Results 21 to 30 of about 38,336 (323)

Evaluation of repair activity by quantification of ribonucleotides in the genome

Genes to Cells, 2021
Ribonucleotides incorporated in the genome are a source of endogenous DNA damage and also serve as signals for repair. Although recent advances of ribonucleotide detection by sequencing, the balance between incorporation and repair of ribonucleotides has
Tetsushi Iida, N. Iida, J. Sese, Takehiko Kobayashi   +3 more
semanticscholar   +1 more source

Nanopore-Based Detection of Viral RNA Modifications

mBio, 2022
The chemical modification of ribonucleotides plays an integral role in the biology of diverse viruses and their eukaryotic host cells. Mapping the precise identity, location, and abundance of modified ribonucleotides remains a key goal of many studies ...
Jonathan S. Abebe, Ruth Verstraten, Daniel P. Depledge   +2 more
doaj   +1 more source

5'-Ribonucleotides production using 5'-phosphodiesterase from spent malt roots

Brazilian Journal of Food Technology, 2021
5'-ribonucleotides are high value-added molecules widely used in the food and pharmaceutical industries because of their bioactive properties. The present work aims to produce a composition of 5’-ribonucleotides using spent brewer’s yeast as cheap source
Edson Marcelino Alves, Joyce Faria de Souza, Szymon Macieja, Pedro de Oliva Neto   +3 more
doaj   +1 more source

MicroRNAs Induce Epigenetic Reprogramming and Suppress Malignant Phenotypes of Human Colon Cancer Cells. [PDF]

PLoS ONE, 2015
Although cancer is a genetic disease, epigenetic alterations are involved in its initiation and progression. Previous studies have shown that reprogramming of colon cancer cells using Oct3/4, Sox2, Klf4, and cMyc reduces cancer malignancy.
Hisataka Ogawa, Xin Wu, Koichi Kawamoto, Naohiro Nishida, Masamitsu Konno, Jun Koseki, Hidetoshi Matsui, Kozou Noguchi, Noriko Gotoh, Tsuyoshi Yamamoto, Kanjiro Miyata, Nobuhiro Nishiyama, Hiroaki Nagano, Hirofumi Yamamoto, Satoshi Obika, Kazunori Kataoka, Yuichiro Doki, Masaki Mori, Hideshi Ishii   +18 more
doaj   +1 more source

A Model for the Emergence of RNA from a Prebiotically Plausible Mixture of Ribonucleotides, Arabinonucleotides, and 2′-Deoxynucleotides

Journal of the American Chemical Society, 2020
The abiotic synthesis of ribonucleotides is thought to have been an essential step toward the emergence of the RNA world. However, it is likely that the prebiotic synthesis of ribonucleotides was accompanied by the simultaneous synthesis of ...
S. Kim, Lijun Zhou, Wen Zhang, D. O’Flaherty, Valeria Rondo-Brovetto, J. Szostak   +5 more
semanticscholar   +1 more source

One, No One, and One Hundred Thousand: The Many Forms of Ribonucleotides in DNA

International Journal of Molecular Sciences, 2020
In the last decade, it has become evident that RNA is frequently found in DNA. It is now well established that single embedded ribonucleoside monophosphates (rNMPs) are primarily introduced by DNA polymerases and that longer stretches of RNA can anneal ...
G. Nava, Lavinia Grasso, S. Sertic, A. Pellicioli, M. Muzi Falconi, Federico Lazzaro   +5 more
semanticscholar   +1 more source

Zn2+-dependent DNAzymes that cleave all combinations of ribonucleotides

Communications Biology, 2021
Inomata et al. isolate zinc-dependent DNAzymes with compact catalytic core sequences displaying highly versatile hydrolysis activity. The cleavable substrate variation for the DNAzymes (ZincDz2 and ZincDz2-v2) is very broad and the authors further ...
Rika Inomata, Jing Zhao, Makoto Miyagishi   +2 more
doaj   +1 more source

Nucleotide pools dictate the identity and frequency of ribonucleotide incorporation in mitochondrial DNA.

PLoS Genetics, 2017
Previous work has demonstrated the presence of ribonucleotides in human mitochondrial DNA (mtDNA) and in the present study we use a genome-wide approach to precisely map the location of these.
Anna-Karin Berglund, Clara Navarrete, Martin K M Engqvist, Emily Hoberg, Zsolt Szilagyi, Robert W Taylor, Claes M Gustafsson, Maria Falkenberg, Anders R Clausen   +8 more
doaj   +1 more source

Isolation, purification and characterization of 5'-phosphodiesterase from Aspergillus fumigatus. [PDF]

PLoS ONE, 2017
5'-Phosphodiesterase (5'-PDE) catalyzes the hydrolysis of ribonucleic acid to obtain a mixture of ribonucleotides, such as 5'-guanosine monophosphate and 5'-adenosine monophosphate. In this study, a 5'-PDE was newly isolated and purified from Aspergillus
Zhiting Luo, Yingying Fan, Qiuxia Li, Bing Han, Yang Liu, Shubo Li, Hua Qiu, Zongwen Pang   +7 more
doaj   +1 more source

Effects of Dietary Energy Density in a Fermented Total Mixed Ration Formulated with Different Ratios of Rice Straw and Cassava Pulp on 2- or 14-Day-Aged Meat Quality, Collagen, Fatty Acids, and Ribonucleotides of Native Thai Cattle Longissimus Muscle

Foods, 2022
This study investigated the effects of dietary energy density in rice straw and cassava pulp fermented total mixed ration on pH, cooking loss, Warner–Bratzler shear force (WBSF), and collagen content of 2- or 14-d-aged native Thai cattle (NTC ...
Chanporn Chaosap, Achara Lukkananukool, Sineenart Polyorach, Kritapon Sommart, Panneepa Sivapirunthep, Rutcharin Limsupavanich   +5 more
doaj   +1 more source