Results 81 to 90 of about 38,336 (323)
Biomolecules, 2020 The catalytic active site of the Polymerization Domain (PolDom) of bacterial Ligase D is designed to promote realignments of the primer and template strands and extend mispaired 3′ ends.
Alejandro Sánchez-Salvador +1 more
doaj +1 more source
MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential
Diagnostics, 2022 Lung cancer is the dominant emerging factor in cancer-related mortality around the globe. Therapeutic interventions for lung cancer are not up to par, mainly due to reoccurrence/relapse, chemoresistance, and late diagnosis.
Javaid Ahmad Wani +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim +8 more
wiley +1 more source
Clofibrate inhibits the umami-savory taste of glutamate. [PDF]
PLoS ONE, 2017 In humans, umami taste can increase the palatability of foods rich in the amino acids glutamate and aspartate and the 5'-ribonucleotides IMP and GMP. Umami taste is transduced, in part, by T1R1-T1R3, a heteromeric G-protein coupled receptor.
Matthew Kochem, Paul A S Breslin
doaj +1 more source
Mutagenic cost of ribonucleotides in bacterial DNA
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance DNA polymerases frequently incorporate ribonucleotides in place of deoxyribonucleotides during genome replication. RNase HII is responsible for initiating the removal of ribonucleotide errors across all three domains of life. Ribonucleotides
J. Schroeder +4 more
semanticscholar +1 more source
Changes in Aphid Host Plant Diet Influence the Small-RNA Expression Profiles of Its Obligate Nutritional Symbiont, Buchnera. [PDF]
, 2019 Plants are a difficult food resource to use, and herbivorous insects have evolved a variety of mechanisms that allow them to fully exploit this poor nutritional resource. One such mechanism is the maintenance of bacterial symbionts that aid in host plant
Hansen, Allison K, Thairu, Margaret W
core +2 more sources
Possible role of human ribonuclease dicer in the regulation of R loops
FEBS Open Bio, EarlyView.R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik +2 more
wiley +1 more source
Emerging role of the pentose phosphate pathway in hepatocellular carcinoma [PDF]
, 2017 In recent years, there has been a revival of interest in metabolic changes of cancer cells as it has been noticed that malignant transformation and metabolic reprogramming are closely intertwined.
Columbano, Amedeo +2 more
core +2 more sources
ChemInform Abstract: Ribonucleotide Analogues and Their Applications
ChemInform, 1999 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Verma, Sandeep +2 more
openaire +4 more sources
FEBS Open Bio, EarlyView.ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu +6 more
wiley +1 more source