Results 61 to 70 of about 196,005 (260)

Taxonomic and functional shifts in the microbiome of severely obese, prediabetic patients: Ketogenic diet versus energy‐matched standard diet

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Obesity and type 2 diabetes mellitus (T2DM) are among the leading global health challenges of the 21st century. While caloric restriction remains the cornerstone of weight loss interventions, ketogenic diets (KD), characterised by low carbohydrate and high fat intake, have been shown to improve metabolic health partly by modulating the ...
June Stone, Afroditi Tripyla, Melanie C. Scalise, Maria L. Balmer, Lia Bally, Dominik M. Meinel   +5 more
wiley   +1 more source

A short peptide derived from late embryogenesis abundant proteins enhances acid tolerance in Escherichia coli via modulation of two‐component regulatory systems

The FEBS Journal, EarlyView.
Expression of the LEA‐K peptide in E. coli BL21 (DE3) improved bacterial viability under acidic stress (pH4), suggesting a protective function. RNA‐sequencing of LEA‐K‐expressing vs. non‐expressing cells revealed 283 differentially expressed genes (DEGs). In silico docking linked LEA‐K to two‐component systems (TCS) proteins (Rcs, BtsS/R, and EnvZ/OmpR)
Khaled Metwally, Shinya Ikeno
wiley   +1 more source

Structural insights into the initiation of free radical formation in the Class Ib ribonucleotide reductases in Mycobacteria

Current Research in Structural Biology
Class I ribonucleotide reductases consisting of α and β subunits convert ribonucleoside diphosphates to deoxyribonucleoside diphosphates involving an intricate free radical mechanism.
Lumbini R. Yadav, Vasudha Sharma, Maheswaran Shanmugam, Shekhar C. Mande   +3 more
doaj   +1 more source

RRM2B: An oxygen-requiring protein with a role in hypoxia

Molecular & Cellular Oncology, 2017
How tumor cells adapt and survive under hypoxia significantly impacts patient prognosis. We recently demonstrated that the oxygen-requiring ribonucleotide reductase (RNR) enzyme, which provides cells with deoxyribonucleotides, responds to limited oxygen ...
Iosifina P. Foskolou, Ester M. Hammond
doaj   +1 more source

Diversity in Overall Activity Regulation of Ribonucleotide Reductase*

Journal of Biological Chemistry, 2015
Background: Ribonucleotide reductase (RNR) makes DNA building blocks. Results: Binding of three dATP molecules to the Pseudomonas aeruginosa class I RNR α subunit inactivates the enzyme by inducing an inert α4 complex.
V. Jonna, Mikael Crona, R. Rofougaran, D. Lundin, S. Johansson, K. Brännström, B. Sjöberg, A. Hofer   +7 more
semanticscholar   +1 more source

KRP3 Stability Controls Rice Plant Architecture and Productivity via MPK3‐Mediated Phosphorylation

Plant Biotechnology Journal, EarlyView.
ABSTRACT Yield is a critical agronomic trait in cereal crops, shaped by factors like tiller and seed number, and seed weight. Understanding the factors governing these traits will help in improving the yield of plants. In this study, we identified an orphan gene, KRP3, belonging to cereal crops as a key regulator of rice plant architecture.
Gopal Banerjee, Sarvesh Jonwal, Balakrishnan Rengasamy, Uttam Pal, Dhanraj Singh, Mohit Mohit, Alok Krishna Sinha   +6 more
wiley   +1 more source

ZmTH1 Is Vital for Healthy Plant Growth and Promotes Cold/Drought Tolerance by Regulating Thiamin Diphosphate‐Dependent Metabolisms in Maize

Plant Biotechnology Journal, EarlyView.
ABSTRACT Vitamin B1 (VB1) plays a crucial role in sustaining plant health and enabling adaptive responses to environmental stress. The complex maize genome implies a sophisticated VB1 synthesis pathway, with the mechanisms by which VB1 benefits plants remaining elusive.
Tengfei Zhang, Jie Zang, Boming Yang, Qiuxia Wang, Jijun Yan, Peiyong Xin, Jinfang Chu, Huabang Chen, Zhaogui Zhang   +8 more
wiley   +1 more source

RRM1 (ribonucleotide reductase M1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on RRM1 (ribonucleotide reductase M1), with data on DNA, on the protein encoded, and where the gene is implicated.
Freeman, SN, Bepler, G
openaire   +2 more sources

Systemic Toxicity of L‐Mimosine in Rabbits: A Non‐Rodent Model for Safety Assessment

Journal of Applied Toxicology, Volume 46, Issue 2, Page 639-651, February 2026.
ABSTRACT L‐mimosine is a non‐protein amino acid primarily found in the Mimosoideae subfamily, with high concentrations in Leucaena leucocephala and Mimosa pudica. These plants are widely used in both human and animal nutrition, as well as in phytotherapeutic applications. While the toxic effects of L‐mimosine have been extensively studied in ruminants,
S. M. Ferreira, H. Zapparoli, C. S. Mussi, P. C. Maiorka, A. F. C. Andrade, S. L. Górniak, A. T. Gotardo   +6 more
wiley   +1 more source

Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer

Biochemistry, 2015
Ribonucleotide reductases (RNRs) are responsible for all de novo biosynthesis of DNA precursors in nature by catalyzing the conversion of ribonucleotides to deoxyribonucleotides. Because of its essential role in cell division, human RNR is a target for a
N. Ando, Haoran Li, E. Brignole, S. Thompson, Martin I McLaughlin, J. Page, F. Asturias, J. Stubbe, C. Drennan   +8 more
semanticscholar   +1 more source