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Trends in Biochemical Sciences, 2005
Fifty years is a long time. In 1955 – the year IUB (later renamed IUBMB) was established – it was known that protein synthesis is associated with ribonucleoprotein particles, which are abundant in cytoplasm, and that the small RNAs – now called tRNAs – are also involved, but no one knew what a ‘ribosome’ was because the word had not yet been coined [1].
Peter B, Moore, Thomas A, Steitz
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Fifty years is a long time. In 1955 – the year IUB (later renamed IUBMB) was established – it was known that protein synthesis is associated with ribonucleoprotein particles, which are abundant in cytoplasm, and that the small RNAs – now called tRNAs – are also involved, but no one knew what a ‘ribosome’ was because the word had not yet been coined [1].
Peter B, Moore, Thomas A, Steitz
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Trends in Cell Biology
Next to their essential role as protein production factories, ribosomes serve as molecular sensors of cell stress. Stalled and collided ribosomes trigger specific stress signaling, including the ribotoxic stress response (RSR). The RSR is initiated by the mitogen-activated protein (MAP)-3 kinase ZAKα in response to a plethora of translational ...
Anna Constance Vind +2 more
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Next to their essential role as protein production factories, ribosomes serve as molecular sensors of cell stress. Stalled and collided ribosomes trigger specific stress signaling, including the ribotoxic stress response (RSR). The RSR is initiated by the mitogen-activated protein (MAP)-3 kinase ZAKα in response to a plethora of translational ...
Anna Constance Vind +2 more
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Radioimmunoassay for ribosomes
Analytical Biochemistry, 1972Abstract A radioimmunoassay for quantitating ribosomes is presented. The assay allows for precise, efficient, and rapid estimation of ribosomes in small samples of tissue (50–100 mg).
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Nature, 1988
Fashions come and go in biochemistry. The discovery that some RNAs are enzymes is reviving interest in the long-neglected ribosome.
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Fashions come and go in biochemistry. The discovery that some RNAs are enzymes is reviving interest in the long-neglected ribosome.
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1978
Publisher Summary This chapter reviews that the normal process of translation in the ribosome is fed by energy at the expense of three chemical reactions: Ribosomecatalyzed transpeptidation, EF-Tu-mediated hydrolysis of GTP to GDP and orthophosphate, and EF-G-mediated hydrolysis of GTP.
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Publisher Summary This chapter reviews that the normal process of translation in the ribosome is fed by energy at the expense of three chemical reactions: Ribosomecatalyzed transpeptidation, EF-Tu-mediated hydrolysis of GTP to GDP and orthophosphate, and EF-G-mediated hydrolysis of GTP.
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New England Journal of Medicine, 1967
SEVERAL of the preceding Seminars in Medicine of the Beth Israel Hospital have exemplified the fact that during the past decade medicine has advanced from a firm foundation of morphology and physio...
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SEVERAL of the preceding Seminars in Medicine of the Beth Israel Hospital have exemplified the fact that during the past decade medicine has advanced from a firm foundation of morphology and physio...
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