Results 241 to 250 of about 523,023 (283)

Tumor‐educated platelets in cancer diagnostics and prognostics: A critical appraisal and roadmap for clinical translation

International Journal of Cancer, EarlyView.
Abstract Tumor‐educated platelets (TEPs) are emerging as a compelling frontier in liquid biopsy, functioning as dynamic, systemic sensors that sequester and process tumor‐derived biomolecules. This interaction imprints an integrated molecular signature of malignancy—spanning the transcriptome, proteome, lipidome, and crucially, the captured genome ...
Whi‐An Kwon, Min‐Kyung Lee, Eunyong Ahn, Heeyeon Kim, Yong Sang Song, Taejin Ahn   +5 more
wiley   +1 more source

A useful PCR primer set for the ectomycorrhizal fungus Tricholoma matsutake in wild pine rhizosphere based on the nuclear ribosomal DNA IGS2 sequence. [PDF]

Mycoscience
Misawa H, Tateishi Y, Horimai Y, Mizuno A, Hida F, Furukawa H, Kobayashi H, Kawai M, Yamanaka T, Fukuda M, Yamada A.   +10 more
europepmc   +1 more source

Targeting Microbiome Metabolites: Reshaping Immunotherapy and Clinical Management Strategies for Colorectal Cancer

iMetaMed, EarlyView.
The occurrence and progression of colorectal cancer are intricately linked to metabolites produced by the gut microbiota. Metabolites generated by pathogenic microbial communities can promote colorectal cancer development by reshaping the immune microenvironment.
Xinrui Yang, Ke Zhang, Lijie Xia, Jinyao Li   +3 more
wiley   +1 more source

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

Interdisciplinary Medicine, EarlyView.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li   +12 more
wiley   +1 more source

Achieving superior therapeutic effects on methicillin‐resistant Staphylococcus aureus infection via simple sulfonation process for preparing zwitterionic photosensitizer

Interdisciplinary Medicine, EarlyView.
The sulfonated zwitterionic photosensitizer (PYSO3) is synthesized by reacting maleic anhydride derivatives with 4‐aminopyridine to form PY, followed by sulfonation with 1,4‐butane sultone. It exhibits both photothermal and photodynamic properties, enabling effective eradication of MRSA and biofilms, as well as promoting wound healing in mice ...
Changxu Zhu, Yin Li, Qiyun Deng, Ruixin Guo, Yu Huang, Wenyan Guo, Xi Chen, Ben Zhong Tang, Zhiming Wang, Lidan Chen, Zhaohui Sun   +10 more
wiley   +1 more source

Dextran sodium sulfate confounds causal role of periodontitis in inflammatory bowel disease

Journal of Periodontology, EarlyView.
Abstract Background Emerging evidence supports a bidirectional link between periodontitis and inflammatory bowel disease (IBD). To investigate this relationship, experimental models commonly use dextran sodium sulfate (DSS) to induce colitis. However, DSS is presumed to selectively affect the colon, and its potential off‐target effects on the oral ...
Himanshi Tanwar, Jeba Mercy Gnanasekaran, Niyant Ganesh, Cindy Zhou, Amy Plotkin, Giacomo Baima, Massimo Costalonga, Fenfen Zhou, Hanping Feng, Priyam Jani, Jean‐Pierre Raufman, Vivek Thumbigere‐Math   +11 more
wiley   +1 more source

The influence of ultra‐processed foods on gut microbiome and inflammatory markers in schoolchildren from Northeastern Brazil

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objective This study investigated the relationship between the consumption of ultra‐processed foods (UPF), dietary profile, and inflammation on the intestinal microbiome in children. Methods A cross‐sectional study was conducted using data from a community‐based controlled trial involving 82 children aged 7–11 years enrolled in public schools ...
Cristiane Cosmo Silva‐Luis, Paulo César Trindade da Costa, Vinicius José Baccin Martins, José Luiz de Brito Alves   +3 more
wiley   +1 more source

Phytochemical content, antioxidant and antibacterial properties of Typhonium flagelliforme cultivated via soil and hydroponic methods

JSFA reports, EarlyView.
Abstract Background Typhonium flagelliforme is a medicinal herb in the Araceae family, widely distributed in Southeast Asia. This study aimed to evaluate the effects of hydroponic and soil‐based cultivation systems on the phytochemical content and bioactivity of T. flagelliforme. Results Using liquid chromatography‐mass spectrometry (LC‐MS) analysis, 9
Yen Ning Lee, Norsharina Md Saad, Siti Rokhiyah Ahmad Usuldin, Seetha Jaganathan King, Wee Sim Choo   +4 more
wiley   +1 more source

Loganin, an Iridoid Glycoside, Alleviates Paclitaxel‐Induced Skeletal Muscle Toxicity by Enhancing Mitochondrial Function, Boosting Antioxidant Defenses, and Reducing Cellular Senescence

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Mitochondrial dysfunction and energy imbalance caused by chemotherapy are key contributors to skeletal muscle atrophy, which severely impacts the quality of life in cancer patients. Paclitaxel, a commonly used chemotherapeutic agent, is known to promote muscle wasting and cellular senescence, largely by impairing mitochondrial function.
Yu‐Fan Chuang, Cai‐Rong Wu, Wan‐Hsuan Chang, Ying‐Jung Su, Hung‐Te Hsu, Fan‐Li Lin, Yi‐Ching Lo   +6 more
wiley   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source