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Ribonucleotides and RNA Promote Peptide Chain Growth.
Angewandte Chemie, 2017All known forms of life use RNA-mediated polypeptide synthesis to produce the proteins encoded in their genes. Because the principal parts of the translational machinery consist of RNA, it is likely that peptide synthesis was achieved early in the ...
H. Griesser +5 more
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Glycinamide ribonucleotide analogue probes for glycinamide ribonucleotide transformylase
Bioorganic Chemistry, 1991Abstract Glycinamide ribonucleotide (GAR) transformylase catalyzes the conversion of glycinamide ribonucleotide and 10-formyltetrahydrofolate to formylglycinamide ribonucleotide and tetrahydrofolate. This reaction constitutes the third step in de novo purine biosynthesis.
Carol A. Caperelli, B.Bobert McKellar
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Tinkering with a viral ribonucleotide reductase
Trends in Biochemical Sciences, 2009Ribonucleotide reductase (RNR), a crucial enzyme for nucleotide anabolism, is encoded by all living organisms and by large DNA viruses such as the herpesviruses. Surprisingly, the beta-herpesvirus subfamily RNR R1 subunit homologues are catalytically inactive and their function remained enigmatic for many years.
LEMBO, David, Brune W.
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The evolution of ribonucleotide reduction
Trends in Biochemical Sciences, 1997Ribonucleotide reduction was essential for the transition from RNA to DNA by supplying deoxyribonucleotide precursors. The reaction requires free radical chemistry. Three quite different classes of ribonucleotide reductases are known today. All three are proteins containing a stable free radical amino acid, but each uses a different mechanism for its ...
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Alkylation of complementary ribonucleotides in nanoreactors
Phys. Chem. Chem. Phys., 2013The aim of the present study was to provide experimental evidence that base pairing, commonly occurring between nucleic bases in more complex supramolecular arrangements, may affect the reaction pathways associated with the alkylation of bases themselves.
ANGELICO, Ruggero +4 more
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Compartmentation of Ribonucleotides in PC-12 Cells: Free and Protein Bound Ribonucleotides
1995Pheochromocytoma is a cancer derived from the neural crest, mainly occurring at adult age. Rat pheochromocytoma PC-12 cells have an imbalance between pyrimidine ribonucleotide pools in comparison with adrenal medulla tissue1. No imbalance has been noticed between the ribonucleotide pools of the purine pathway.
A. B. P. Van Kuilenburg +6 more
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The interaction of adeninylalkycobalamins with ribonucleotide reductase
Biochimica et Biophysica Acta (BBA) - General Subjects, 1976Several structural analogs of adenosylcobalamin, containing 2, 3, 4, 5 and 6 methylene carbons instead of the ribofuranose moiety, have been synthesized and their interaction with ribonucleotide reductase from Lactobacillus leichmannii has been investigated.
H.P.C. Hogenkamp +2 more
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8-azidoadenosine and ribonucleotide reductase
Biochemical and Biophysical Research Communications, 1992Inhibitors of ribonucleotide reductase are potential antiproliferative agents, since they deplete cells from DNA precursors. Substrate nucleoside analogues, carrying azido groups at the base moiety, are shown to have strong cytostatic properties, as measured by the inhibition of the incorporation of thymidine into DNA.
Marc Fontecave +4 more
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Attachment of ribonucleotides on α-alumina as a function of pH, ionic strength, and surface loading.
Langmuir, 2015The interactions between nucleic acids and mineral surfaces have been the focus of many studies in environmental sciences, in biomedicine, as well as in origin of life studies for the prebiotic formation of biopolymers.
C. Feuillie, D. Sverjensky, R. Hazen
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Regulation of Ribonucleotide Reductase
1981Publisher Summary This chapter discusses the regulation of ribonucleotide reductase. Ribonucleotide reductase catalyzes the first unique step of DNA synthesis by converting the four ribonucleotides to the corresponding deoxyribonucleotides. Deoxyribonucleotides are highly specialized metabolites playing only limited roles apart from their function as
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