Results 161 to 170 of about 38,336 (323)
Lnc‐TPT1‐AS1/CBP/ATIC Axis Mediated Purine Metabolism Activation Promotes Breast Cancer Progression
Cancer Science, Volume 116, Issue 6, Page 1565-1578, June 2025.Overexpression of TPT1‐AS1 could suppress the malignant phenotype and purine synthesis activation of breast cancer through competitive interaction with CBP, subsequently reducing the promoter H3K27ac signal and transcription of ATIC. Therefore, targeting the TPT1‐AS1/CBP/ATIC axis may provide a useful strategy for the treatment of patients with breast ...
Yiyun Zhang +10 more
wiley +1 more source
THE METABOLISM OF P32-LABELED RIBONUCLEOTIDES IN TISSUE SLICES AND CELL SUSPENSIONS
, 1955 Kenneth C. Leibman, Charles Heidelberger
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Bacterial purine metabolism modulates C. elegans development and stress tolerance via DAF‐16
The FEBS Journal, Volume 292, Issue 11, Page 2771-2783, June 2025.Purine metabolism is crucial for cellular function and is a conserved metabolic network from prokaryotes to humans, but remains poorly understood in metazoan. To investigate the impact of dietary components on purine metabolism and animal growth, we screened the effects of an Escherichia coli single‐gene deletion library on the growth of the nematode ...
Min Feng +3 more
wiley +1 more source
The FEBS Journal, Volume 292, Issue 11, Page 2767-2770, June 2025.The microbiota plays a major role in metazoan physiology, particularly in the intestinal tract. Nonetheless, its extreme complexity hinders functional studies. Taking advantage of the Caenorhabditis elegans and Escherichia coli model systems, Feng et al. report the physiological effect of purine biosynthesis deficiencies in E.
José Eduardo Gomes
wiley +1 more source
Studies on Synthetic Nucleotides. I. A Convenient Synthesis of Ribonucleotides.
, 1967 Bunji Shimizu +2 more
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Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.ABSTRACT Triple‐negative breast cancer (TNBC) is associated with a poor prognosis due to insufficient molecular subtyping precision and limited actionable targets. Although metabolic reprogramming underlies TNBC chemotherapy resistance, establishing metabolic subtyping systems and investigating drug sensitivity across distinct metabolic subgroups could
Jingyuan Zhang, Xuejun Sun
wiley +1 more source
Processing ribonucleotides incorporated during eukaryotic DNA replication
Nature reviews. Molecular cell biology, 2016 Jessica S. Williams, S. Lujan, T. Kunkel
semanticscholar +1 more source
ANTIBODIES SPECIFIC FOR RIBONUCLEOSIDES AND RIBONUCLEOTIDES AND THEIR REACTION WITH DNA
, 1964 Bernard F. Erlanger, Sam M. Beiser
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Journal of Integrative Plant Biology, Volume 67, Issue 6, Page 1515-1532, June 2025.A high‐quality genome sequence of the tetraploid wild oat Avena barbata provides crucial genetic information for the Avena B‐genome, allowing clarification of the evolutionary trajectories of the four subgenomes within Avena and identification of numerous key genes related to environmental adaptability, thus offering valuable resources for oat breeding
Qiang He +9 more
wiley +1 more source
Neuropathology, Volume 45, Issue 3, Page 177-201, June 2025.Oxidative stress in sporadic amyotrophic lateral sclerosis (ALS) has been evidenced by accumulation of oxidatively modified products of nucleic acids, lipids, sugars, and proteins in the motor neuron system of brains and spinal cords obtained at autopsy from the patients.
Noriyuki Shibata +6 more
wiley +1 more source