Results 71 to 80 of about 694,352 (283)

The ribosome modulates folding inside the ribosomal exit tunnel

Communications Biology, 2021
Wruck et al. investigate the folding of the small zinc-finger domain ADR1a inside and at the vestibule of the ribosomal tunnel, using optical tweezers, single-molecule FRET, and molecular dynamics simulations.
Florian Wruck, Pengfei Tian, Renuka Kudva, Robert B. Best, Gunnar von Heijne, Sander J. Tans, Alexandros Katranidis   +6 more
doaj   +1 more source

Active role of elongation factor G in maintaining the mRNA reading frame during translation. [PDF]

, 2019
During translation, the ribosome moves along the mRNA one codon at a time with the help of elongation factor G (EF-G). Spontaneous changes in the translational reading frame are extremely rare, yet how the precise triplet-wise step is maintained is not ...
Belardinelli, R., Bock, L., Grubmüller, H., Peng, B., Peske, F., Rodnina, M.   +5 more
core   +2 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Principles of cellular resource allocation revealed by condition-dependent proteome profiling

eLife, 2017
Growing cells coordinate protein translation with metabolic rates. Central to this coordination is ribosome production. Ribosomes drive cell growth, but translation of ribosomal proteins competes with production of non-ribosomal proteins.
Eyal Metzl-Raz, Moshe Kafri, Gilad Yaakov, Ilya Soifer, Yonat Gurvich, Naama Barkai   +5 more
doaj   +1 more source

N-TERMINAL PROCESSING OF RIBOSOMAL PROTEIN L27 IN STAPHYLOCOCCUS AUREUS [PDF]

, 2012
The bacterial ribosome is essential to cell growth yet little is known about how its proteins attain their mature structures. Recent studies indicate that certain Staphlyococcus aureus bacteriophage protein sequences contain specific sites that may be ...
Caufield, J. Harry
core   +1 more source

Environmental shaping of codon usage and functional adaptation across microbial communities. [PDF]

, 2013
Microbial communities represent the largest portion of the Earth's biomass. Metagenomics projects use high-throughput sequencing to survey these communities and shed light on genetic capabilities that enable microbes to inhabit every corner of the ...
Achtman, Altschul, Arumugam, Boto, Botzman, Bruggemann, Burke, Caro-Quintero, Chen, Diene, Donner, Foerstner, Forsberg, Gill, Hershberg, Horvath, Hunyadkurti, Huson, Ikemura, István Nagy, Jensen, Johnson, Kanaya, Kanehisa, Karlin, Keeling, Keller, Kristian Vlahoviček, Kuo, Larimer, Malmstrom, Martin, Maša Roller, McDaniel, McDowell, Mira, Myers, Oda, Plotkin, R Development Core Team, Retchless, Rocha, Sharp, Sharp, Sowell, Staley, Supek, Supek, Tatusov, Tettelin, Tina Perica, Tringe, Tuller, Tuller, Tuller, Turnbaugh, Tyson, Vedran Lucić, Venter, Verberkmoes, Vieira-Silva, Whitman, Willenbrock, Wilmes   +63 more
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

RNA polymerase I mutant affects ribosomal RNA processing and ribosomal DNA stability

RNA Biology
Transcription is a major contributor to genomic instability. The ribosomal RNA (rDNA) gene locus consists of a head-to-tail repeat of the most actively transcribed genes in the genome.
Christophe Normand, Christophe Dez, Lise Dauban, Sophie Queille, Sarah Danché, Sarra Abderrahmane, Frederic Beckouet, Olivier Gadal   +7 more
doaj   +1 more source

Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia. [PDF]

, 2018
Deficiency of ribosomal proteins (RPs) leads to Diamond Blackfan Anemia (DBA) associated with anemia, congenital defects, and cancer. While p53 activation is responsible for many features of DBA, the role of immune system is less defined.
Bibikova, Elena, Danilova, Nadia, Lin, Shuo, Sakamoto, Kathleen M, Wilkes, Mark, Youn, Min-Young   +5 more
core   +2 more sources

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source