Results 71 to 80 of about 59,620 (205)

Candidates in Astroviruses, Seadornaviruses, Cytorhabdoviruses and Coronaviruses for +1 frame overlapping genes accessed by leaky scanning [PDF]

, 2010
Background Overlapping genes are common in RNA viruses where they serve as a mechanism to optimize the coding potential of compact genomes. However, annotation of overlapping genes can be difficult using conventional gene-finding software.
Andrew E Firth, John F Atkins, AE Firth, AE Firth, BYW Chung, AE Firth, AE Firth, E Balmori Melian, R Belshaw, B Jiang, MM Willcocks, C Touriol, SR Finkbeiner, HC Zhu, R Rivera, A Kapoor, SS Monroe, SA Sedman, M Kozak, TL Lewis, U Geigenmüller, H Attoui, H Attoui, H Attoui, F Mohd Jaafar, D Matsuda, H Attoui, T Wetzel, RG Dietzgen, F Heim, JN Barr, CP Joshi, IK Jordan, C Rancurel, AE Gorbalenya, AO Pasternak, SD Senanayake, PC Woo, BQ Dong, ML Powell, DK Chu, SF Altschul, MA Larkin, P Rice   +43 more
core   +2 more sources

Mutation type‐specific transcriptomic signatures and readthrough therapy rescue in SMC1A‐related developmental and epileptic encephalopathy

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to investigate the molecular consequences of pathogenic variants in the SMC1A gene—particularly those associated with developmental and epileptic encephalopathy (DEE85)—and to evaluate the therapeutic potential of ataluren in restoring SMC1A function and mitigating disease‐related transcriptomic and genomic ...
Maddalena Di Nardo, Francesca Sardina, Maria M. Pallotta, Iñigo Marcos‐Alcalde, Paulino Gómez‐Puertas, Cinzia Rinaldo, Ian D. Krantz, Antonio Musio   +7 more
wiley   +1 more source

The genome and proteome of the Kluyvera bacteriophage Kvp1 – another member of the T7-like Autographivirinae [PDF]

, 2008
BACKGROUND: Kluyvera, a genus within the family Enterobacteriaceae, is an infrequent cause of human infections. Bacteriophage Kvp1, the only bacteriophage isolated for one of its species, Kluyvera cryocrescens, is a member of the viral family Podoviridae.
Erika J Lingohr, Andre Villegas, Yi-Min She, Pieter-Jan Ceyssens, Andrew M Kropinski   +4 more
core   +2 more sources

A Data‐Driven Redefinition of Early Relapse in Pediatric T Cell Acute Lymphoblastic Leukemia: Evidence for Progression of Disease 15 Months

Med Research, EarlyView.
Data‐driven redefinition of early relapse in pediatric T‐ALL using hazard modeling, cumulative incidence, and time‐dependent HR across 1533 patients in three independent cohorts identifies 15 months as the optimal threshold. By integrating temporal risk metrics and external validation, this study provides evidence for POD ≤ 15 months as a data‐driven ...
Na Zhang, Wenli Tang, Yali Shen, Yance Feng, Hui Shi, Binjun Xiong, Hua You   +6 more
wiley   +1 more source

Direct measurement of the mechanical work during translocation by the ribosome. [PDF]

, 2014
A detailed understanding of tRNA/mRNA translocation requires measurement of the forces generated by the ribosome during this movement. Such measurements have so far remained elusive and, thus, little is known about the relation between force and ...
Alexander, Lisa, BUSTAMANTE, Carlos J., Fredrick, Kurt, Kaplan, Ariel, Lancaster, Laura, Liu, Tingting, Noller, Harry, Tinoco, Ignacio, Wen, Jin-Der, Wickersham, Charles, Yan, Shannon   +10 more
core   +2 more sources

Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean‐Like Transgenic Mouse Model

Integrative Zoology, EarlyView.
UCP1 inactivation of cetaceans in mice drives BAT whitening and iWAT hyperplasia, promoting fat accumulation for aquatic adaptation. Abstract Cetaceans possess thick blubber, a specialized adipose tissue essential for thermal insulation, a streamlined body form, energy storage, and buoyancy. However, the mechanisms that underpin this adaptation are not
Qian Zhang, Yuehua Wang, Hang Zhang, Guiping Xu, Shixia Xu, Guang Yang   +5 more
wiley   +1 more source

V, 2.Ribosomal frameshifting in astroviruses

, 2003
This chapter reviews ribosomal frameshifting with an emphasis on the frameshifting process in astroviruses. Frameshifting is a potential antiviral target. It is possible that the replication cycle of any virus that uses this process could be disrupted by modulation of frameshift efficiencies, but a better understanding of the occurrence and the ...
Brierley, Ian, Vidakovic, Marijana
openaire   +2 more sources

Influence of the relA gene on ribosome frameshifting [PDF]

Molecular Genetics and Genomics, 2002
We have examined the influence of genotype at the relA locus on the kinetics of leftward (or -1) frameshifting at a variety of codons calling for a limiting aminoacyl-tRNA species. We used lacZ left-frameshift reporter constructs carrying the sequenceU UUC XYZ, whereXYZ was each of three triplets coding for three different amino acids; we slowed the ...
Masucci, J., Gallant, J., Lindsley, D., Atkinson, J.   +3 more
openaire   +2 more sources

The Molecular Diagnosis of Myopathies: Integrating Genomic, Proteomic, and Pathological Insights Toward Precision Medicine

Clinical Genetics, EarlyView.
Advances in genomic, proteomic, and transcriptomic technologies are transforming the diagnosis of genetic myopathies. When integrated with traditional muscle pathology, multi‐omics approaches improve diagnostic yield, clarify disease mechanisms, and support more precise, mechanism‐based therapeutic strategies for patients with neuromuscular disorders ...
Ludmila Alem, Denise de Abreu Pereira, Katia Carneiro   +2 more
wiley   +1 more source

An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response [PDF]

, 2012
Influenza A virus (IAV) infection leads to variable and imperfectly understood pathogenicity. We report that segment 3 of the virus contains a second open reading frame (‘X-ORF’), accessed via ribosomal frameshifting. The frameshift product, termed PA-X,
Atkins, J. F., Bell, G. L., Dalton, R. M., Digard, P., Dunfee, R. L., Efstathiou, S., Firth, A. E., Jagger, B. W., Kash, J. C., Lo, A., Ozinsky, A., Schwartzman, L. M., Taubenberger, J. K., Walters, K. A., Wills, N. M., Wise, H. M., Xiao, Y. L.   +16 more
core   +1 more source