Results 191 to 200 of about 234,091 (293)

Synaptic potentiation requires PARP1 activation: prevailing concepts are revisited. [PDF]

Mol Psychiatry
Cohen-Armon M, Segal M.
europepmc   +1 more source

Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry

The FEBS Journal, EarlyView.
Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero, Juan Luis Pacheco‐Garcia, Pavla Vankova, Dmitry Loginov, Isabel Quereda‐Moraleda, Jose Manuel Martin‐Garcia, Petr Man, Angel Luis Pey, Milagros Medina   +8 more
wiley   +1 more source

Critical structural perturbations of ribozyme active sites induced by 2'-O-methylation commonly used in structural studies. [PDF]

Nucleic Acids Res
Forget S, Stirnemann G.
europepmc   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Determination of Nucleotide-Nucleotide and Nucleotide-Amino Acid Binding Interactions from All-Atom Potential-of-Mean-Force Calculations. [PDF]

ACS Phys Chem Au
Feito A, Pedraza E, Cuesta E, Castro A, Rey A, Sanchez-Burgos I, Collepardo-Guevara R, Tejedor AR, Espinosa JR.   +8 more
europepmc   +1 more source

Toward understanding the catalytic mechanism for two classes of bacterial phospholipid N‐methyltransferases

The FEBS Journal, EarlyView.
Phospholipid N‐methyltransferases (Pmts) synthesize phosphatidylcholine in many bacteria. In this study, we compared the catalytic mechanisms of two bacterial Pmt classes: the Rhodobacter (R‐) and the Sinorhizobium (S‐) type. Representative enzymes for each class were derived from Rubellimicrobium thermophilum and Agrobacterium tumefaciens ...
Irina Shevyreva, Lena Sophie Fritsch, Leander Mika Koch, Anton Effing, Meriyem Aktas, Franz Narberhaus   +5 more
wiley   +1 more source

The oncogenic control of nucleotide synthesis. [PDF]

Oncogenesis
Vidal-Cruchez O, Ben-Sahra I.
europepmc   +1 more source

Decoding stress resilience in soybean: Regulatory networks and precision breeding under climate change

Journal of Integrative Plant Biology, EarlyView.
This review covers recent progress in the understanding of stress‐responsive regulatory networks in soybean and highlights emerging genomic and breeding strategies. Integrating molecular insights and precision breeding will help to accelerate the development of climate‐resilient soybean cultivars.
Ali Shahzad, Monan Sun, Shuangkang Pei, Xiaoyu Liu, Yinhe Zhang, Keheng Xu, Hongtao Gao, Yonggang Zhou, Haiyan Li   +8 more
wiley   +1 more source

Method Development for the Analysis of Carbonaceous Chondrites by Laser Desorption/Ionization and Secondary Ion Time-of-Flight Mass Spectrometry. [PDF]

J Mass Spectrom
Rados E, Frank J, Pittenauer E.
europepmc   +1 more source

Biomaterials for Reconstructive Treatment of Peri‐Implantitis

Journal of Periodontal Research, EarlyView.
Reconstructive therapy should be implemented in contained defects. Various bone filler materials with or without a barrier membrane and/or adjunctive biologics may be applied. ABSTRACT Peri‐implantitis is a pathological condition affecting the tissues surrounding dental implants, marked by inflammation of the peri‐implant connective tissue and ...
Ausra Ramanauskaite, Anton Sculean, Emilio A. Cafferata, Frank Schwarz   +3 more
wiley   +1 more source