Results 31 to 40 of about 394,012 (302)

Model of the pathway of −1 frameshifting: Long pausing

Biochemistry and Biophysics Reports, 2016
It has been characterized that the programmed ribosomal −1 frameshifting often occurs at the slippery sequence on the presence of a downstream mRNA pseudoknot. In some prokaryotic cases such as the dnaX gene of Escherichia coli, an additional stimulatory
Ping Xie
doaj   +1 more source

Data mining in bioinformatics using Weka [PDF]

, 2004
The Weka machine learning workbench provides a general purpose environment for automatic classification, regression, clustering and feature selection-common data mining problems in bioinformatics research.
Frank, Eibe, Hall, Mark A., Holmes, Geoffrey, Trigg, Leonard E., Witten, Ian H.   +4 more
core   +3 more sources

A frameshift in time

eLife, 2022
The efficiency with which ribosomes shift reading frames when decoding viral RNA may change over the course of an infection.
Martina M Yordanova, Pavel V Baranov
openaire   +3 more sources

Molecular Dynamics Simulations Suggest a Non-Doublet Decoding Model of −1 Frameshifting by tRNA^Ser3

Biomolecules, 2019
In-frame decoding in the ribosome occurs through canonical or wobble Watson−Crick pairing of three mRNA codon bases (a triplet) with a triplet of anticodon bases in tRNA.
Thomas Caulfield, Matt Coban, Alex Tek, Samuel Coulbourn Flores   +3 more
doaj   +1 more source

Characterization of Ribosomal Frameshifting in Theiler's Murine Encephalomyelitis Virus. [PDF]

, 2015
Theiler's murine encephalomyelitis virus (TMEV) is a member of the genus Cardiovirus in the Picornaviridae, a family of positive-sense single-stranded RNA viruses. Previously, we demonstrated that in the related cardiovirus, Encephalomyocarditis virus, a
Bell, Susanne, Brierley, Ian, Finch, Leanne K, Firth, Andew E, Lardinois, Cécile, Ling, Roger, Loughran, Gary, Michiels, Thomas, Napthine, Sawsan, Olspert, Allan   +9 more
core   +2 more sources

CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication

Cell Reports, 2023
Summary: During translation of the genomic RNA of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative virus in the COVID-19 pandemic, host ribosomes undergo programmed ribosomal frameshifting (PRF) at a conserved structural ...
Frederick Rehfeld, Jennifer L. Eitson, Maikke B. Ohlson, Tsung-Cheng Chang, John W. Schoggins, Joshua T. Mendell   +5 more
doaj   +1 more source

Transcriptional frameshifting rescues Citrobacter rodentium Type VI secretion by the production of two length variants from the prematurely interrupted tssM gene [PDF]

, 2013
The Type VI secretion system (T6SS) mediates toxin delivery into both eukaryotic and prokaryotic cells. It is composed of a cytoplasmic structure resembling the tail of contractile bacteriophages anchored to the cell envelope through a membrane complex ...
Atkins, John F., Cascales, Eric, Gueguen, Erwan, Wills, Norma M.   +3 more
core   +4 more sources

Identification of the nature of reading frame transitions observed in prokaryotic genomes [PDF]

, 2013
Our goal was to identify evolutionary conserved frame transitions in protein coding regions and to uncover an underlying functional role of these structural aberrations.
Antonov, Ivan, Atkins, John F., Baranov, Pavel V., Borodovsky, Mark, Coakley, Arthur   +4 more
core   +1 more source

Modulation of Viral Programmed Ribosomal Frameshifting and Stop Codon Readthrough by the Host Restriction Factor Shiftless

Viruses, 2021
The product of the interferon-stimulated gene C19orf66, Shiftless (SHFL), restricts human immunodeficiency virus replication through downregulation of the efficiency of the viral gag/pol frameshifting signal.
Sawsan Napthine, Chris H. Hill, Holly C. M. Nugent, Ian Brierley   +3 more
doaj   +1 more source

Transcription-translation coupling: direct interactions of RNA polymerase with ribosomes and ribosomal subunits. [PDF]

, 2017
In prokaryotes, RNA polymerase and ribosomes can bind concurrently to the same RNA transcript, leading to the functional coupling of transcription and translation.
Blaha, Gregor M, Conn, Adam B, Diggs, Stephen, Fan, Haitian, Gamper, Howard B, Hahm, Joseph, Hou, Ya-Ming, O'Leary, Seán E, Wang, Yinsheng, Williams, Preston B   +9 more
core   +1 more source