Results 181 to 190 of about 234,091 (293)
Cancer Science, EarlyView.Patient‐derived head and neck squamous cell carcinoma (HNSCC) cells were genomically and cytogenetically characterized, revealing actionable alterations and chromosomal instability. Targeted therapies suppressed growth according to EGFR amplification or PIK3CA mutation status.
Kazue Ito +17 more
wiley +1 more source
Defining substrate specificities of human RNA capping methyltransferases through quantitative assessment of independent yet cooperative activities. [PDF]
Protein SciTaherian F +7 more
europepmc +1 more source
Cancer Science, EarlyView.In hepatocellular carcinoma, the 8q24.3 locus is frequently amplified and is associated with tumor‐specific overexpression of TONSL. TONSL promotes homologous recombination repair through RAD51, limits γH2AX accumulation and apoptosis, supports tumor growth, and its loss increases sensitivity to poly (ADP‐ribose) polymerase (PARP) inhibition.
Akinori Tsujimoto +16 more
wiley +1 more source
Targeting MARylation and DePARylation in Cancer Therapy: New Promising Therapeutic Opportunities. [PDF]
Cancers (Basel)Cabeza-Fernández V +6 more
europepmc +1 more source
Pancreatic Cancer—Advances in the Last 50 Years
World Journal of Surgery, EarlyView.
S. George Barreto +5 more
wiley +1 more source
Cancer Science, EarlyView.Schematic pathway diagram illustrating the effects of JI‐CJ002 and dabrafenib on melanoma progression. The combination of JI‐CJ002 and dabrafenib is associated with reduced B7‐H3 expression and modulation of signaling pathways implicated in melanoma progression, including JAK2/STAT3, PI3K/AKT/mTOR, and Rb/E2F1.
Sang‐Eun Lee +4 more
wiley +1 more source
Conserved-Potential-Driven Molecular Dynamics Deciphers Formose Reaction Mechanisms. [PDF]
JACS AuKan HW, Li XT, Zhu T, Xu Y, Zhang JZH.
europepmc +1 more source
Automodification of N‐terminal serine residues facilitates PARP2 release from DNA
The FEBS Journal, EarlyView.PARP2 is involved in detecting DNA damage and its N‐terminal role is largely unknown. Based on biochemical and biophysical data, our findings suggest that in the presence of HPF1, N‐terminal serine 8 and 73 are enriched in auto‐ADP‐ribosylation. Our results provide insight into the mechanistic role of PARP2 N‐terminus in the PARylation‐dependent ...
Saurabh Singh Dhakar +6 more
wiley +1 more source
Excessive poly(ADP)-ribosylation in the inflamed mucosa of pediatric celiac disease points to a novel inflammatory mechanism and therapeutic target. [PDF]
Mol Cell PediatrHaddadin TM +6 more
europepmc +1 more source
Insights into the catalytic mechanism of formate dehydrogenases from different microbial sources
The FEBS Journal, EarlyView.This integrated study combines experimental enzyme kinetics with QM/MM simulations to map the catalytic mechanisms of four formate dehydrogenases at the atomic level. This approach reveals the key determinants of catalytic efficiency and guides the rational design of biocatalysts for effective CO2 reduction—a crucial step towards sustainable ...
Laura Legnani +8 more
wiley +1 more source