Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity
Journal of Experimental Medicine, 2012 Mouse RNase H2 is essential to remove ribonucleotides from the genome to prevent DNA damage.
B. Hiller +5 more
semanticscholar +1 more source
Ribonucleotide reductases: Essential Enzymes for bacterial life
Frontiers in Cellular and Infection Microbiology, 2014 Ribonucleotide reductase (RNR) is a key enzyme that mediates the synthesis of deoxyribonucleotides, the DNA precursors, for DNA synthesis in every living cell.
Eduard eTorrents
doaj +1 more source
INDUCTION BY AN RNA PHAGE OF AN ENZYME CATALYZING INCORPORATION OF RIBONUCLEOTIDES INTO RIBONUCLEIC ACID [PDF]
, 1963 Charles Weissmann +2 more
openalex +1 more source
Matching maternal and paternal experiences underpin molecular thermal acclimation
Molecular Ecology, EarlyView.Abstract The environment experienced by one generation has the potential to affect the subsequent one through non‐genetic inheritance of parental effects. Since both mothers and fathers can influence their offspring, questions arise regarding how the maternal, paternal and offspring experiences integrate into the resulting phenotype.
L. C. Bonzi +5 more
wiley +1 more source
TERMINAL-SEQUENCE STUDIES OF HIGH-MOLECULAR-WEIGHT RIBONUCLEIC. THE REACTION OF PERIODATE-OXIDIZED RIBONUCLEOSIDES, 5′-RIBONUCLEOTIDES AND RIBONUCLEIC ACID WITH ISONIAZID [PDF]
, 1965 John A. Hunt
openalex +1 more source
Genomic stress in diseases stemming from defects in the second brain
Neurogastroenterology &Motility, EarlyView.The enteric nervous system, a.k.a., second brain, is subject to a range of genotoxic exposures that include intrinsic oxidative stress and extrinsic agents associated with ingested foods, inflammation, and dysbiosis. Resulting DNA damage, if left unrepaired, can induce cell dysfunction or death, resulting in gut abnormalities and enteric neuropathy ...
Lobke Marie M. Mombeek +2 more
wiley +1 more source
Enzymatic Reduction of Purine Ribonucleotides. [PDF]
, 1963 Agne Larsson +4 more
openalex +1 more source
Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model [PDF]
, 2017 All DNA polymerases misincorporate ribonucleotides despite their preference for deoxyribonucleotides, and analysis of cultured cells indicates that mammalian mitochondrial DNA (mtDNA) tolerates such replication errors.
Dalla Rosa, I, holt, IJ, Spinazzola, A
core
Management of T‐cell malignancies: Bench‐to‐bedside targeting of epigenetic biology
CA: A Cancer Journal for Clinicians, EarlyView.Abstract The peripheral T‐cell lymphomas (PTCL) are the only disease for which four histone deacetylase (HDAC) inhibitors have been approved globally as single agents. Although it is not clear why the PTCL exhibit such a vulnerability to these drugs, understanding the biological basis for this activity is essential.
Ariana Sabzevari +7 more
wiley +1 more source
Cell Reports, 2017 Summary: RNA viruses pose a threat to public health that is exacerbated by the dearth of antiviral therapeutics. The RNA-dependent RNA polymerase (RdRp) holds promise as a broad-spectrum, therapeutic target because of the conserved nature of the ...
David Dulin +9 more
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