Results 1 to 10 of about 394,012 (302)

Protein-inducible ribosomal frameshifting enables programmable translational control for genetic circuit design in Escherichia coli [PDF]

Journal of Biological Engineering
Background Programmed ribosomal frameshifting (PRF) is a translational mechanism that enables the ribosome to shift reading frames and access alternative coding sequences.
Seongho Hong, Yelin Lim, Hansol Kang, Jongmin Kim   +3 more
doaj   +2 more sources

An RNA modification prevents extended codon-anticodon interactions from facilitating +1 frameshifting [PDF]

Nature Communications
RNA post-transcriptional modifications act by stabilizing the functional conformations of RNA. While their role in messenger RNA (mRNA) decoding is well established, it is less clear how transfer RNA (tRNA) modifications outside the anticodon contribute ...
Evelyn M. Kimbrough, Ha An Nguyen, Haixing Li, Jacob M. Mattingly, Nevette A. Bailey, Wei Ning, Howard Gamper, Ya-Ming Hou, Ruben L. Gonzalez, Christine M. Dunham   +9 more
doaj   +2 more sources

Evolutionary origin of the frameshift sites in the ribosomal frameshifting genes of Euplotes [PDF]

BMC Genomics
Background Programmed ribosome frameshifting is a translational recoding event in which ribosomes slip forward or backward along the mRNA. Although genes utilizing programmed ribosomal frameshifting for their expression have been found in most organisms,
Ruan-lin Wang, Xiao-yan Liu, Qing-yao Meng, Xin Zhang, Yue-jun Fu, Ai-hua Liang   +5 more
doaj   +2 more sources

Stem loop binding protein promotes SARS-CoV-2 replication via -1 programmed ribosomal frameshifting [PDF]

Signal Transduction and Targeted Therapy
The -1 programmed ribosomal frameshifting (-1 PRF) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for keeping the balance between pp1a and pp1ab polyproteins.
Tanxiu Chen, Ruimin Zhu, Tingfu Du, Hao Yang, Xintian Zhang, Zhixing Wang, Yong Zhang, Wenqi Quan, Bin Yin, Yunpeng Liu, Shuaiyao Lu, Xiaozhong Peng   +11 more
doaj   +2 more sources

Thinking Outside the Frame: Impacting Genomes Capacity by Programmed Ribosomal Frameshifting

Frontiers in Molecular Biosciences, 2022
Translation facilitates the transfer of the genetic information stored in the genome via messenger RNAs to a functional protein and is therefore one of the most fundamental cellular processes.
Ricarda J. Riegger, Ricarda J. Riegger, Neva Caliskan, Neva Caliskan   +3 more
doaj   +1 more source

Investigating the correlation between Xrn1-resistant RNAs and frameshifter pseudoknots

RNA Biology, 2023
Xrn1-resistant RNA structures are multifunctional elements employed by an increasing number of RNA viruses. One of such elements is the coremin motif, discovered in plant virus RNAs, of which the structure has been hypothesized to form a yet unelucidated
Ivar W. Dilweg, Megan G. Oskam, Sophie Overbeek, René C.L. Olsthoorn   +3 more
doaj   +1 more source

Shiftless Is a Novel Member of the Ribosome Stress Surveillance Machinery That Has Evolved to Play a Role in Innate Immunity and Cancer Surveillance

Viruses, 2023
A longstanding paradox in molecular biology has centered on the question of how very long proteins are synthesized, despite numerous measurements indicating that ribosomes spontaneously shift reading frame at rates that should preclude their ability ...
Jamie A. Kelly, Jonathan D. Dinman
doaj   +1 more source

Regulation of programmed ribosomal frameshifting by co-translational refolding RNA hairpins. [PDF]

PLoS ONE, 2013
RNA structures are unwound for decoding. In the process, they can pause the elongating ribosome for regulation. An example is the stimulation of -1 programmed ribosomal frameshifting, leading to 3' direction slippage of the reading-frame during ...
Che-Pei Cho, Szu-Chieh Lin, Ming-Yuan Chou, Hsiu-Ting Hsu, Kung-Yao Chang   +4 more
doaj   +1 more source

Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation

Nature Communications, 2021
Translational frameshifting is a mechanism that expands the coding capabilities of mRNA. Here, structures of 70S ribosome complexes with GTPase elongation factor G (EF-G), a +1-frameshifting-prone mRNA and tRNAs reveal the cooperation between the ...
Gabriel Demo, Howard B. Gamper, Anna B. Loveland, Isao Masuda, Christine E. Carbone, Egor Svidritskiy, Ya-Ming Hou, Andrei A. Korostelev   +7 more
doaj   +1 more source

A Novel Frameshifting Inhibitor Having Antiviral Activity against Zoonotic Coronaviruses

Viruses, 2021
Recent outbreaks of zoonotic coronaviruses, such as Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have caused tremendous casualties and great economic shock.
Dae-Gyun Ahn, Gun Young Yoon, Sunhee Lee, Keun Bon Ku, Chonsaeng Kim, Kyun-Do Kim, Young-Chan Kwon, Geon-Woo Kim, Bum-Tae Kim, Seong-Jun Kim   +9 more
doaj   +1 more source