Structure-guided design of anti-cancer ribonucleotide reductase inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Ribonucleotide reductase (RR) catalyses the rate-limiting step of dNTP synthesis, establishing it as an important cancer target. While RR is traditionally inhibited by nucleoside-based antimetabolites, we recently discovered a naphthyl salicyl acyl ...
Tessianna A. Misko +6 more
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PtrA is required for coordinate regulation of gene expression during phosphate stress in a marine Synechococcus [PDF]
, 2010 Previous microarray analyses have shown a key role for the two-component system PhoBR (SYNW0947, SYNW0948) in the regulation of P transport and metabolism in the marine cyanobacterium Synechococcus sp. WH8102. However, there is some evidence that another
Johnson, Daniel +7 more
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Advances of Ribonucleotide Reductase Inhibitors on Cancer
Zhongliu Fangzhi Yanjiu, 2019 Ribonucleotide reductase (RR) regulates dNTP production, catalyzing the reduction of ribonucleotide into deoxyribonucleotide diphosphate, which is essential in DNA synthesis and cell proliferation.
WANG An'ge, WU Zhe, WANG Li, QIU Yunqing
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Journal of Clinical Pharmacy and Therapeutics, 2018 The prognostic value of ribonucleotide reductase M1 (RRM1) in patients with pancreatic cancer receiving gemcitabine chemotherapy has been evaluated in several studies. However, the conclusions remain controversial.
Quanli Han +4 more
semanticscholar +1 more source
The Tyrosyl Free Radical in Ribonucleotide Reductase [PDF]
Environmental Health Perspectives, 1985 The enzyme, ribonucleotide reductase, catalyses the formation of deoxyribonucleotides from ribonucleotides, a reaction essential for DNA synthesis in all living cells. The Escherichia coli ribonucleotide reductase, which is the prototype of all known eukaryotic and virus-coded enzymes, consists of two nonidentical subunits, proteins B1 and B2.
Britt-Marie Sjöberg +2 more
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The Anti-Sigma Factor MucA of Pseudomonas aeruginosa: Dramatic Differences of a mucA22 vs. a ΔmucA Mutant in Anaerobic Acidified Nitrite Sensitivity of Planktonic and Biofilm Bacteria in vitro and During Chronic Murine Lung Infection [PDF]
, 2019 Mucoid mucA22 Pseudomonas aeruginosa (PA) is an opportunistic lung pathogen of cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) patients that is highly sensitive to acidified nitrite (A-NO2-).
Hassett, Daniel J. +14 more
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A New Type of YumC-Like Ferredoxin (Flavodoxin) Reductase Is Involved in Ribonucleotide Reduction
mBio, 2015 The trxB2 gene, which is annotated as a thioredoxin reductase, was found to be essential for growth of Lactococcus lactis in the presence of oxygen. The corresponding protein (TrxB2) showed a high similarity with Bacillus subtilis YumC (E value = 4.0E−88)
Jun Chen +3 more
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eLife, 2018 Ribonucleotide reductases (RNRs) convert ribonucleotides into deoxyribonucleotides, a reaction essential for DNA replication and repair. Human RNR requires two subunits for activity, the α subunit contains the active site, and the β subunit houses the ...
E. Brignole +8 more
semanticscholar +1 more source
Bacillus Subtilis Class Ib Ribonucleotide Reductase: High Activity and Dynamic Subunit Interactions [PDF]
, 2013 The class Ib ribonucleotide reductase (RNR) isolated from Bacillus subtilis was recently purified as a 1:1 ratio of NrdE (α) and NrdF (β) subunits and determined to have a dimanganic-tyrosyl radical (Mn[superscript III][subscript 2]-Y·) cofactor.
Parker, Mackenzie James +2 more
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γ-H2AX kinetics as a novel approach to high content screening for small molecule radiosensitizers. [PDF]
PLoS ONE, 2012 BACKGROUND:Persistence of γ-H2AX after ionizing radiation (IR) or drug therapy is a robust reporter of unrepaired DNA double strand breaks in treated cells.
Shibo Fu +11 more
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