Results 281 to 290 of about 2,892,023 (342)

CRISPR‐Cas9 Genome‐Wide Screening in Paediatric Cancer: Functional Genomics for Target Discovery and the Improvement of Existing Therapies

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT CRISPR‐Cas9 genome‐wide screening has been instrumental towards identifying novel targets for drug discovery in cancer research. However, much of this research has centred specifically on adult cancers, with paediatric cancers being underserviced by current research and screening.
Steven He   +2 more
wiley   +1 more source

Amanita theophili sp. nov. (Amanitaceae) from central Mexico

open access: yesNordic Journal of Botany, EarlyView.
Amanita theophili sp. nov., a member of Amanita sect. Amidella (Amanitaceae), is described from temperate pine‐oak forests in Morelos, central Mexico. Morphological features and phylogenetic analyses based on ITS and 28S rDNA sequences confirm its distinct taxonomic status. The new species is morphologically similar to A. peckiana and A.
Evangelina Pérez‐Silva   +1 more
wiley   +1 more source

Ribosomal DNA instability and genome adaptability

Chromosome Research, 2019
Ribosomes are large, multi-subunit ribonucleoprotein complexes, essential for protein synthesis. To meet the high cellular demand for ribosomes, all eukaryotes have numerous copies of ribosomal DNA (rDNA) genes that encode ribosomal RNA (rRNA), usually far in excess of the requirement for ribosome biogenesis.
Devika Salim, J. Gerton
semanticscholar   +3 more sources

Chromatin states at ribosomal DNA loci.

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013
Eukaryotic transcription of ribosomal RNAs (rRNAs) by RNA polymerase I can account for more than half of the total cellular transcripts depending on organism and growth condition. To support this level of expression, eukaryotic rRNA genes are present in multiple copies.
Stephan Hamperl   +5 more
semanticscholar   +3 more sources

Circular ribosomal DNA and ribosomal DNA: replication in somatic amphibian cells

Chromosoma, 1975
Pulse labelled rDNA from cultured somatic cells of Xenopus laevis was examined by electron microscope autoradiography. The pattern of replication closely resembles that of bulk chromosomal DNA and differs considerably from rDNA synthesis during amplification in the oocyte.
J D, Rochaix, A P, Bird
openaire   +2 more sources

Heterogeneity in cucumber ribosomal DNA

Theoretical and Applied Genetics, 1986
Restriction and hybridization analysis of cucumber native ribosomal (r) DNA purified from actinomycin-D/CsCl gradients suggested that the repeat units were heterogeneous in both length and sequence. Several full length rDNA repeat units were cloned and five are described which account for all the EcoR I and Xba I fragments present in native DNA. One of
T A, Kavanagh, J N, Timmis
openaire   +2 more sources

Ribosomal DNA of Caenorhabditis elegans

Journal of Molecular Biology, 1981
Abstract We have characterized the organization of the genes coding for 18 S, 5·8 S and 26 S ribosomal RNAs in the nematode Caenorhabditis elegans . These ribosomal genes, present in about 55 copies per haploid genome, alternate in a repeating tandem array.
J G, Files, D, Hirsh
openaire   +2 more sources

Testing and using complete plastomes and ribosomal DNA sequences as the next generation DNA barcodes in Panax (Araliaceae)

Molecular Ecology Resources, 2019
Complete plastid genome (plastome) sequences and nuclear ribosomal DNA (nrDNA) regions have been proposed as candidates for the next generation of DNA barcodes for plant species discrimination.
Yunheng Ji   +7 more
semanticscholar   +1 more source

Ribosomal DNA in the Rat

Nature, 1969
THE amount of DNA complementary to ribosomal RNA (rDNA) has been shown to be constant in several tissues varying in rRNA synthesis1,2. There is, however, a dramatic exception to this in amphibian and insect oocytes3–5, where amplification of the rDNA occurs and results in high rates of rRNA synthesis during oogenesis6.
J, Mohan, A, Dunn, L, Casola
openaire   +2 more sources

Non-canonical DNA structures in the human ribosomal DNA

Histochemistry and Cell Biology, 2023
Non-canonical structures (NCS) refer to the various forms of DNA that differ from the B-conformation described by Watson and Crick. It has been found that these structures are usual components of the genome, actively participating in its essential functions.
Evgeny, Smirnov   +4 more
openaire   +2 more sources

Home - About - Disclaimer - Privacy