Results 211 to 220 of about 246,720 (281)

Ubiquitin pathway blockade reveals endogenous ADP-ribosylation marking PARP7 and AHR for degradation. [PDF]

EMBO J
Gorelik A, Đukić N, Smith R, Chatrin C, Suyari O, Matthews J, Ahel I.   +6 more
europepmc   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Structural evolution of the selectivity clamp confers ADPR-PP specificity in Namat, a phage nicotinamide ADP-ribose transferase. [PDF]

Nucleic Acids Res
Lan M, Xu L, Han Y, Cui T, Qiao Z, Teng YB, Wang N, Bao H.   +7 more
europepmc   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Isolation of cDNA encoding full‐length rat (Rattus norvegicus) poly(ADP‐ribose) polymerase [PDF]

, 1997
Sascha Beneke, Ralph G. Meyer, Alexander Bürkle   +2 more
openalex   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Crystal structures and snapshots along Tpt1-catalyzed phosphate transfer from nucleic acid to NAD^. [PDF]

Nat Commun
Cao C, Yang J, Zhang W, Chen J, Gao Y, Yao Y, Zhang Y, Li H, Li L, Luo Z, Wang C, Tang G, Cui R, Liu H, Wang Q, Huang Z, Ma J, Gan J.   +17 more
europepmc   +1 more source

Effects of the Poly(ADP-Ribose) Polymerase Inhibitor Olaparib in Cerulein-Induced Pancreatitis

, 2019
Akbar Ahmad, Aline Haas de Mello, Bartosz Szczęsny, Gábor Törő, Michela Marcatti, Nadiya Druzhyna, Lucas Liaudet, Stefano Tarantini, Reinaldo Salomão, Francisco García Soriano, Csaba Szabó   +10 more
openalex   +2 more sources

Targeting Genome Maintenance Defects of Cancers Using Chain‐Terminating Nucleoside Analogs

Cancer Science, EarlyView.
Nucleoside analogs interfere with DNA replication either by their chain‐terminating properties or by serving as DNA damage on the template. The genome maintenance pathways required to maintain cellular tolerance to each nucleoside analog vary depending on the drug.
Ryotaro Kawasumi, Rubaiat E. Tabassum, Kouji Hirota   +2 more
wiley   +1 more source

Real-time simultaneous monitoring of multiple analytes in bacterial cultures. [PDF]

Appl Environ Microbiol
Fink MM, Aljuboori Z, Klaers MK, Underdue M, Malkovsky J, Rizk SS.   +5 more
europepmc   +1 more source