Results 191 to 200 of about 694,352 (283)

RaPID Selection of Backbone Macrocyclic Peptides Targeting Akt2

Angewandte Chemie, EarlyView.
Backbone macrocyclic peptide library (BMP) library was screened against Akt2 via RaPID to discover potent BMPPakti‐3 (IC50 = 34 nM). ABSTRACT Backbone‐cyclic peptides (BMPs) are an attractive class of molecules appeared in diverse natural bioactive products. However, mRNA display technology coupled with ribosomal synthesis is intrinsically inapplicable
Koki Shinbara, Ekishin Yanagi, Ayaka Aizawa, Takayuki Katoh, Hiroaki Suga   +4 more
wiley   +2 more sources

Purification of ribosomes from human embryonic stem (hES) cells for high-resolution Cryo-EM structural studies. [PDF]

Front Mol Biosci
Hiregange DG, Fedorenko A, Ainbinder E, Bashan A, Yonath A.   +4 more
europepmc   +1 more source

Complementary multi‐omics profiling of chronic thromboembolic pulmonary hypertension reveals immune cell alterations, epigenetic changes, and genetically supported candidate genes

Animal Models and Experimental Medicine, EarlyView.
This study presents an integrative multi‐omics framework to uncover the molecular mechanisms and potential biomarkers of chronic thromboembolic pulmonary hypertension (CTEPH). Anthropometric and biochemical data were correlated using canonical correlation analysis, revealing key cardiometabolic associations. Single‐cell RNA sequencing identified immune
Xiaopeng Liu, Xia Zheng, Yajun Zhang, Yinghui Fang, Yanan Zhen   +4 more
wiley   +1 more source

Whole-cell modeling predicts alternative proteome allocation strategies in the archaeon Methanococcus maripaludis. [PDF]

Sci Rep
Kasem GS, Soliman THA, Mousa MAA, Jaheen ZF, Elsemman IE.   +4 more
europepmc   +1 more source

Mitochondrial ribosomes of neurospora crassa [PDF]

, 1979
Alberghina, Avadhani, Borst, Borst, Cammarano, Datema, de Vries, Drahos, Dure, Hallermayer, Hawley, Kaltschmidt, Kiintzel, Kiintzel, Kroon, Kuriyama, Küntzel, Küntzel, Küntzel, Lambowitz, Lambowitz, Leaver, Lizardi, Lizardi, Loening, Michel, Michel, Michel, Neupert, Neupert, Noll, Nonomura, O'Brien, Ojala, Parish, Peacock, Reijnders, Rifkin, Sala, Sebald, Solymosy, Taylor, van den Bogert, Vasiliev, Vignais, Watson   +45 more
core   +1 more source

Alternative Translation Initiation in PRKN Delays the Onset of Parkinson's Disease and Offers a Therapeutic Target

Annals of Neurology, EarlyView.
Objective Biallelic variants in PRKN cause autosomal recessive Parkinson's disease (PD) with a median age at onset of 31 years. When evaluating the 16 previously published carriers of a homozygous deletion of Exon 2 from the International Parkinson's Disease and Movement Disorder Society Gene Database (MDSGene) database, the median age at onset is ...
Arian Hach, Katja Lohmann, Manabu Funayama, Poornima J. Menon, Eva‐Juliane Vollstedt, Teresa Kleinz, Hiroyo Yoshino, Suzanne Lesage, Britta Meier, Carolyn M. Sue, Jean‐Christophe Corvol, Alexis Brice, Nobutaka Hattori, Christine Klein, Aleksandar Rakovic   +14 more
wiley   +1 more source

Photocatalytic Cross‐Coupling of Phenols and Heteroaryl Halides With Machine Learning‐Guided Reaction Prediction

Angewandte Chemie, EarlyView.
Photocatalytic cross‐coupling: A redox‐neutral photochemical method enables direct C(sp2)─C(sp2) bond formation between phenols and heteroaryl halides using an organic dye and base. Complementary radical generation allows efficient cross‐coupling in up to 91% yield. Mechanistic studies, DFT, HTE, and machine learning rationalize and predict reactivity,
Matthew C. Carson, Alice Wu, Kalyana B. Duggal, Madeline E. Rotella, Marisa C. Kozlowski   +4 more
wiley   +2 more sources

Structural modeling and docking analysis of canonical and novel resistance-associated missense mutations in Sudanese Escherichia coli. [PDF]

Sci Rep
Sage EE, Ibrahim SAE, Firdaus-Raih M, Samhoon SOA, Mohamed AAM, Ahmed TME, Saadaldin MM, Suliman OH, Mohamed O, Mohamed SB, Ali QM.   +10 more
europepmc   +1 more source

Setd1a Loss-of-function Disrupts Epigenetic Regulation of Ribosomal Genes via Altered DNA Methylation. [PDF]

Schizophr Bull
Clifton NE, Policicchio S, Walker EM, Castanho I, Bosworth ML, Saravanaraj KS, Burrage J, Hall J, Dempster EL, Hannon E, Isles AR, Mill J.   +11 more
europepmc   +1 more source

Ribosome & Translation [PDF]

Biophysical Journal, 2008
openaire   +1 more source