Results 61 to 70 of about 699,944 (333)

The RNA helicase Dbp7 promotes domain V/VI compaction and stabilization of inter-domain interactions during early 60S assembly

Nature Communications, 2021
Early steps of large 60S ribosomal subunit biogenesis are not well understood. Here, the authors combine biochemical experiments with protein-RNA crosslinking and mass spectrometry to show that the RNA helicase Dbp7 is key player during early 60S ...
Gerald Ryan R. Aquino, Philipp Hackert, Nicolai Krogh, Kuan-Ting Pan, Mariam Jaafar, Anthony K. Henras, Henrik Nielsen, Henning Urlaub, Katherine E. Bohnsack, Markus T. Bohnsack   +9 more
doaj   +1 more source

Translational recoding as a feedback controller : systems approaches reveal polyamine-specific effects on the antizyme ribosomal frameshift [PDF]

, 2011
Peer reviewedPublisher ...
Amarantos, Amarantos, Balasundaram, Balasundaram, Bonetti, Chattopadhyay, Claudia Rato, Cohn, Cohn, Cornish-Bowden, Declan G. Bates, Delbecq, Fontaniella, Forbes, Gietz, Goldstein, Heather M. Wallace, Howard, Hryniewicz, Ian Stansfield, Ivanov, Joets, Johnston, Kim, Li, Liu, Matsufuji, Murakami, Palanimurugan, Petros, Poulin, Rodriguez-Caso, Sambrook, Sherman, Stahl, Sundararajan, Svetlana R. Amirova, Tabor, Tobias, Vimaladithan, Wallace, Wallace, White, Whitney, Williams, Xaplanteri, Yoshida   +46 more
core   +2 more sources

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

Placeholder factors in ribosome biogenesis: please, pave my way

Microbial Cell, 2017
The synthesis of cytoplasmic eukaryotic ribosomes is an extraordinarily energy-demanding cellular activity that occurs progressively from the nucleolus to the cytoplasm.
Francisco J. Espinar-Marchena, Reyes Babiano, Jesús de la Cruz   +2 more
doaj   +1 more source

N-TERMINAL PROCESSING OF RIBOSOMAL PROTEIN L27 IN STAPHYLOCOCCUS AUREUS [PDF]

, 2012
The bacterial ribosome is essential to cell growth yet little is known about how its proteins attain their mature structures. Recent studies indicate that certain Staphlyococcus aureus bacteriophage protein sequences contain specific sites that may be ...
Caufield, J. Harry
core   +1 more source

Cytokine Production but Lack of Proliferation in Peripheral Blood Mononuclear Cells from Chronic Chagas' Disease Cardiomyopathy Patients in Response to T. cruzi Ribosomal P Proteins [PDF]

, 2014
Background:Trypanosoma cruzi ribosomal P proteins, P2β and P0, induce high levels of antibodies in patients with chronic Chagas' disease Cardiomyopathy (CCC).
A Moncayo, A Rassi Jr, AC Arnholdt, Alcinette Buying, ARL Teixeira, AS de Melo, Augusto Atienza, B Zingales, C Aznar, C Chen, C Junqueira, C Smulski, Carlos A. Buscaglia, Clemencia Pinilla, CR De Marchi, E Cunha-Neto, E Mahler, E Mahler, E Olivares Fontt, E Olivares Fontt, E Roffê, EA Mesri, EB Gomez, F Kierszenbaum, F Nagajyothi, GE Cánepa, Graciela Perez Prados, GV Levy, I Ferrari, J Scharfstein, J Zhu, JA Fiuza, JAS Gomes, JC Coura, JM Burgos, JM Di Noia, JR Coura, K Elkon, Karina A. Gómez, KM Bonney, Laura M. Tasso, LC Abel, M Juri Ayub, M Ribeirao, MA Zacks, Mauricio Martins Rodrigues, MB Rosenbaum, MJ Morato, MV Elizari, NA Giraldo, P Lopez Bergami, P Lopez-Bergami, PA Chiale, Pablo Chiale, Radleigh Santos, RCG Fares, Ricardo Bonato, S Brandariz, S de Barros-Mazon, S Muller, Silvia A. Longhi, SL Topalian, V Judkowski, V Michailowsky, V Schultena, Valeria A. Judkowski, Virginia Balouz, VMB Lorena, WO Dutra, WO Dutra, WO Dutra, WO Dutra, WR Cuna, Y Belkaid, Y Morán-Utrera, Y Shi   +75 more
core   +4 more sources

Characterization of ribosome heterogeneity during endothelial to hematopoietic transition

FEBS Open Bio, EarlyView.
The panorama of ribosome heterogeneity during embryonic hematopoiesis has not yet been portrayed. In this study, utilizing dual‐omics data, the heterogenous dynamic of ribosome during endothelial‐to‐hematopoietic transition has been systemically described. Moreover, stage‐specific upregulation and peripheral localization of RPL27 and RACK1 in hemogenic
Xitong Tian, Di Liu, Bing Liu, Yu Lan, Jie Zhou   +4 more
wiley   +1 more source

Ribosomal Antibiotics: Contemporary Challenges

Antibiotics, 2016
Most ribosomal antibiotics obstruct distinct ribosomal functions. In selected cases, in addition to paralyzing vital ribosomal tasks, some ribosomal antibiotics are involved in cellular regulation.
Tamar Auerbach-Nevo, David Baram, Anat Bashan, Matthew Belousoff, Elinor Breiner, Chen Davidovich, Giuseppe Cimicata, Zohar Eyal, Yehuda Halfon, Miri Krupkin, Donna Matzov, Markus Metz, Mruwat Rufayda, Moshe Peretz, Ophir Pick, Erez Pyetan, Haim Rozenberg, Moran Shalev-Benami, Itai Wekselman, Raz Zarivach, Ella Zimmerman, Nofar Assis, Joel Bloch, Hadar Israeli, Rinat Kalaora, Lisha Lim, Ofir Sade-Falk, Tal Shapira, Leena Taha-Salaime, Hua Tang, Ada Yonath   +30 more
doaj   +1 more source