Results 21 to 30 of about 506,932 (296)

Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan [PDF]

, 2015
Several pathways modulating longevity and stress resistance converge on translation by targeting ribosomal proteins or initiation factors, but whether this involves modifications of ribosomal RNA is unclear.
Wilson, Iain B H, Mohr, Thomas, Mattanovich, Diethard, Breitenbach, Michael, Linder, Angela, Karl, Thomas, Amring, Manuela, Wilson, Iain B.H., Grillari-Voglauer, Regina, Polacek, Norbert, Angerer, Tina B., Rinnerthaler, Mark, Angerer, Tina B, Pircher, Andreas, Schosserer, Markus, Grillari, Johannes, Sharma, Sunny, Minois, Nadege, Breitenbach-Koller, Hannelore, Entian, Karl-Dieter, Kriegner, Albert, Steiger, Matthias, Breitenbach-Koller, Lore, Pfeifenberger, Sigrid, Dellago, Hanna, Calle-Perez, Alfonso, Brandl, Clemens, Weinhäusel, Andreas, Harreither, Eva, Kos, Martin, Sonntagbauer, Markus, Gerstl, Matthias Peter   +31 more
core   +2 more sources

Nuclear Export of Pre-Ribosomal Subunits Requires Dbp5, but Not as an RNA-Helicase as for mRNA Export. [PDF]

PLoS ONE, 2016
The DEAD-box RNA-helicase Dbp5/Rat8 is known for its function in nuclear mRNA export, where it displaces the export receptor Mex67 from the mRNA at the cytoplasmic side of the nuclear pore complex (NPC).
Bettina Neumann, Haijia Wu, Alexandra Hackmann, Heike Krebber   +3 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer. [PDF]

Mol Oncol
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Kim A, Aslam M, Torruella E, Sony A, Rahman A, Smith S, de la Parra C, Sauane M.   +7 more
europepmc   +2 more sources

Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors [PDF]

, 2014
Ribosome biogenesis is a key process for maintaining protein synthetic capacity in dividing or growing cells, and requires coordinated production of ribosomal proteins and ribosomal RNA (rRNA), including the processing of the latter.
Proud, C., Taylor, Peter M., Liu, R., Iadevaia, Valentina, Averous, Julien, Liu, R, Proud, Christopher G., Proud, CG, Taylor, P., Zhang, Z., Taylor, PM, Zhang, Z, Liu, Rui, Iadevaia, V, Zhang, Ze, Averous, J., Averous, J, Iadevaia, V.   +17 more
core   +1 more source

Broad-Range Bacterial Detection and the Analysis of Unexplained Death and Critical Illness

Emerging Infectious Diseases, 2002
Broad-range rDNA polymerase chain reaction (PCR) provides an alternative, cultivation-independent approach for identifying pathogens. In 1995, the Centers for Disease Control and Prevention initiated population-based surveillance for unexplained life ...
Simo Nikkari, Fred A. Lopez, Paul W. Lepp, Paul R. Cieslak, Stephen Ladd-Wilson, Douglas Passaro, Richard Danila, David A. Relman   +7 more
doaj   +1 more source

The human RPS4 paralogue on Yq11.223 encodes a structurally conserved ribosomal protein and is preferentially expressed during spermatogenesis. [PDF]

, 2010
BACKGROUND: The Y chromosome of mammals is particularly prone to accumulate genes related to male fertility. However, the high rate of molecular evolution on this chromosome predicts reduced power to the across-species comparative approach in identifying
Ricardo N Miguel, Nabeel A Affara, Ellis, Peter J.I., Lopes, Alexandra M., Sargent, Carole A., Alexandra M Lopes, Amorim, António, Antonio Amorim, Carole A Sargent, Peter J Ellis, Miguel, Ricardo N., Affara, Nabeel A.   +11 more
core   +7 more sources

Non‐ribosomal insights into ribosomal P2 protein in Plasmodium falciparum‐infected erythrocytes

MicrobiologyOpen, 2021
The enormous complexity of the eukaryotic ribosome has been a real challenge in unlocking the mechanistic aspects of its amazing molecular function during mRNA translation and many non‐canonical activities of ribosomal proteins in eukaryotic cells. While
Sudipta Das, Bhaskar Roy, Saswata Chakrabarty   +2 more
doaj   +1 more source

Differential polyadenylation of ribosomal RNA during post-transcriptional processing in Leishmania. [PDF]

, 2005
The protozoan parasite Leishmania belongs to the most ancient eukaryotic lineages and this is reflected in several distinctive biological features, such as eukaryotic polycistronic transcription and RNA trans-splicing.
Laurent, T., Chappuis, F., Llanos-Cuentas, A., Llanos-Cuentas, A, V. YARDLEY, F. CHAPPUIS, Laurent, T, T. LAURENT, Dujardin, J. C., Vandesompele, J, J.-C. DUJARDIN, DE DONCKER, S, S. RIJAL, Decuypere, S., S. DECUYPERE, Yardley, V, De Donckeri, S, Vandesompele, Jo, Rijal, S., J. AREVALO, Vandesompele, J., S. DE DONCKER, J. VANDESOMPELE, Yardley, V., Chappuis, F, Arevalo, J., Arevalo, J, Rijal, S, De Doncker, S., A. LLANOS-CUENTAS, Dujardin, JC, Decuypere, S   +31 more
core   +1 more source

Cic1p/Nsa3p is required for synthesis and nuclear export of 60S ribosomal subunits [PDF]

, 2003
Cic1p/Nsa3p was previously reported to be associated with the 26S proteasome and required for the degradation of specific substrates, but was also shown to be associated with early pre-60S particles and to be localized to the nucleolus.
Tollervey, D, D. Tollervey, Oeffinger, M, Bozzoni, I, M. Oeffinger, Fatica, A, BOZZONI, Irene, FATICA, Alessandro   +7 more
core   +1 more source

Recent developments in nucleic acid based techniques for use in rumen manipulation

Revista Brasileira de Zootecnia, 2009
Nucleic acid-based techniques which can be used to characterise complex microbial communities without incubation are now being employed regularly in ruminant nutrition studies.
Christopher McSweeney, Seungha Kang, Emma Gagen, Carl Davis, Mark Morrison, Stuart Denman   +5 more
doaj   +1 more source