Results 71 to 80 of about 196,005 (260)
Angewandte Chemie International Edition, Volume 65, Issue 5, 28 January 2026.Substituting the bridging carboxylates in diFe sulerythrin shifts the bridging ligand coordination from 1,3‐carboxylate to 1,1‐carboxylate, yielding all three diferrous bridging motifs in one protein. This shortens the Fe–Fe distance and increases reactivity with O2.
Jae‐Hun Jeoung +6 more
wiley +1 more source
Biochemistry, 2015 Two subtypes of class III anaerobic ribonucleotide reductases (RNRs) studied so far couple the reduction of ribonucleotides to the oxidation of formate, or the oxidation of NADPH via thioredoxin and thioredoxin reductase.
Yifeng Wei +5 more
semanticscholar +1 more source
DNA methyltransferase inhibitors in hematological malignancies and solid tumors
International Journal of Cancer, Volume 158, Issue 2, Page 433-461, 15 January 2026.Abstract Epigenetic modifications such as DNA methylation play a fundamental role in oncogenesis and the progression of neoplasms neoplasias. DNA methyltransferase inhibitors (DNMTi) constitute a family of therapeutic agents that impede the methylation at the 5‐position on cytosine nucleotides, thereby modulating the epigenetic regulation of tumor ...
Valentin Wenger +3 more
wiley +1 more source
Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer
Genes and Diseases, 2022 Zanwen Zuo +6 more
semanticscholar +1 more source
Advanced Science, Volume 13, Issue 1, 5 January 2026.COP9 signalosome subunit 6 (CSN6) promotes the auto‐ubiquitination and degradation of DDB1‐CUL4 associated factor 1 (DCAF1), thereby antagonizing DCAF1‐mediated ubiquitination of Nucleophosmin (NPM1). This stabilization of NPM1 enhances the ribosome biogenesis process and the translation of specific gemcitabine‐resistance proteins, ultimately driving ...
Yijing Zhang +14 more
wiley +1 more source
Thioredoxin and glutaredoxin-mediated redox regulation of ribonucleotide reductase.
World Journal of Biological Chemsitry, 2014 Ribonucleotide reductase (RNR), the rate-limiting enzyme in DNA synthesis, catalyzes reduction of the different ribonucleotides to their corresponding deoxyribonucleotides.
R. Sengupta, A. Holmgren
semanticscholar +1 more source
Metabolism‐Regulating Nanomedicines for Cancer Therapy
Advanced NanoBiomed Research, Volume 6, Issue 1, January 2026.This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley +1 more source
ChemPhysChem, Volume 27, Issue 2, January 2026.QM/MM modeling of Sulerythrin (SulE) identifies three electronic states of its diiron center, differing in protonation and bridging ligands. The results reconcile crystallographic heterogeneity and reveal how subtle electronic and structural changes govern non‐heme diiron enzyme reactivity.
Samah Moubarak, Maria Andrea Mroginski
wiley +1 more source
XRCC2 Regulates Replication Fork Progression during dNTP Alterations
Cell Reports, 2018 Summary: RAD51 paralogs are essential for maintenance of genomic integrity through protection of stalled replication forks and homology-directed repair (HDR) of double-strand breaks.
Sneha Saxena +2 more
doaj +1 more source
Unveiling the Connection: Viral Infections and Genes in dNTP Metabolism
VirusesDeoxynucleoside triphosphates (dNTPs) are crucial for the replication and maintenance of genomic information within cells. The balance of the dNTP pool involves several cellular enzymes, including dihydrofolate reductase (DHFR), ribonucleotide reductase (
Shih-Yen Lo +3 more
doaj +1 more source