Results 41 to 50 of about 209,934 (286)

Characterisation of an Escherichia coli line that completely lacks ribonucleotide reduction yields insights into the evolution of parasitism and endosymbiosis

eLife, 2023
Life requires ribonucleotide reduction for de novo synthesis of deoxyribonucleotides. As ribonucleotide reduction has on occasion been lost in parasites and endosymbionts, which are instead dependent on their host for deoxyribonucleotide synthesis, it ...
Samantha DM Arras, Nellie Sibaeva, Ryan J Catchpole, Nobuyuki Horinouchi, Dayong Si, Alannah M Rickerby, Kengo Deguchi, Makoto Hibi, Koichi Tanaka, Michiki Takeuchi, Jun Ogawa, Anthony M Poole   +11 more
doaj   +1 more source

Proteomes of Lactobacillus delbrueckii subsp. bulgaricus LBB.B5 Incubated in Milk at Optimal and Low Temperatures. [PDF]

, 2017
We identified the proteins synthesized by Lactobacillus delbrueckii subsp. bulgaricus strain LBB.B5 in laboratory culture medium (MRS) at 37°C and milk at 37 and 4°C.
Angel Angelov, Brett S. Phinney, Korneel Rabaey, Maria L. Marco, Michelle R. Salemi, Velitchka Gotcheva, Xiaochen Yin   +6 more
core   +2 more sources

Challenges of drug resistance in the management of pancreatic cancer [PDF]

, 2010
The current treatment of choice for metastatic pancreatic cancer involves single agent gemcitabine or combination of gemcitabine with capecitabine and erlotinib (tyrosine kinase inhibitor).
Akada, Allison, Almoguera, Andreetta, Arai, Arlt, Arteaga, Arumugam, Asano, Bachem, Baldwin, Banerjee, Bartsch, Bergers, Best, Bold, Bondar, Buck, Burris, Chakravarti, Chakravarti, Choi, Cunningham, Cunningham, Dancer, Dong, Duxbury, Duxbury, Duxbury, Duxbury, Engelman, Feldmann, Ferrero, Galmarini, Geyer, Giovannetti, Goan, Greer, Hagmann, Hahn, Henke, Hruban, Humeniuk, Ischenko, Ishikawa, Itoi, Jansen, Karapetis, Kindler, Kong, Koopman, Kulik, Lei, Lemoine, Liau, Liau, Longley, Mackey, Mackey, Mackey, Mahon, Mamaghani, Marechal, Marmor, Martin Clynes, Mata, Maxwell, Mendelsohn, Meropol, Miwa, Moertel, Molina-Arcas, Moore, Morgillo, Moriyama, Muerkoster, Muerkoster, Nakahira, Nakajima, Nakano, Naomi Walsh, Nishimura, Oguri, Okamoto, Okumura, Olive, O’Driscoll, Pao, Park, Park, Peters, Plunkett, Ray McDermott, Ritzel, Rizwan Sheikh, Robert O’Connor, Ruggeri, Safran, Saito, Sakamoto, Schuller, Sebastiani, Shah, Shi, Simon, Spratlin, Takao, Takebayashi, Treat, Tsukamoto, Tzeng, Vaishampayan, Van Cutsem, van der Wilt, Wang, Wang, Wang, Xiong, Yamasaki, Yokoi   +119 more
core   +1 more source

Cellular regulation of ribonucleotide reductase in eukaryotes.

Seminars in Cell & Developmental Biology, 2014
Synthesis of deoxynucleoside triphosphates (dNTPs) is essential for both DNA replication and repair and a key step in this process is catalyzed by ribonucleotide reductases (RNRs), which reduce ribonucleotides (rNDPs) to their deoxy forms. Tight regulation of RNR is crucial for maintaining the correct levels of all four dNTPs, which is important for ...
Estrella Guarino, Israel Salguero, S. Kearsey   +2 more
semanticscholar   +4 more sources

Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Conversion of ribonucleotides to the 2′-deoxyribonucleotides required for DNA biosynthesis is catalyzed by ribonucleotide reductases (RNRs) via a free-radical mechanism.
Elizabeth J. Blaesi, G. Palowitch, K. Hu, Amelia J. Kim, Hannah R. Rose, R. Alapati, Marshall G. Lougee, H. Kim, Alexander T. Taguchi, K. Tan, Tatiana N. Laremore, R. Griffin, C. Krebs, Megan L. Matthews, Alexey Silakov, J. Bollinger, Benjamin D. Allen, A. Boal   +17 more
semanticscholar   +1 more source

Effect of hydroxyurea on ribonucleotide reductase [PDF]

Biochemical and Biophysical Research Communications, 1968
Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/33096/1/0000482 ...
openaire   +4 more sources

Class 1 Histone Deacetylases and Ataxia-Telangiectasia Mutated Kinase Control the Survival of Murine Pancreatic Cancer Cells upon dNTP Depletion

Cells, 2021
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with a dismal prognosis. Here, we show how an inhibition of de novo dNTP synthesis by the ribonucleotide reductase (RNR) inhibitor hydroxyurea and an inhibition of epigenetic ...
Alexandra Nguyen, Melanie Dzulko, Janine Murr, Yun Yen, Günter Schneider, Oliver H. Krämer   +5 more
doaj   +1 more source

DHS (Trans-4,4’-Dihydroxystilbene) Suppresses DNA Replication and Tumor Growth by Inhibiting RRM2 (Ribonucleotide Reductase Regulatory Subunit M2)

Oncogene, 2018
DNA replication machinery is responsible for accurate and efficient duplication of the chromosome. Since inhibition of DNA replication can lead to replication fork stalling, resulting in DNA damage and apoptotic death, inhibitors of DNA replication are ...
Chi-Wei Chen, Yongming Li, Shuya Hu, W. Zhou, Yunxiao Meng, Zongzhu Li, Yi Zhang, Jing Sun, Zhou Bo, M. DePamphilis, Y. Yen, Zhiyong Han, Wenge Zhu   +12 more
semanticscholar   +1 more source

RRM2 (ribonucleotide reductase M2) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2014
Ribonucleotide reductase subunit M2 (RRM2) is located in chromosome-2 p25-p24, converts ribonucleotides to deoxynucleotides which is required for DNA polymerization and repair. It has been shown that RMM2 plays a key role in DNA synthesis, cell growth, and drug resistance of cancer cells. There is accumulating evidence that alteration in the expression
Afrasiabi, A, Fiuji, F, Mirhafez, R, Avan, A   +3 more
openaire   +4 more sources

The class III ribonucleotide reductase from Neisseria bacilliformis can utilize thioredoxin as a reductant [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2014
The class III anaerobic ribonucleotide reductases (RNRs) studied to date couple the reduction of ribonucleotides to deoxynucleotides with the oxidation of formate to CO[subscript 2]. Here we report the cloning and heterologous expression of the Neisseria
Yifeng Wei, M. Funk, L. Rosado, Jiyeon Baek, C. Drennan, J. Stubbe   +5 more
semanticscholar   +3 more sources