Results 81 to 90 of about 209,934 (286)

Ribonucleotide reductase is an effective target to overcome gemcitabine resistance in gemcitabine-resistant pancreatic cancer cells with dual resistant factors

Journal of Pharmacological Sciences, 2015
Gemcitabine is widely used for pancreatic, lung, and bladder cancer. However, drug resistance against gemcitabine is a large obstacle to effective chemotherapy. Nucleoside transporters, nucleoside and nucleotide metabolic enzymes, and efflux transporters
Kentaro Minami, Yoshinari Shinsato, Masatatsu Yamamoto, Homare Takahashi, Shaoxuan Zhang, Yukihiko Nishizawa, Sho Tabata, Ryuji Ikeda, Kohich Kawahara, Kazutake Tsujikawa, Kazuo Chijiiwa, Katsushi Yamada, Shin-ichi Akiyama, Sandra Pérez-Torras, Marcal Pastor-Anglada, Tatsuhiko Furukawa, Takeda Yasuo   +16 more
doaj   +1 more source

Activation of the Class Ib Ribonucleotide Reductase by a Flavodoxin Reductase in Bacillus cereus.

Biochemistry, 2016
To reduce ribonucleotides to deoxyribonucleotides, the manganese-bound form of class Ib ribonucleotide reductase (RNR) must be activated via a pathway that involves redox protein(s).
M. Lofstad, I. Gudim, M. Hammerstad, Å. Røhr, H. Hersleth   +4 more
semanticscholar   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Photochemical Generation of a Tryptophan Radical within the Subunit Interface of Ribonucleotide Reductase [PDF]

, 2016
United States.
Brandon L. Greene, Chelsea Finkbeiner, Daniel G. Nocera, JoAnne Stubbe, Lisa Olshansky, Lunn C. A.   +5 more
core   +3 more sources

New Approaches to Investigate Novel Agents in Ewing Sarcoma: A Report From the Children's Oncology Group Bone Tumor Committee

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Outcomes for relapsed Ewing sarcoma remain consistently poor. Continued efforts to consider creative new approaches for the treatment of relapsed Ewing sarcoma are needed. The Children's Oncology Group Bone Tumor Committee convened a New Strategies for Ewing Sarcoma Task Force to systematically evaluate agents for inclusion in future Phase II ...
Jessica D. Daley, Susan L. Whiteway, Christine M. Heske, Filemon S. Dela Cruz, Sarah B. Whittle, Sarah Cohen‐Gogo, Anderson B. Collier, Ajay Gupta, Joyce Ohm, Andrew Clark, Alice Soragni, Elizabeth Lawlor, Bhuvana Setty, Patrick J. Grohar, Katie Janeway, Damon R. Reed, Emily K. Slotkin, Kelly M. Bailey   +17 more
wiley   +1 more source

Molecular structure refinement by direct fitting of atomic coordinates to experimental ESR spectra

, 2011
An attempt is made to bypass spectral analysis and fit internal coordinates of radicals directly to experimental liquid- and solid-state electron spin resonance (ESR) spectra.
Atkinson, Barone, Becke, Borbat, Brouwer, Chiang, Clark, Clore, De Alba, Dixon, Dumez, Eriksson, Freed, G.T.P. Charnock, Güntert, Hansen, Harris, Harris, Helgstrand, Hermosilla, Herrmann, Hogben, Husein Mor, Ilya Kuprov, Improta, Jensen, Jeschke, Kuprov, Kuprov, Kuprov, Liu, M. Krzystyniak, Neese, Neese, Neese, Nordlund, Pulay, Rega, Ruud, Ruud, Schlegel, Schlegel, Schwieters, Shen, Shultz, Soleilhavoup, Svistunenko, Svistunenko, Vranken   +48 more
core   +1 more source

Gene Therapy Rescues Cardiac Dysfunction in Duchenne Muscular Dystrophy Mice by Elevating Cardiomyocyte Deoxy-Adenosine Triphosphate

JACC: Basic to Translational Science, 2019
Summary: Mutations in the gene encoding for dystrophin leads to structural and functional deterioration of cardiomyocytes and is a hallmark of cardiomyopathy in Duchenne muscular dystrophy (DMD) patients.
Stephen C. Kolwicz, Jr., PhD, John K. Hall, PhD, Farid Moussavi-Harami, MD, Xiolan Chen, PhD, Stephen D. Hauschka, PhD, Jeffrey S. Chamberlain, PhD, Michael Regnier, PhD, Guy L. Odom, PhD   +7 more
doaj  

Structure-based in silico investigation of antagonists of human ribonucleotide reductase from Annona muricata

Informatics in Medicine Unlocked, 2023
Human ribonucleotide reductase (HRR) also known as ribonuceotide diphosphate reductase catalyzes the conversion of ribonucleotide to deoxyribonuceotides which is the rate limiting step in the synthesis of DNA, establishing the enzyme as a vital ...
Damilola A. Omoboyowa, Damilola S. Bodun, Jamiyu A. Saliu   +2 more
doaj  

Annexin A1‐Targeted d‐Peptide‐Monomethyl Auristatin E Conjugate Enhanced Antitumor Effect of Monomethyl Auristatin E for Chemotherapy of Prostate Cancer

The Prostate, EarlyView.
ABSTRACT Background N‐terminus 15 amino acid (MC16) of Annexin A1 (ANXA1) is an effective therapeutic target for tumors and tumor vasculature as it specifically localizes to the cell surface of tumor cells and tumor vascular endothelial cells. We identified the d‐type peptide (hpnevrs, dhp7) by mirror‐image phage display targeting l‐type MC16 and ...
Kai Ozaki, Tohru Yoneyama, Yuka Kubota, Mihoko Sutoh Yoneyama, Motohiro Nonaka, Tomonori Suzuki, Ryuma Tanaka, Chikara Ohyama, Shingo Hatakeyama   +8 more
wiley   +1 more source

The Enhanced Tumor Specificity of TG6002, an Armed Oncolytic Vaccinia Virus Deleted in Two Genes Involved in Nucleotide Metabolism

Molecular Therapy: Oncolytics, 2019
Oncolytic vaccinia viruses are currently in clinical development. However, the safety and the tumor selectivity of these oncolytic viruses must be improved.
Johann Foloppe, Juliette Kempf, Nicolas Futin, Jacqueline Kintz, Pascale Cordier, Christelle Pichon, Annie Findeli, Fabien Vorburger, Eric Quemeneur, Philippe Erbs   +9 more
doaj