosynthesis is catalyzed by ribonucleotide reductases (RNRs) via a free-radical mechanism.
Elizabeth J. Blaesi +17 more
semanticscholar +1 more source
Structure-guided design of anti-cancer ribonucleotide reductase inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Ribonucleotide reductase (RR) catalyses the rate-limiting step of dNTP synthesis, establishing it as an important cancer target. While RR is traditionally inhibited by nucleoside-based antimetabolites, we recently discovered a naphthyl salicyl acyl ...
Tessianna A. Misko +6 more
doaj +1 more source
Cells, 2021 Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with a dismal prognosis. Here, we show how an inhibition of de novo dNTP synthesis by the ribonucleotide reductase (RNR) inhibitor hydroxyurea and an inhibition of epigenetic ...
Alexandra Nguyen +5 more
doaj +1 more source