Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides
Nature Communications, 2017 While mechanisms have been proposed for the prebiotic nucleotide synthesis, these require separate (and potentially incompatible) routes for pyrimidines and purines.
Shaun Stairs +5 more
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Convergent Allostery in Ribonucleotide Reductase [PDF]
Nature Communications, 2018 AbstractRibonucleotide reductases (RNRs) use a conserved radical-based mechanism to catalyze the conversion of ribonucleotides to deoxyribonucleotides. Within the RNR family, class Ib RNRs are notable for being largely restricted to bacteria, including many pathogens, and for lacking an evolutionarily mobile ATP-cone domain that allosterically controls
Nozomi Ando +11 more
openaire +5 more sources
Detection of ribonucleotides embedded in DNA by Nanopore sequencing [PDF]
Communications BiologyRibonucleotides represent the most common non-canonical nucleotides found in eukaryotic genomes. The sources of chromosome-embedded ribonucleotides and the mechanisms by which unrepaired rNMPs trigger genome instability and human pathologies are not ...
Lavinia Grasso +8 more
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Nature Communications, 2020 DNA double-strand break repair by homologous recombination initiates with nucleolytic resection of the 5’ DNA strand at the break ends. Here, the authors reveal that the lesion context influences the action and efficiency of the long range resection ...
James M. Daley +12 more
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Deuterated nucleotides as chemical probes of RNA structure: a detailed protocol for the enzymatic synthesis of a complete set of nucleotides specifically deuterated at ribose carbons [PDF]
ScienceOpen Research, 2015 We describe here a detailed protocol for the synthesis of ribonucleotides specifically deuterated at each ribose carbon atom. We synthesized 20 specifically deuterated ribonucleotides: ATP, CTP, GTP, and UTP, each of which contained one of five ...
Azad, Robert +2 more
core +5 more sources
PCNA and Rnh1 independently participate in the protection of mitochondrial genome against UV-induced mutagenesis in yeast cells [PDF]
Scientific ReportsIn Saccharomyces cerevisiae cells, the bulk of mitochondrial DNA (mtDNA) replication is mediated by the replicative high-fidelity DNA polymerase γ. However, upon UV irradiation low-fidelity translesion polymerases: Polη, Polζ and Rev1, participate in an ...
Martyna Latoszek +3 more
doaj +2 more sources
Meat Characteristics, Expression of Myosin Heavy Chain and Metabolism-Related Genes in Thai Native Pigs [PDF]
FoodsThis study investigated the meat quality, expression of myosin heavy chain (MyHC) and metabolism-related genes, ribonucleotides and fatty acids in Longissimus thoracis of Thai native pigs (TNPs) from different geographical regions (GR).
Chanporn Chaosap +4 more
doaj +2 more sources
Ribonucleases and Ribonucleotides in Liver Tumours [PDF]
British Journal of Cancer, 1958 Reid E, Lotz F
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Click Conjugates of Artificial Ribonucleases: Sequence Specific Cleavage with Multiple Turnover [PDF]
Chemistry – A European Journal, Volume 31, Issue 30, May 27, 2025.A trisbenzimidazole catalyst was attached to central positions of DNA and DNA‐LNA oligonucleotides. The resulting conjugates bind complementary RNA strands and cleave them with multiple turnover and substrate half‐lives down to 3.5 hours. Up to 98.8% of cleavage occurs in a single site.
Sandra Weber +4 more
wiley +2 more sources
Computation, 2023 In this work, we present a new way of studying the mathematical structure of the genetic code. This study relies on the use of mathematical computations involving five Fibonacci-like sequences; a few of their “seeds” or “initial conditions” are chosen ...
Tidjani Négadi
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