Results 1 to 10 of about 17,369 (190)
Computation, 2023 In this work, we present a new way of studying the mathematical structure of the genetic code. This study relies on the use of mathematical computations involving five Fibonacci-like sequences; a few of their “seeds” or “initial conditions” are chosen ...
Tidjani Négadi
doaj +1 more source
Molecular basis for processing of topoisomerase 1-triggered DNA damage by Apn2/APE2
Cell Reports, 2022 Summary: Topoisomerase 1 (Top1) incises DNA containing ribonucleotides to generate complex DNA lesions that are resolved by APE2 (Apn2 in yeast). How Apn2 engages and processes this DNA damage is unclear.
Jessica S. Williams +7 more
doaj +1 more source
Nanopore-Based Detection of Viral RNA Modifications
mBio, 2022 The chemical modification of ribonucleotides plays an integral role in the biology of diverse viruses and their eukaryotic host cells. Mapping the precise identity, location, and abundance of modified ribonucleotides remains a key goal of many studies ...
Jonathan S. Abebe +2 more
doaj +1 more source
5'-Ribonucleotides production using 5'-phosphodiesterase from spent malt roots
Brazilian Journal of Food Technology, 2021 5'-ribonucleotides are high value-added molecules widely used in the food and pharmaceutical industries because of their bioactive properties. The present work aims to produce a composition of 5’-ribonucleotides using spent brewer’s yeast as cheap source
Edson Marcelino Alves +3 more
doaj +1 more source
MicroRNAs Induce Epigenetic Reprogramming and Suppress Malignant Phenotypes of Human Colon Cancer Cells. [PDF]
PLoS ONE, 2015 Although cancer is a genetic disease, epigenetic alterations are involved in its initiation and progression. Previous studies have shown that reprogramming of colon cancer cells using Oct3/4, Sox2, Klf4, and cMyc reduces cancer malignancy.
Hisataka Ogawa +18 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2021 Ribonucleotides (rNTPs) are predicted to be incorporated into the genome at a rate of up to 3 million times per cell division, making rNTPs the most common non-standard nucleotide in the human genome.
Nicole M. Hoitsma +3 more
doaj +1 more source
Removal of misincorporated ribonucleotides from prokaryotic genomes: an unexpected role for nucleotide excision repair. [PDF]
PLoS Genetics, 2013 Stringent steric exclusion mechanisms limit the misincorporation of ribonucleotides by high-fidelity DNA polymerases into genomic DNA. In contrast, low-fidelity Escherichia coli DNA polymerase V (pol V) has relatively poor sugar discrimination and ...
Alexandra Vaisman +6 more
doaj +1 more source
PLoS Genetics, 2017 Previous work has demonstrated the presence of ribonucleotides in human mitochondrial DNA (mtDNA) and in the present study we use a genome-wide approach to precisely map the location of these.
Anna-Karin Berglund +8 more
doaj +1 more source
Molecules, 2016 The aim of this study was to investigate the antitumor activities of Phyllanthus amarus (PHA) and its potential of herb–drug interactions with 5-Fluorouracil (5-FU). Cell viability, ribonucleotides (RNs) and deoxyribonucleotides (dRNs) levels, cell cycle
Jian-Ru Guo +6 more
doaj +1 more source
Isolation, purification and characterization of 5'-phosphodiesterase from Aspergillus fumigatus. [PDF]
PLoS ONE, 2017 5'-Phosphodiesterase (5'-PDE) catalyzes the hydrolysis of ribonucleic acid to obtain a mixture of ribonucleotides, such as 5'-guanosine monophosphate and 5'-adenosine monophosphate. In this study, a 5'-PDE was newly isolated and purified from Aspergillus
Zhiting Luo +7 more
doaj +1 more source