Results 101 to 110 of about 38,336 (323)
British Journal of Clinical Pharmacology, EarlyView.Aims Shunting (hypermethylating) thiopurine metabolism, characterized by excessive 6‐MMPR production and (sub)therapeutic 6‐TGN levels, poses a significant challenge in the treatment of inflammatory bowel disease (IBD). This study evaluates the metabolic outcomes of switching to low‐dose thiopurine with allopurinol (LDTA) or thioguanine (TG) in IBD ...
Ahmed B. Bayoumy +4 more
wiley +1 more source
BMC Plant Biology, 2023 Background The mechanisms and regulation for DNA replication in plant organelles are largely unknown, as few proteins involved in replisome assembly have been biochemically studied.
Antolin Peralta-Castro +5 more
doaj +1 more source
RNase H2, mutated in Aicardi-Goutières syndrome, promotes LINE-1 retrotransposition [PDF]
, 2018 Long INterspersed Element class 1 (LINE-1) elements are a type of abundant retrotransposons active in mammalian genomes. An average human genome contains ~100 retrotransposition-competent LINE-1s, whose activity is influenced by the combined action ...
Benitez-Guijarro, Maria +16 more
core +3 more sources
The contribution of extracellular RNA and its derived biomaterials in disease management
BMEMat, EarlyView.The implications of exRNA's biological function and the structural uniqueness of RNA help establish a close connection between RNA, material, and modern medicine. Abstract The RNA found in the circular system is known as extracellular RNA (exRNA). This kind of RNA has been found to play a biological role similar to that of a messenger. They can be used
Yu Wei +8 more
wiley +1 more source
Global Run-On sequencing to measure nascent transcription in C. elegans
STAR Protocols, 2021 Summary: Global Run-On sequencing (GRO-seq) is one of the most sensitive techniques to detect nascent transcription from RNA polymerase (Pol) at a genome-wide level.
Piergiuseppe Quarato, Germano Cecere
doaj
Formation of Abasic Oligomers in Nonenzymatic Polymerization of Canonical Nucleotides
Life, 2019 Polymerization of nucleotides under prebiotically plausible conditions has been a focus of several origins of life studies. Non-activated nucleotides have been shown to undergo polymerization under geothermal conditions when subjected to dry-wet cycles ...
Chaitanya V. Mungi +3 more
doaj +1 more source
The life cycles of cryptogams [PDF]
, 1991 Meiosis and karyogamy are recognized as control points in the life cycle of cryptogams. The control of meiosis is evidently complex and in yeast, and by analogy in all cryptogams, involves progressive gene activation.
Bell, Peter R.
core +2 more sources
Preparation of DNA interstrand cross-link repair intermediates induced by abasic sites
MethodsX, 2022 DNA interstrand cross-links (ICLs) are extremely deleterious DNA lesions, which can block different DNA transactions. A major step in ICL repair involves strand cleavage activities flanking the cross-linking site, also known as unhooking.
Jin Tang, Linlin Zhao
doaj
ChemBioChem, EarlyView.A series of 2‐substituted adenosine 5′‐O‐triphosphate derivatives is synthesized and tested as substrates for polymerases. In vitro transcription with T7 RNA polymerase, primer extension with engineered DNA polymerases, or 3′‐labelling with poly(A) polymerase are used for enzymatic synthesis of base‐modified RNA.
Ugnė Šinkevičiūtė +5 more
wiley +1 more source
Modulating pyrimidine ribonucleotide levels for the treatment of cancer
Cancer & Metabolism, 2020 By providing the necessary building blocks for nucleic acids and precursors for cell membrane synthesis, pyrimidine ribonucleotides are essential for cell growth and proliferation.
Tanzina Mollick, Sonia Laín
doaj +1 more source