Ribose Supplementation Alone or with Elevated Creatine Does Not Preserve High Energy Nucleotides or Cardiac Function in the Failing Mouse Heart. [PDF]
PLoS ONE, 2013 BackgroundReduced levels of creatine and total adenine nucleotides (sum of ATP, ADP and AMP) are hallmarks of chronic heart failure and restoring these pools is predicted to be beneficial by maintaining the diseased heart in a more favourable energy ...
Kiterie M E Faller +6 more
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A plastid carbohydrate carrier mediates ribose recycling from nucleotide catabolism and glucose export from starch degradation [PDF]
Nature CommunicationsIn plants, nucleotide degradation releases ribose in the cytosol. An unidentified transporter then brings the ribose into the plastids for phosphorylation. This process of ribose recycling is particularly prominent in root nodules of soybean (Glycine max)
Luisa Voß +12 more
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Dietary D-Ribose Supplementation in Sheep: Implications on Rumen, Fecal Microbiota, and Metabolic Function [PDF]
MicroorganismsThe objective of this study was to investigate the effects of dietary D-ribose supplementation on the microbial diversity, community composition, and metabolic function of the rumen and fecal microbiota in Hu sheep.
Qinghua Qiu +5 more
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Residues of the ribose binding site are required for human ribokinase activity [PDF]
Journal of Structural Biology: XRibokinase (RK) catalyzes the phosphorylation of D-ribose to ribose-5-phosphate, an essential metabolic intermediate for the pentose phosphate pathway, nucleotide biosynthesis, redox balance, and cellular energy metabolism.
Juliana C. Ferreira +7 more
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Illuminating High-Affinity ATP Binding to the Sodium-Potassium Pump Using Solid-State NMR Spectroscopy [PDF]
MoleculesProteins that span cellular membranes represent around 30% of the proteome and over 50% of drug targets. A variety of synthetic and naturally-occurring small organic molecules interact with membrane proteins and up- and down-regulate protein function ...
David A. Middleton
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Possible Enantioseparation of Racemic Ribose on Chiral Surface Formed by Adsorption of Nucleobases [PDF]
LifeThe paper proposes a putative prebiotic scenario leading to homochirality in the RNA world. In this scenario, racemic ribose, the only chiral moiety in RNA, was enantioseparated (in its pyranose form) on a chiral surface formed by the adsorption of ...
Roman Bielski, Michal Tencer
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Biomedicines, 2022 Chronic hypoxia drives vascular dysfunction by various mechanisms, including changes in mitochondrial respiration. Although endothelial cells (ECs) rely predominantly on glycolysis, hypoxia is known to alter oxidative phosphorylation, promote oxidative ...
Barbara Kutryb-Zajac +6 more
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Ribose Intake as Food Integrator: Is It a Really Convenient Practice?
Biomolecules, 2022 Reports concerning the beneficial effects of D-ribose administration in cardiovascular and muscle stressful conditions has led to suggestions for the use of ribose as an energizing food supplement for healthy people. However, this practice still presents
Roberta Moschini +5 more
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Chiral Recognition of D/L-Ribose by Visual and SERS Assessments
Molecules, 2023 Ribose is the central molecular unit in ribose nucleic acid (RNA). Ribose is a key molecule in the study of many persistent scientific mysteries, such as the origin of life and the chiral homogeneity of biological molecules.
Guohua Yao +3 more
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Frontiers in Bioengineering and Biotechnology, 2022 More than 200,000 patients with aortic diseases worldwide undergo surgical valve replacement each year, and transcatheter heart valves (THV) have been more widely used than ever before.
Xiaoke Qi +7 more
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