Results 221 to 230 of about 506,932 (296)

Spatiotemporal control of mitoribosome-mediated metabolic reprogramming in cancer: implications for heterogeneity and therapeutic targeting. [PDF]

Front Cell Dev Biol
Chen X, Wang W, Shen F, Zhao Z.
europepmc   +1 more source

Chemical Synthesis and Functional Screening of an 800 000‐Member Library Using a Peptide‐Pairing Strategy

Angewandte Chemie, EarlyView.
Chemical peptide synthesis allows the generation of structurally highly diverse compounds suited for ligand development, but current methods in parallel peptide synthesis limit the achievable library size to a few thousand. A strategy is presented based on combinatorial pairing of short peptides via disulfide linkage that enables the generation and ...
Anne Zarda, Xingwang Deng, Edward Will, Thomas Emel, Maylin Romero, Christian Heinis   +5 more
wiley   +2 more sources

Mitochondrial Genome Reduction and Accelerated Evolution in Planktonic Foraminiferans. [PDF]

Microbiologyopen
Lai HT, Lai MW, Wang TH, Ren H, Ku C.
europepmc   +1 more source

Beyond Simple Mimicry: Next‐Generation Geometric Architectures and Future Paradigms in Small‐Molecule and Macrocyclic Peptidomimetics

Angewandte Chemie, EarlyView.
Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee, Sumin Son, Jeong Yeon Yoo, Ji Hyae Lee, Meehyun Chun, Seung Bum Park   +5 more
wiley   +2 more sources

Evolution of the ribosomal exit tunnel through the eyes of the nascent chain. [PDF]

Nucleic Acids Res
Włodarski T.
europepmc   +1 more source

Broad‐Spectrum, Cell Envelope‐Active Marinocyclin Antibiotics From a Coral‐Derived Bacterium Are Effective Against Colistin‐Resistant Bacteria

Angewandte Chemie, EarlyView.
Marinocyclins, polycationic macrocyclic depsipeptides, were discovered by genome mining from the marine coral‐derived bacterium Aquimarina megaterium. The compounds have broad‐spectrum activity against gram‐positive and gram‐negative ESKAPE bacteria.
Clara Chepkirui, Sandra Silva, Jan Straetener, Chandrashekhar Padhi, Tina Keller‐Costa, Tess Lamer, Laura Reinke, Heike Brötz‐Oesterhelt, Rodrigo Costa, Jörn Piel   +9 more
wiley   +2 more sources

Genes near tRNAs are enriched in translational machinery. [PDF]

G3 (Bethesda)
West C, Dineen L, LaBella AL.
europepmc   +1 more source

A structural view on ligands at the ribosomal tunnel exit [PDF]

, 2012
Leidig, Christoph
core   +1 more source

Mrpl50 integrates glucolipotoxicity with hypoxia-inducible factor 1 alpha signaling to drive diabetic kidney disease. [PDF]

J Biol Chem
Li J, Liu R, Wang W, Zhang T, Kong Y, Jiang Q, Meng D, Cui S, Zhu S.   +8 more
europepmc   +1 more source

Knockdown of RPL28 Inhibits the Progression of Clear Cell Renal Cell Carcinoma. [PDF]

Cancer Rep (Hoboken)
Luo R, Wu G, Xie Z, Xiao Y, Zhu W, Jiang H.   +5 more
europepmc   +1 more source