Results 281 to 290 of about 733,505 (339)

Higher‐Level Structural Classification of Pseudomonas Cyclic Lipopeptides through Their Bioactive Conformation

Advanced Science, EarlyView.
Solution structures of a series of cyclic lipodepsipeptides from Pseudomonas reveal that these specialized metabolites adopt left‐handed alpha helical conformations of only two types, being either ‘stapled’ or ‘catch‐pole’ helix. The particular modular distribution of the biosynthetic gene clusters is found to determine the extent of their conserved ...
Benjámin Kovács, Durga Prasad, Vic De Roo, Matthias Vanheede, Penthip Muangkaew, Annemieke Madder, Monica Höfte, René De Mot, Niels Geudens, José C. Martins   +9 more
wiley   +1 more source

Integrated Machine Learning and Structure-Based Virtual Screening Identifies Natural Product Targeting 50S Ribosome Inhibitory Activity Against <i>Cutibacterium acnes</i>. [PDF]

Molecules
Liu J, Tong HHY, Zheng H, Lei MIF, Li S.
europepmc   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

Draft genome sequence of a potential probiotic <i>Pediococcus acidilactici</i> RTMP1 isolated from fecal samples of Speckled goats in South Africa. [PDF]

Microbiol Resour Announc
Modiba MR, Makete G, Alayande KA, Ngxumeshe AM, Sihlangu E, Mamphogoro TP.   +5 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Cellular aspects of the longer-lasting immunity against mouse typhoid infection afforded by the live-cell and ribosomal vaccines.

, 1986
Eisuke Kita, Masashi Emoto, Kiyoshi Yasui, N. Katsui, K Nishi, Shuzo Kashiba, S Kashiba   +6 more
openalex   +1 more source

Boosting ribosomal translation <i>via</i> ionizable lipid-hydrogel microplexes for localized mRNA therapy. [PDF]

Bioact Mater
Chen Y, He W, Ling S, Zhou Y, Chen J, Du Y, Mo R, Cui W.   +7 more
europepmc   +1 more source

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

<i>Rps19</i> ^R67∆ mutation creates a model of Diamond-Blackfan anemia and reveals downstream mediators of p53 pathway. [PDF]

Hemasphere
Kokavec J, Turková T, Schuster B, Prochazka J, Spoutil F, Jamrichová K, Holečková M, Chalupský K, Beck IM, Ruberte J, Vale M, Čermák L, Stopka T, Sedlacek R.   +13 more
europepmc   +1 more source