Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi-Goutières syndrome. [PDF]
, 2015 Aicardi-Goutières syndrome (AGS) is a severe childhood inflammatory disorder that shows clinical and genetic overlap with systemic lupus erythematosus (SLE).
Chédin, Frédéric +4 more
core +2 more sources
The Origin and Evolution of Ribonucleotide Reduction [PDF]
Life, 2015 Ribonucleotide reduction is the only pathway for de novo synthesis of deoxyribonucleotides in extant organisms. This chemically demanding reaction, which proceeds via a carbon-centered free radical, is catalyzed by ribonucleotide reductase (RNR). The mechanism has been deemed unlikely to be catalyzed by a ribozyme, creating an enigma regarding how the ...
Lundin, Daniel +3 more
openaire +6 more sources
Crystal structure of Schmallenberg orthobunyavirus nucleoprotein-RNA complex reveals a novel RNA sequestration mechanism [PDF]
, 2013 Schmallenberg virus (SBV) is a newly emerged orthobunyavirus (family Bunyaviridae) that has caused severe disease in the offspring of farm animals across Europe.
Bottcher, B. +4 more
core +1 more source
In search of the mRNA modification landscape in plants
BMC Plant Biology, 2019 Background Precise regulation of gene expression is indispensable for the proper functioning of organisms in both optimal and challenging conditions. The most commonly known regulative mechanisms include the modulation of transcription, translation and ...
Jagna Chmielowska-Bąk +2 more
doaj +1 more source
Ribose-Map: a bioinformatics toolkit to map ribonucleotides embedded in genomic DNA
Nucleic Acids Research, 2018 Recent advances in high-throughput sequencing techniques have made it possible to tag ribonucleoside monophosphates (rNMPs) embedded in genomic DNA for sequencing.
Alli L. Gombolay +2 more
semanticscholar +1 more source
Initial B Cell Activation Induces Metabolic Reprogramming and Mitochondrial Remodeling. [PDF]
, 2018 B lymphocytes provide adaptive immunity by generating antigen-specific antibodies and supporting the activation of T cells. Little is known about how global metabolism supports naive B cell activation to enable an effective immune response.
Ahsan, Fasih M +4 more
core +2 more sources
Ribonucleotide and R-Loop Damage in Plastid DNA and Mitochondrial DNA during Maize Development
Plants, 2023 Although the temporary presence of ribonucleotides in DNA is normal, their persistence represents a form of DNA damage. Here, we assess such damage and damage defense to DNA in plastids and mitochondria of maize.
Diwaker Tripathi +2 more
doaj +1 more source
Analytical Chemistry, 2019 Ribonucleotides analogues and their related phosphorylated metabolites play critical roles in tumor metabolism. However, determination of the endogenous ribonucleotides from complex biological matrix is still challenging due to their high structural ...
Fei-Long Liu +5 more
semanticscholar +1 more source
Raman depolarization ratios in RNA and DNA are sensitive for sugar-base coupling [PDF]
, 1995 Polarized and depolarized Raman spectra are obtained for a number of synthetic polynucleotides containing adenine, uracil, and thymine bases. The depolarization ratios are determined by two methods: (1) by dividing the -spectrum by the -spectrum and (2 ...
Benevides +17 more
core +3 more sources
Molecular basis for processing of topoisomerase 1-triggered DNA damage by Apn2/APE2
Cell Reports, 2022 Summary: Topoisomerase 1 (Top1) incises DNA containing ribonucleotides to generate complex DNA lesions that are resolved by APE2 (Apn2 in yeast). How Apn2 engages and processes this DNA damage is unclear.
Jessica S. Williams +7 more
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