Results 151 to 160 of about 38,336 (323)

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

open access: yesChemBioChem, Volume 26, Issue 11, June 3, 2025.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout   +1 more
wiley   +1 more source

Exploring of Antidepressant Components and Mechanisms of Zhizichi Decoction: Integration of Serum Pharmacochemistry, Network Pharmacology and Anti‐inflammatory Analysis Verification

open access: yesAnalytical Science Advances, Volume 6, Issue 1, June 2025.
ABSTRACT Using LC–MS to screen and analyse the characteristics of components and biological systems is a new approach to study the pharmacological substance basis of traditional Chinese medicine, which has strong novelty in analytical science. This study analyses the antidepressant material basis of Zhizichi decoction through the integration strategy ...
Chuan Chai   +7 more
wiley   +1 more source

FLOT1 Is a Novel Serum Biomarker of Ovarian Cancer Targeted by N6‐methyladenosine Modification Inhibition

open access: yesCell Biology International, Volume 49, Issue 6, Page 674-691, June 2025.
ABSTRACT Ovarian cancer (OC) is a deadly disease and lacks a precise marker for diagnosis worldwide. Our previous work has shown the overexpression of flotillin‐1 (FLOT1) in OC tissue. To improve diagnostic sensitivity and accuracy, we evaluated the serum level of FLOT1 in OC patients and found that the serum concentration of FLOT1 as well as CA125 was
Bin Guan   +7 more
wiley   +1 more source

Therapeutic Potential of Polyphenols in Targeting Th17/Treg Balance for Intestinal Barrier Maintenance

open access: yesFood Science &Nutrition, Volume 13, Issue 6, June 2025.
ABSTRACT The integrity of the intestinal barrier is essential for overall health. Disruption of tight junction (TJs) proteins negatively affects intestinal barrier function, leading to immune imbalances and causing a variety of pathological conditions that are closely associated with the pathogenesis of multiple diseases.
Jiaojiao Fu   +3 more
wiley   +1 more source

Evaluating the Potential Adverse Effects of Favipiravir on Biochemical, Histopathological, and Spermatological Parameters in Male Rats' Testicular Tissue

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 39, Issue 6, June 2025.
ABSTRACT Favipiravir is a selective RNA polymerase inhibitor and a broad‐spectrum antiviral drug. Favipiravir reduces cell proliferation by inhibiting RNA transcription, particularly in rapidly proliferating cells such as spermatogonia. The aim of this study was to investigate the effects and mechanism of action of favipiravir (T‐705) on sperm quality ...
Ali Doğan Ömür   +6 more
wiley   +1 more source

Ibuprofen inhibits human sweet taste and glucose detection implicating an additional mechanism of metabolic disease risk reduction

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 12, Page 2682-2693, June 2025.
Background and Purpose The human sweet taste receptor, TAS1R2–TAS1R3, conveys sweet taste in the mouth and may help regulate glucose metabolism throughout the body. Ibuprofen and naproxen are structurally similar to known inhibitors of TAS1R2–TAS1R3 and have been associated with metabolic benefits.
Emily C. Hanselman   +6 more
wiley   +1 more source

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