Results 81 to 90 of about 196,005 (260)

Ribonucleotide reductase inhibition restores platinum-sensitivity in platinum-resistant ovarian cancer: a Gynecologic Oncology Group Study

Journal of Translational Medicine, 2012
Background The potent ribonucleotide reductase (RNR) inhibitor 3-aminopyridine-2-carboxyaldehyde-thiosemicarbazone (3-AP) was tested as a chemosensitizer for restored cisplatin-mediated cytotoxicity in platinum-resistant ovarian cancer.
Kunos Charles, Radivoyevitch Tomas, Abdul-Karim Fadi W, Fanning James, Abulafia Ovadia, Bonebrake Albert J, Usha Lydia   +6 more
doaj   +1 more source

A bioinformatic analysis of ribonucleotide reductase genes in phage genomes and metagenomes

BMC Evolutionary Biology, 2013
Ribonucleotide reductase (RNR), the enzyme responsible for the formation of deoxyribonucleotides from ribonucleotides, is found in all domains of life and many viral genomes.
Bhakti Dwivedi, Bingjie Xue, D. Lundin, R. Edwards, M. Breitbart   +4 more
semanticscholar   +1 more source

Ubiquitination and degradation of ribonucleotide reductase M1 by the polycomb group proteins RNF2 and Bmi1 and cellular response to gemcitabine.

PLoS ONE, 2014
Ribonucleotide reductase M1 (RRM1) is required for mammalian deoxyribonucleotide (dNTP) metabolism. It is the primary target of the antimetabolite drug gemcitabine, which is among the most efficacious and most widely used cancer therapeutics. Gemcitabine
Yingtao Zhang, Xin Li, Zhengming Chen, Gerold Bepler   +3 more
doaj   +1 more source

A ribonucleotide reductase inhibitor with deoxyribonucleoside‐reversible cytotoxicity [PDF]

, 2016
Mikael Crona, Paula Codó, Venkateswara Rao Jonna, Anders Hofer, Aristi P. Fernandes, Fredrik Tholander   +5 more
openalex   +1 more source

The Levels of Ribonucleotide Reductase, Thioredoxin, Glutaredoxin 1, and GSH Are Balanced in Escherichia coli K12 [PDF]

, 1996
Antonio Miranda–Vizuete, Antonio Rodríguez‐Ariza, Fermı́n Toribio, Arne Holmgren, Juan López‐Barea, Carmen Pueyo   +5 more
openalex   +1 more source

The small subunit of ribonucleotide reductase is encoded by one of the most abundant translationally regulated maternal RNAs in clam and sea urchin eggs. [PDF]

, 1985
NANCY M. STANDART, Sarah J. Bray, Eckhard George, Tim Hunt, Joan Ruderman   +4 more
openalex   +1 more source

Broad Transgenic, and Cardiac-Specific Viral Mediated, Over-Expression of Ribonucleotide Reductase Increases In Vivo Cardiac Contractility [PDF]

, 2012
F. Steven Korte, Guy L. Odom, Jin Dai, Stephen C. Kolwicz, Jacqueline N. Robinson-Hamm, Rong Tian, Stephen D. Hauschka, Jeffrey S. Chamberlain, Robert S. Weiss, Charles E. Murry, Michael Regnier   +10 more
openalex   +1 more source

In vitro anti-proliferative, and in silico ribonucleotide reductase and pharmacokinetics studies of heteroleptic silver(I), nickel(II) and copper(II) complexes of 4-methyl-3-thiosemicarbazones and ibuprofen

, 2023
S. Narasimha Bharathi, Mahendiran Dharmasivam, Sumeer Ahmed, Aziz Kalilur Rahiman   +3 more
openalex   +2 more sources

Ribonucleotide Reductase in Developing Brain

Journal of Biological Chemistry, 1972
Abstract Ribonucleotide reductase activity has been measured as a function of gestational age in the brains of the mouse, rat, chicken, and human, and in the cerebellum of rats during the first 2 weeks after birth. Some of the properties of the cerebral enzyme have been determined. The pattern of activity found in the developing brain is related to the
openaire   +2 more sources

Radicals and the Birth and Death of DNA

CHIMIA, 2001
Radicals have important functions in the enzymatic synthesis of deoxyribonucleotides and their destruction by antibiotics. The chemical basis for these reactions is that radicals dramatically speed up ionic reactions.
Bernd Giese
doaj   +2 more sources