Results 121 to 130 of about 38,336 (323)
Effect of hydroxyurea on ribonucleotide reductase [PDF]
Biochemical and Biophysical Research Communications, 1968 Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/33096/1/0000482 ...
openaire +4 more sources
Acute kidney injury and iron metabolism: A narrative review focusing on pathophysiology and therapy
Smart Molecules, EarlyView.Schematic illustration of acute kidney injury and iron metabolism (By Figdraw). Image for iron metabolism, including uptake, storage, utilization, export: Reproduced with permission. Abstract Acute kidney injury (AKI) represents a substantial challenge to public health and is characterized by elevated occurrence and fatality rates.
Xinyu Tan +4 more
wiley +1 more source
Transcription as a Threat to Genome Integrity [PDF]
, 2016 Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, that constitute the basis for evolution.
Aguilera López, Andrés +1 more
core +1 more source
Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components
Small Methods, EarlyView.The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu +6 more
wiley +1 more source
VIEW, EarlyView.Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding +10 more
wiley +1 more source
MazEF Homologs in Symbiobacterium thermophilum Exhibit Cross-Neutralization with Non-Cognate MazEFs
ToxinsToxin–antitoxin systems are preserved by nearly every prokaryote. The type II toxin MazF acts as a sequence-specific endoribonuclease, cleaving ribonucleotides at specific sequences that vary from three to seven bases, as has been reported in different ...
Yu-Nong Jiang +5 more
doaj +1 more source
The importance of being alkaline [PDF]
, 2003 The earliest forms of "protolife" on Earth must have been able to reproduce and replicate; it is likely that they were also cellular. How might such systems have formed?
Russell, M.J.
core +1 more source
Aging Cell, EarlyView.Multi‐ciliated cells in the infundibulum and ampulla (INF/AMP) epithelium are vacuolated in aging. Unique cellular susceptibility of the INF/AMP epithelial population and aging‐associated decline in ovarian artery circulation, which supports the ovary and INF/AMP, contribute to this region‐specific vacuolation phenotype, as a consequence of a mildly ...
Keerthana Harwalkar +10 more
wiley +1 more source
Alcohol, Clinical and Experimental Research, EarlyView.Prenatal alcohol exposure (PAE) and early‐life adversity (ELA) independently and interactively disrupted neural activity within the social behavior network in adolescent rats, with age‐ and sex‐specific effects. PAE primarily dampened amygdala activity, while ELA altered medial prefrontal cortex responses. These findings reveal how different early‐life
Parker J. Holman +5 more
wiley +1 more source