Results 181 to 190 of about 2,892,023 (342)

Combined Long‐Read Genome and Transcriptome Sequencing Establishes Novel Variants in MEGF8 as the Cause for Carpenter Syndrome Type 2

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Carpenter syndrome type 2 (CRPT2) is a rare autosomal recessive disease mainly characterized by craniosynostosis and polysyndactyly. CRPT2 is the rarer subtype of Carpenter syndrome (CRPTS) and is caused by biallelic variants in the multiple epidermal growth factor‐like domains 8 gene (MEGF8).
Kiana Rashidi, Bhavi P. Modi, Phillip A. Richmond, Massimo Mangino, Loryn Byres, Cassie McDonald, Joshua Dalmann, Simran Samra, Kate L. Del Bel, Anna Lehman, Jessica L. Zambonin, Stuart E. Turvey   +11 more
wiley   +1 more source

RaPID Selection of Backbone Macrocyclic Peptides Targeting Akt2

Angewandte Chemie, EarlyView.
Backbone macrocyclic peptide library (BMP) library was screened against Akt2 via RaPID to discover potent BMPPakti‐3 (IC50 = 34 nM). ABSTRACT Backbone‐cyclic peptides (BMPs) are an attractive class of molecules appeared in diverse natural bioactive products. However, mRNA display technology coupled with ribosomal synthesis is intrinsically inapplicable
Koki Shinbara, Ekishin Yanagi, Ayaka Aizawa, Takayuki Katoh, Hiroaki Suga   +4 more
wiley   +2 more sources

Quantitative trait loci mapping reveals candidate pathways regulating cell cycle duration in \u3cem\u3ePlasmodium falciparum\u3c/em\u3e

, 2010
Background: Elevated parasite biomass in the human red blood cells can lead to increased malaria morbidity. The genes and mechanisms regulating growth and development of Plasmodium falciparum through its erythrocytic cycle are not well understood.
Ferdig, Michael T., Reilly Ayala, Heather B., Siwo, Geoffrey, Wacker, Mark A   +3 more
core  

Altered Nasal Microbiota in Sinonasal Tumors: A Comparative Analysis of Malignant and Benign Sinonasal Tumors

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Although shifts in nasal microbiota have been well‐documented in inflammatory upper airway conditions, microbiota tumor‐associated alterations remain uncharacterized. This study is the first to compare sinonasal microbiota profiles of patients with malignant tumors (MT), benign tumors (BT), and controls, offering insights into tumor‐
Evan A. Patel, Phillip A. Engen, Glen D. Souza, Sarah Khalife, Donyea Moore, Lauren Kret, Pedro Escobedo, Stefan J. Green, Ankur Naqib, Peter Filip, Peter Papagiannopoulos, Bobby A. Tajudeen, Mahboobeh Mahdavinia, Pete S. Batra   +13 more
wiley   +1 more source

Complementary multi‐omics profiling of chronic thromboembolic pulmonary hypertension reveals immune cell alterations, epigenetic changes, and genetically supported candidate genes

Animal Models and Experimental Medicine, EarlyView.
This study presents an integrative multi‐omics framework to uncover the molecular mechanisms and potential biomarkers of chronic thromboembolic pulmonary hypertension (CTEPH). Anthropometric and biochemical data were correlated using canonical correlation analysis, revealing key cardiometabolic associations. Single‐cell RNA sequencing identified immune
Xiaopeng Liu, Xia Zheng, Yajun Zhang, Yinghui Fang, Yanan Zhen   +4 more
wiley   +1 more source

The EHMT2-MBLAC2 axis suppresses ribosomal DNA transcription in response to nucleolar DNA damage. [PDF]

Cell Death Dis
Wang C, Lu Q, Cao L, Zeng S, Gao Z, Yang Y, Liu X, Gao S, Dong C.   +8 more
europepmc   +1 more source

Karyotypes and Physical Mapping of Ribosomal DNA with Oligo-Probes in Eranthis sect. Eranthis (Ranunculaceae). [PDF]

Plants (Basel), 2023
Mitrenina EY, Alekseeva SS, Badaeva ED, Peruzzi L, Artemov GN, Krivenko DA, Pinzani L, Aytaç Z, Çeçen Ö, Baasanmunkh S, Choi HJ, Mesterházy A, Tashev AN, Bancheva S, Lian L, Xiang K, Wang W, Erst AS.   +17 more
europepmc   +1 more source

Ribozyme für die RNA‐katalysierte Methylierung und Markierung von RNA

Angewandte Chemie, EarlyView.
Ribozyme sind vielseitige Werkzeuge für die präzise Modifikation von RNA. Das Reaktionsspektrum in‐vitro‐selektierter Ribozyme reicht vom Einbau funktioneller Gruppen und Fluorophoren bis zu natürlichen RNA‐Methylierungen. Dieser Übersichtsartikel präsentiert Cofaktor‐abhängige Ribozyme für die positionsgenaue Markierung und Modifikation von RNA ...
Carolin P. M. Scheitl, Claudia Höbartner   +1 more
wiley   +1 more source

rDNAcaller: a fast and robust pipeline to call ribosomal DNA variants. [PDF]

NAR Genom Bioinform
Ramirez JM, Oliveros W, García-Pérez R, Jimenez-Lupiañez A, Shah A, Perez-Cano P, Reese F, Vazquez M, Melé M.   +8 more
europepmc   +1 more source

The Epigenetic Pathways to Ribosomal DNA Silencing

Microbiology and Molecular Reviews, 2016
R. Srivastava, Rashmi Srivastava, S. Ahn
semanticscholar   +1 more source