Results 331 to 340 of about 846,528 (387)

Biosynthese der Biphenomycine, einer Familie potenter Antibiotika

Angewandte Chemie, EarlyView.
Der vollständige Biosyntheseweg der Biphenomycin‐Antibiotika wird aufgeklärt und offenbart eine einzigartige enzymatische Maschinerie mit einem bifunktionellen MNIO, einer regioselektiven Arginase, einem B12‐abhängigen rSAM für C,C‐Kupplung, Enzymen zur Hydroxylierung sowie einer zweifach spezifischen Metalloprotease.
Elisabeth Strunk, Alfred Lobert, Tatiana Khorovich, Katia M. Guzman Lucio, René Richarz, Maximilian Hohmann, Paul M. D'Agostino, Tobias A. M. Gulder   +7 more
wiley   +1 more source

RNA‐Lebendzellmikroskopie via click‐funktionalisierter TriPPPro Nucleotid‐Reporter

Angewandte Chemie, EarlyView.
Die intrazelluläre Zufuhr von trans‐Cycloocten und Bicyclo[6.1.0]nonin als sterisch anspruchsvolle Gruppen für die Diels–Alder‐Reaktion mit inversem Elektronenbedarf wurde durch die Triphosphat‐Prodrug‐Strategie (TriPPPro) erreicht. Nach der Hydrolyse innerhalb der Zelle werden die modifizierten Uridine und Cytidine metabolisch in die neu entstehende ...
J. Iven H. Knaack, Eileen List, Dörte Stalling, Vincente T. Sterrenberg, Chris Meier, Hans‐Achim Wagenknecht, Jens B. Bosse   +6 more
wiley   +1 more source

Biocontrol efficacy of Pochonia chlamydosporia against root-knot nematode Meloidogyne javanica in eggplant and its impact on plant growth. [PDF]

Sci Rep
Parveen A, Tanaka K, Khan M.
europepmc   +1 more source

Ribosomal Synthesis of Topologically Defined Thioisoindole‐Bridged Bicyclic Peptides

Angewandte Chemie, EarlyView.
A flexible in vitro translation (FIT) system‐based strategy for ribosomal synthesis of thioisoindole‐bridged bicyclic (TiB) peptides is developed. The flexizyme substrate Ac‐Ala(NtBA)Sc‐CME is efficiently incorporated into FIT to generate ribosomal peptides bearing N‐terminal Ac‐Ala(NtBA)Sc as the cyclization handle, which after mild deprotection ...
Yue Zhang, Alexander A. Vinogradov, Yin Sun, Hiroaki Suga   +3 more
wiley   +1 more source

A catalog of proteins released from <i>Asaia bogorensis</i> under two growth conditions. [PDF]

Microbiol Spectr
Manges AB, Lampe DJ.
europepmc   +1 more source

Modular Synthesis of Pyritide‐Inspired Macrocycles Featuring Bipyridine Motifs

Angewandte Chemie, EarlyView.
A pyritide‐inspired build/couple/pair strategy yields a diverse macrocycle library. This approach expands chemical space and enables the discovery of 6paW, a potent anti‐ferroptotic agent. Abstract Macrocycles represent a promising class of drug‐like scaffolds with unique structural features and the ability to engage challenging targets such as protein–
Ji Hyae Lee, Sihyeong Yi, Juhyun Bang, Hyun Choi, Seung Bum Park   +4 more
wiley   +1 more source

A selective RPL15 PROTAC degrader enhances anti-PD-1 immunotherapy in a murine melanoma tumor model. [PDF]

Oncogene
Takahashi R, Yamamoto K, Toya H, Shoji H, Kawanishi K, Momosaki K, Yabe M, Takashima K, Muromoto R, Ichikawa S, Matsuda T, Kitai Y.   +11 more
europepmc   +1 more source

Translation‐Promoting Effects of RNA Template Overhangs in the Absence of Ribosomes

Angewandte Chemie, EarlyView.
Ribosome‐free translation of an RNA sequence into a peptide sequence can be controlled by the folding of the template strand. Overhang sequences forming a triplex structure with the templating region and the peptidoyl RNA in pH‐dependent manner increase yields up to 40‐fold through entropic effects and mixed anhydride formation, allowing for controlled,
Nikolaos Giannakopoulos, Martin Rentschler, Clemens Richert   +2 more
wiley   +1 more source

Frequency and antimicrobial resistance pattern of non lactose fermenting gram negative rods in neurosurgical patients outlining aminoglycoside resistance genes. [PDF]

BMC Microbiol
Gaber SN, Abdullah AA, Osman AA, Khalil MAF, Ali ESG.   +4 more
europepmc   +1 more source

Pseudotetraivprolides from Pseudomonas entomophila Provide Insights into the Biosynthesis of Detoxin/Rimosamide‐Like Anti‐Antibiotics

Angewandte Chemie International Edition, EarlyView.
Pseudotetraivprolide is a new player among the Detoxin/Rimosamide‐like natural products! Its biosynthesis requires FabD from primary metabolism and a PipDFG complex for final‐step acetylation – unlocking its anti‐antibotic activity. Abstract Novel variants of known natural product (NP) classes can provide valuable insights into their biosynthesis ...
Edna Bode, Julia Büllesbach, Kevin Bauer, Yan‐Ni Shi, Simon Reiners, Ziheng Cui, Petra Happel, Yi‐Ming Shi, Kevin Hoffmann, Peter Grün, Bianca Pommerenke, Uli Kazmaier, Martin Grininger, Helge B. Bode   +13 more
wiley   +1 more source