Systemic Toxicity of L‐Mimosine in Rabbits: A Non‐Rodent Model for Safety Assessment
Journal of Applied Toxicology, Volume 46, Issue 2, Page 639-651, February 2026.ABSTRACT L‐mimosine is a non‐protein amino acid primarily found in the Mimosoideae subfamily, with high concentrations in Leucaena leucocephala and Mimosa pudica. These plants are widely used in both human and animal nutrition, as well as in phytotherapeutic applications. While the toxic effects of L‐mimosine have been extensively studied in ruminants,
S. M. Ferreira +6 more
wiley +1 more source
Microcondensate‐Mediated Intracellular Infusion of mRNA Across the Plasma Membrane
Angewandte Chemie, Volume 138, Issue 1, 2 January 2026.The delivery of mRNA without lipid nanoparticles remains challenging. FcB(L17E)3‐driven microcondensates with nucleic acids, aided by short ssDNA, enable coacervate formation, actin‐dependent cytosolic infusion, and in vivo protein expression, offering a potential platform for next‐generation mRNA therapeutics and vaccination.
Yoshimasa Kawaguchi +4 more
wiley +2 more sources
Fasting as Medicine: Mitochondrial and Endothelial Rejuvenation in Vascular Aging
Aging Cell, Volume 25, Issue 2, February 2026.Aging impairs cerebrovascular health by driving mitochondrial dysfunction, oxidative stress, endothelial failure, and neurovascular uncoupling, leading to BBB breakdown and cognitive decline. In contrast, time‐restricted feeding/eating counteracts these mechanisms by restoring mitochondrial function, activating adaptive nutrient‐sensing pathways ...
Madison Milan +13 more
wiley +1 more source
Pharmacogenomics of Thiopurine Drugs: A Bench‐To‐Bedside Success Story in Thailand
Clinical and Translational Science, Volume 19, Issue 2, February 2026.ABSTRACT Thiopurine drugs are the cornerstone treatment for many diseases such as acute lymphoblastic leukemia (ALL), organ rejection, inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and other autoimmune diseases.
Mohitosh Biswas +3 more
wiley +1 more source
The Levels of Ribonucleotide Reductase, Thioredoxin, Glutaredoxin 1, and GSH Are Balanced in Escherichia coli K12 [PDF]
, 1996 Antonio Miranda–Vizuete +5 more
openalex +1 more source
Angewandte Chemie International Edition, Volume 65, Issue 5, 28 January 2026.Substituting the bridging carboxylates in diFe sulerythrin shifts the bridging ligand coordination from 1,3‐carboxylate to 1,1‐carboxylate, yielding all three diferrous bridging motifs in one protein. This shortens the Fe–Fe distance and increases reactivity with O2.
Jae‐Hun Jeoung +6 more
wiley +1 more source
A Megaplasmid-Borne Anaerobic Ribonucleotide Reductase in Alcaligenes eutrophus H16 [PDF]
, 1999 Anja Siedow +3 more
openalex +1 more source
A novel form of allosteric regulation in an ancient enzyme: mapping GTP's effect on ribonucleotide reductase with SAXS and crystallography [PDF]
, 2020 William C. Thomas +3 more
openalex +1 more source
Hydrogen Bond Network between Amino Acid Radical Intermediates on the Proton-Coupled Electron Transfer Pathway ofE. coliα2 Ribonucleotide Reductase [PDF]
, 2014 Thomas U. Nick +5 more
openalex +1 more source
Deoxyribonucleotide Metabolism in Cycling and Resting Human Fibroblasts with a Missense Mutation in p53R2, a Subunit of Ribonucleotide Reductase [PDF]
, 2011 Giovanna Pontarin +6 more
openalex +1 more source