Results 41 to 50 of about 196,005 (260)
Clinical application and drug resistance mechanism of gemcitabine
Frontiers in Cell and Developmental BiologyGemcitabine, as a nucleoside analog, exerts a broad-spectrum antitumor effect by interfering with DNA synthesis, but its clinical application is limited by drug resistance.
Xuanrui Zhang, Bing Qi, Jing Chen
doaj +1 more source
Advances of Ribonucleotide Reductase Inhibitors on Cancer
Zhongliu Fangzhi Yanjiu, 2019 Ribonucleotide reductase (RR) regulates dNTP production, catalyzing the reduction of ribonucleotide into deoxyribonucleotide diphosphate, which is essential in DNA synthesis and cell proliferation.
WANG An'ge, WU Zhe, WANG Li, QIU Yunqing
doaj +1 more source
γ-H2AX kinetics as a novel approach to high content screening for small molecule radiosensitizers. [PDF]
PLoS ONE, 2012 BACKGROUND:Persistence of γ-H2AX after ionizing radiation (IR) or drug therapy is a robust reporter of unrepaired DNA double strand breaks in treated cells.
Shibo Fu +11 more
doaj +1 more source
eLife, 2018 Ribonucleotide reductases (RNRs) convert ribonucleotides into deoxyribonucleotides, a reaction essential for DNA replication and repair. Human RNR requires two subunits for activity, the α subunit contains the active site, and the β subunit houses the ...
E. Brignole +8 more
semanticscholar +1 more source
P53 suppresses ribonucleotide reductase via inhibiting mTORC1
OncoTarget, 2017 Balanced deoxyribonucleotides pools are essential for cell survival and genome stability. Ribonucleotide reductase is the rate-limiting enzyme for the production of deoxyribonucleotides. We report here that p53 suppresses ribonucleotide reductase subunit
Zhengfu He +6 more
semanticscholar +1 more source
Radiopharmaceuticals for Persistent or Recurrent Uterine Cervix Cancer
Frontiers in Oncology, 2019 Uterine cervix cancers pose therapeutic challenges because of an overactive ribonucleotide reductase, which provides on-demand deoxyribonucleotides for DNA replication or for a DNA damage repair response.
Charles A. Kunos +3 more
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Animal Research and One Health, EarlyView.Woody breast compromises meat quality leading to reduced consumer appeal. Although its causes are unclear, improvements observed with certain dietary supplements suggest that gut health may influence woody breast development. Ribonucleotide reductase subunit RRM2 is vital for mitochondrial function and gastrointestinal integrity, and alteration in its ...
Majid Shakeri +8 more
wiley +1 more source
Advanced Science, 2021 Renal cell carcinoma (RCC) is a malignant tumor of the kidneys. Approximately 70% of RCC cases are clear cell renal cell carcinoma with von Hippel–Lindau (VHL) gene mutation and activation of the vascular endothelial growth factor (VEGF) pathway ...
Wei Xiong +5 more
doaj +1 more source
A novel RRM2B mutation associated with mitochondrial DNA depletion syndrome
Molecular Genetics and Metabolism Reports, 2022 Mitochondrial DNA (mtDNA) depletion syndromes are disorders characterized by infantile-onset, severe progression, and the drastic loss of mtDNA content in affected tissues.
Monica Fumagalli +14 more
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