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ABSTRACT CRISPR‐Cas9 genome‐wide screening has been instrumental towards identifying novel targets for drug discovery in cancer research. However, much of this research has centred specifically on adult cancers, with paediatric cancers being underserviced by current research and screening.
Steven He +2 more
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Amanita theophili sp. nov. (Amanitaceae) from central Mexico
Amanita theophili sp. nov., a member of Amanita sect. Amidella (Amanitaceae), is described from temperate pine‐oak forests in Morelos, central Mexico. Morphological features and phylogenetic analyses based on ITS and 28S rDNA sequences confirm its distinct taxonomic status. The new species is morphologically similar to A. peckiana and A.
Evangelina Pérez‐Silva +1 more
wiley +1 more source
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Ribosomal DNA instability and genome adaptability
Chromosome Research, 2019Ribosomes are large, multi-subunit ribonucleoprotein complexes, essential for protein synthesis. To meet the high cellular demand for ribosomes, all eukaryotes have numerous copies of ribosomal DNA (rDNA) genes that encode ribosomal RNA (rRNA), usually far in excess of the requirement for ribosome biogenesis.
Devika Salim, J. Gerton
semanticscholar +3 more sources
Chromatin states at ribosomal DNA loci.
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013Eukaryotic transcription of ribosomal RNAs (rRNAs) by RNA polymerase I can account for more than half of the total cellular transcripts depending on organism and growth condition. To support this level of expression, eukaryotic rRNA genes are present in multiple copies.
Stephan Hamperl +5 more
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Circular ribosomal DNA and ribosomal DNA: replication in somatic amphibian cells
Chromosoma, 1975Pulse labelled rDNA from cultured somatic cells of Xenopus laevis was examined by electron microscope autoradiography. The pattern of replication closely resembles that of bulk chromosomal DNA and differs considerably from rDNA synthesis during amplification in the oocyte.
J D, Rochaix, A P, Bird
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Heterogeneity in cucumber ribosomal DNA
Theoretical and Applied Genetics, 1986Restriction and hybridization analysis of cucumber native ribosomal (r) DNA purified from actinomycin-D/CsCl gradients suggested that the repeat units were heterogeneous in both length and sequence. Several full length rDNA repeat units were cloned and five are described which account for all the EcoR I and Xba I fragments present in native DNA. One of
T A, Kavanagh, J N, Timmis
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Ribosomal DNA of Caenorhabditis elegans
Journal of Molecular Biology, 1981Abstract We have characterized the organization of the genes coding for 18 S, 5·8 S and 26 S ribosomal RNAs in the nematode Caenorhabditis elegans . These ribosomal genes, present in about 55 copies per haploid genome, alternate in a repeating tandem array.
J G, Files, D, Hirsh
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Molecular Ecology Resources, 2019
Complete plastid genome (plastome) sequences and nuclear ribosomal DNA (nrDNA) regions have been proposed as candidates for the next generation of DNA barcodes for plant species discrimination.
Yunheng Ji +7 more
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Complete plastid genome (plastome) sequences and nuclear ribosomal DNA (nrDNA) regions have been proposed as candidates for the next generation of DNA barcodes for plant species discrimination.
Yunheng Ji +7 more
semanticscholar +1 more source
Nature, 1969
THE amount of DNA complementary to ribosomal RNA (rDNA) has been shown to be constant in several tissues varying in rRNA synthesis1,2. There is, however, a dramatic exception to this in amphibian and insect oocytes3–5, where amplification of the rDNA occurs and results in high rates of rRNA synthesis during oogenesis6.
J, Mohan, A, Dunn, L, Casola
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THE amount of DNA complementary to ribosomal RNA (rDNA) has been shown to be constant in several tissues varying in rRNA synthesis1,2. There is, however, a dramatic exception to this in amphibian and insect oocytes3–5, where amplification of the rDNA occurs and results in high rates of rRNA synthesis during oogenesis6.
J, Mohan, A, Dunn, L, Casola
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Non-canonical DNA structures in the human ribosomal DNA
Histochemistry and Cell Biology, 2023Non-canonical structures (NCS) refer to the various forms of DNA that differ from the B-conformation described by Watson and Crick. It has been found that these structures are usual components of the genome, actively participating in its essential functions.
Evgeny, Smirnov +4 more
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