Results 61 to 70 of about 209,934 (286)
P53 suppresses ribonucleotide reductase via inhibiting mTORC1
OncoTarget, 2017 Balanced deoxyribonucleotides pools are essential for cell survival and genome stability. Ribonucleotide reductase is the rate-limiting enzyme for the production of deoxyribonucleotides. We report here that p53 suppresses ribonucleotide reductase subunit
Zhengfu He +6 more
semanticscholar +1 more source
The pneumococcal response to oxidative stress includes a role for Rgg [PDF]
, 2009 Streptococcus pneumoniae resides in the oxygen-rich environment of the upper respiratory tract, and therefore the ability to survive in the presence of oxygen is an important aspect of its in vivo survival. To investigate how S.
Andrew, PW +4 more
core +3 more sources
Radiopharmaceuticals for Persistent or Recurrent Uterine Cervix Cancer
Frontiers in Oncology, 2019 Uterine cervix cancers pose therapeutic challenges because of an overactive ribonucleotide reductase, which provides on-demand deoxyribonucleotides for DNA replication or for a DNA damage repair response.
Charles A. Kunos +3 more
doaj +1 more source
Bacteriophage‐Induced Ribonucleotide Reductase Systems [PDF]
European Journal of Biochemistry, 1974 Infection of Escherichia coli with bacteriophage T5 caused a more than 20‐fold increase in ribonucleotide reductase activity in crude cell extracts. The phage induced the formation of a new ribonucleotide reductase and a new thioredoxin.The T5‐specific ribonucleotide reductase was defined by its ability to accept the T5‐induced thioredoxin as hydrogen ...
Ove Berglund, Staffan Eriksson
openaire +3 more sources
Methyl-hydroxylamine as an efficacious antibacterial agent that targets the ribonucleotide reductase enzyme [PDF]
, 2015 This work was supported by grants from the Spanish Ministry of Science and Innovation (Instituto de Salud Carlos III - PI10/01438), the European Regional Development Fund (FEDER), and the Generalitat de Catalunya (2009SGR-108) to EJ, and grants from the ...
Baelo, Aida +3 more
core +10 more sources
OncoTarget, 2016 There is a critical need in cancer therapeutics to identify targeted therapies that will improve outcomes and decrease toxicities compared to conventional, cytotoxic chemotherapy.
K. Goss, David J. Gordon
semanticscholar +1 more source
FEBS Letters, EarlyView.Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel +2 more
wiley +1 more source
DNA Damage Induction of Ribonucleotide Reductase [PDF]
Molecular and Cellular Biology, 1989 RNR2 encodes the small subunit of ribonucleotide reductase, the enzyme that catalyzes the first step in the pathway for the production of deoxyribonucleotides needed for DNA synthesis. RNR2 is a member of a group of genes whose activities are cell cycle regulated and that are transcriptionally induced in response to the stress of DNA damage.
Stephen J. Elledge, Ronald W. Davis
openaire +3 more sources
Advanced Functional Materials, EarlyView.Zr‐Fe MOF@Ribociclib@Herceptin (ZFRH) efficiently targets/kills Human Epidermal Growth Factor Receptor 2/Estrogen Receptor‐positive (HER2/ER+) breast cancer cells. It combats tumors by: 1) Elevating ROS, altering redox balance; 2) Inhibiting transcription; 3) Inducing pyroptosis.
Hongkun Miao +8 more
wiley +1 more source
Resveratrol, a remarkable inhibitor of ribonucleotide reductase [PDF]
FEBS Letters, 1998 Resveratrol, a natural phytoalexin found in grapes, is well known for its presumed role in the prevention of heart disease, associated with red wine consumption. We show here that it is a remarkable inhibitor of ribonucleotide reductase and DNA synthesis in mammalian cells, which might have further applications as an antiproliferative or a cancer ...
Marc Fontecave +4 more
openaire +3 more sources