Results 301 to 310 of about 534,315 (335)

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons   +17 more
wiley   +1 more source
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Circular ribosomal DNA and ribosomal DNA: replication in somatic amphibian cells

Chromosoma, 1975
Pulse labelled rDNA from cultured somatic cells of Xenopus laevis was examined by electron microscope autoradiography. The pattern of replication closely resembles that of bulk chromosomal DNA and differs considerably from rDNA synthesis during amplification in the oocyte.
J D, Rochaix, A P, Bird
openaire   +2 more sources

Heterogeneity in cucumber ribosomal DNA

Theoretical and Applied Genetics, 1986
Restriction and hybridization analysis of cucumber native ribosomal (r) DNA purified from actinomycin-D/CsCl gradients suggested that the repeat units were heterogeneous in both length and sequence. Several full length rDNA repeat units were cloned and five are described which account for all the EcoR I and Xba I fragments present in native DNA. One of
T A, Kavanagh, J N, Timmis
openaire   +2 more sources

Ribosomal DNA of Caenorhabditis elegans

Journal of Molecular Biology, 1981
Abstract We have characterized the organization of the genes coding for 18 S, 5·8 S and 26 S ribosomal RNAs in the nematode Caenorhabditis elegans . These ribosomal genes, present in about 55 copies per haploid genome, alternate in a repeating tandem array.
J G, Files, D, Hirsh
openaire   +2 more sources

Ribosomal DNA in the Rat

Nature, 1969
THE amount of DNA complementary to ribosomal RNA (rDNA) has been shown to be constant in several tissues varying in rRNA synthesis1,2. There is, however, a dramatic exception to this in amphibian and insect oocytes3–5, where amplification of the rDNA occurs and results in high rates of rRNA synthesis during oogenesis6.
J, Mohan, A, Dunn, L, Casola
openaire   +2 more sources

Non-canonical DNA structures in the human ribosomal DNA

Histochemistry and Cell Biology, 2023
Non-canonical structures (NCS) refer to the various forms of DNA that differ from the B-conformation described by Watson and Crick. It has been found that these structures are usual components of the genome, actively participating in its essential functions.
Evgeny, Smirnov   +4 more
openaire   +2 more sources

Circular ribosomal DNA during ribosomal magnification in Drosophila melanogaster

Journal of Molecular Biology, 1977
DNA from excised testes of Drosophila melanogaster males undergoing ribosomal DNA magnification shows two peaks on an ethidium bromide/CsCl density gradient: a minor peak that bands to a density of 1·570 g/cm3 and a main peak corresponding to 1·540 g/cm3 density.
F. GRAZIANI   +2 more
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Structure and organization of ribosomal DNA

Biochimie, 1991
Three trends are seen in the organization of ribosomal DNA genes during evolution: 1) gradual separation and separability of the regulation of transcription of 5S and larger subunit rRNAs; 2) retention of a transcription unit containing both large and small rRNAs; and 3) clustering of genes for both 5S and 18S-28S rDNAs, with the possible association ...
A K, Srivastava, D, Schlessinger
openaire   +2 more sources

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