Results 221 to 230 of about 694,352 (283)

A Cooperative Release of Mitochondrial DNA From Platelets and Neutrophils Drives an Interferon Signature in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Mitochondria are organelles with a hypomethylated circular genome. Mitochondrial DNA (mtDNA) in the systemic circulation has been implicated in inflammation. This study investigates the role of circulating DNA in systemic sclerosis (SSc) and the cellular mechanisms governing its release.
Stavros Giaglis, André N. Tiaden, Simone Häner‐Massimi, Diego Kyburz, Cedric André, Anton Glück, Enrico Ferrero, Stuart Hawtin, Tobias Junt, Ulrich A. Walker   +9 more
wiley   +1 more source

Distinct steps of nuclear maturation of human pre-60S complexes require the activity of GTPases including GNL3L. [PDF]

Nucleic Acids Res
Thomé CC, Lemus-Diaz N, Bloch von Blottnitz KI, Tagnères S, Klein Helmkamp M, Honemann-Capito M, Hackert P, Moshkovskii S, Lenz C, Bohnsack MT, Urlaub H, Bohnsack KE.   +11 more
europepmc   +1 more source

Dysregulation of U12‐Type Splicing in Lupus Neutrophils

Arthritis &Rheumatology, EarlyView.
Objective Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and posttranscriptional changes in low‐density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron splicing ...
Luz P. Blanco, Binod Regmi, Carmelo Carmona‐Rivera, Yudong Liu, Xiantao Wang, Philip M. Carlucci, Monica M. Jackson, Zerai Manna, Sarfaraz Hasni, Markus Hafner, Hong‐Wei Sun, Mariana J. Kaplan   +11 more
wiley   +1 more source

Introduction of the Ribo-BiFC method to plants using a split mVenus approach. [PDF]

Plant Methods
Raabe K, Náprstková A, Pieters J, Torutaeva E, Jirásková V, Kahrizi Z, Mondol PC, Michailidis C, Honys D.   +8 more
europepmc   +1 more source

Transfer Learning Approaches in Bioprocess Engineering: Opportunities and Challenges

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Transfer learning (TL) has recently emerged as a promising approach to overcoming one of the key limitations of bioprocess engineering: data scarcity. By leveraging knowledge from one bioprocess to another, TL allows existing models and data sets to be reused efficiently, accelerating process development, improving prediction accuracy, and ...
Daniel Barón Díaz, Anna‐Lena Drommershausen, Alexander Grünberger, Dirk Holtmann   +3 more
wiley   +1 more source

Repurposing lusutrombopag: unveiling anti-Staphylococcus aureus activity in a novel oral thrombopoietin receptor agonist. [PDF]

BMC Microbiol
Li C, Huang X, Lan Q, Wen Z, Yu Z, Chen Z, Xu Z, Li P.   +7 more
europepmc   +1 more source

Vacancy defect‐induced electron homing breaks phosphodiester bonds for RNA depletion‐driven cancer therapy

BMEMat, EarlyView.
Illustration of 5% S‐vacancy Bi2S3 mediated phosphodiester bonds cleavage in RNA of hepatocellular carcinoma cells, which suppressing ERI3 expression, inhibiting cell proliferation and promoting apoptosis. Abstract Genome‐wide hypertranscription is a hallmark of malignant progression.
Chuncheng Yang, Zehao Shen, Guangming Xiang, Zhe Liu, Huaxin Liu, Jiabei Li, Ao Wang, Yelin Wu, Peiran Zhao, Xingwu Jiang, Jinghan Wang, Xiaoqing Jiang, Wenbo Bu   +12 more
wiley   +1 more source

Phylogenomics and Biogeography of the Eastern Asian–Eastern North American Disjunct Genus Hylodesmum (Fabaceae)

Biological Diversity, EarlyView.
Integrating data from plastid genomes, nrDNA, and 353 low‐copy nuclear genes, this study establishes a robust phylogenetic framework for Hylodesmum. This framework supports a taxonomic revision recognizing 18 species and reveals a complex pattern of bidirectional EA–ENA dispersal, with mammals as a plausible dispersal agent. ABSTRACT Phylogenomics with
Zhuqiu Song, Gang Yao, Chen Ren, Kaiwen Jiang, Dongxian Xu, Shijin Li   +5 more
wiley   +1 more source

Reduced levels of mitochondrial ribosomal protein MRPL54 does not alter Apc related adenoma formation. [PDF]

PLoS One
Spaan CN, Daniels E, Smit WL, de Boer RJ, Silva J, Vermeulen JLM, Meisner S, Muncan V, Houtkooper RH, Heijmans J.   +9 more
europepmc   +1 more source

High atmospheric pressure rescues plant growth under humidity stress: A model for climate‐resilient deep underground agriculture

Deep Underground Science and Engineering, EarlyView.
High atmospheric pressure (120 kPa) in deep underground counteracts humidity‐induced physiological stress in plants, stabilizing water balance and enhancing antioxidative defenses. This synergy boosts biomass despite elevated humidity, demonstrating sustainable deep underground agriculture potential under climate uncertainty.
Yuxin He, Linglu Xu, Xiao Tan, Wenhua Zhuang, Naiwen Li, Chao Liu, Bo Tan   +6 more
wiley   +1 more source