Results 21 to 30 of about 394,012 (302)

The highly conserved codon following the slippery sequence supports -1 frameshift efficiency at the HIV-1 frameshift site. [PDF]

PLoS ONE, 2015
HIV-1 utilises -1 programmed ribosomal frameshifting to translate structural and enzymatic domains in a defined proportion required for replication. A slippery sequence, U UUU UUA, and a stem-loop are well-defined RNA features modulating -1 frameshifting
Suneeth F Mathew, Caillan Crowe-McAuliffe, Ryan Graves, Tony S Cardno, Cushla McKinney, Elizabeth S Poole, Warren P Tate   +6 more
doaj   +1 more source

Translational Frameshifting in the chlD Gene Gives a Clue to the Coevolution of the Chlorophyll and Cobalamin Biosyntheses

Microorganisms, 2022
Today, hundreds of prokaryotic species are able to synthesize chlorophyll and cobalamin (vitamin B12). An important step in the biosynthesis of these coenzymes is the insertion of a metal ion into a porphyrin ring. Namely, Mg-chelatase ChlIDH and aerobic
Stepan Kuznetsov, Alexander Milenkin, Ivan Antonov   +2 more
doaj   +1 more source

A three-stemmed mRNA pseudoknot in the SARS coronavirus frameshift signal. [PDF]

PLoS Biology, 2005
A wide range of RNA viruses use programmed -1 ribosomal frameshifting for the production of viral fusion proteins. Inspection of the overlap regions between ORF1a and ORF1b of the SARS-CoV genome revealed that, similar to all coronaviruses, a programmed -
Ewan P Plant, Gabriela C Pérez-Alvarado, Jonathan L Jacobs, Bani Mukhopadhyay, Mirko Hennig, Jonathan D Dinman   +5 more
doaj   +1 more source

Monovalent ions modulate the flux through multiple folding pathways of an RNA pseudoknot [PDF]

, 2017
The functions of RNA pseudoknots (PKs), which are minimal tertiary structural motifs and an integral part of several ribozymes and ribonucleoprotein complexes, are determined by their structure, stability and dynamics.
Ansari, Anjum, Baral, Saroj, Hori, Naoto, Narayanan, Prasanth, Narayanan, Ranjani, Roca, Jorjethe, Thirumalai, D., Velmurugu, Yogambigai   +7 more
core   +3 more sources

PROGRAMMED TRANSLATIONAL FRAMESHIFTING [PDF]

Annual Review of Genetics, 1996
▪ Abstract  Errors that alter the reading frame occur extremely rarely during translation, yet some genes have evolved sequences that efficiently induce frameshifting. These sequences, termed programmed frameshift sites, manipulate the translational apparatus to promote non-canonical decoding. Frameshifts are mechanistically diverse.
openaire   +3 more sources

Programmed Deviations of Ribosomes From Standard Decoding in Archaea

Frontiers in Microbiology, 2021
Genetic code decoding, initially considered to be universal and immutable, is now known to be flexible. In fact, in specific genes, ribosomes deviate from the standard translational rules in a programmed way, a phenomenon globally termed recoding ...
Federica De Lise, Andrea Strazzulli, Andrea Strazzulli, Roberta Iacono, Roberta Iacono, Nicola Curci, Nicola Curci, Mauro Di Fenza, Luisa Maurelli, Marco Moracci, Marco Moracci, Marco Moracci, Beatrice Cobucci-Ponzano   +12 more
doaj   +1 more source

Programmed −1 ribosomal frameshifting from the perspective of the conformational dynamics of mRNA and ribosomes

Computational and Structural Biotechnology Journal, 2021
Programmed −1 ribosomal frameshifting (−1 PRF) is a translation mechanism that regulates the relative expression level of two proteins encoded on the same messenger RNA (mRNA).
Kai-Chun Chang, Jin-Der Wen
doaj   +1 more source

HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation. [PDF]

, 2013
The internal ribosome entry site (IRES) of the hepatitis C virus (HCV) drives noncanonical initiation of protein synthesis necessary for viral replication.
A Ben-Shem, A Devaraj, AA Malygin, AD Petropoulos, AY Keel, Breanna S Vollmar, C Chen, CM Spahn, CS Fraser, CS Fraser, D Boehringer, D Hartz, D Sousa, Dan Shi, DD Ian'shina, DV Sizova, EF Pettersen, F Odreman-Macchioli, F Peske, F Robert, GA Otto, GJ Kleywegt, H Ji, IB Lomakin, IM Terenin, J Bukh, J Rabl, J Wower, JA Mindell, JE Wilson, Jeffrey S Kieft, JH Kim, JM Fringer, JR Lytle, JR Lytle, JS Kieft, JS Kieft, K Tsukiyama-Kohara, KE Berry, KI Kalliampakou, LA Passmore, M Honda, M Ohi, M Selmer, M Stoneley, M van Heel, ME Filbin, Megan E Filbin, MG Acker, MM Yusupov, N Grigorieff, N Locker, O Galkin, P Antúnez de Mayolo, P Simmonds, PJ Lukavsky, PJ Lukavsky, RE Monro, RJ Jackson, S Fukushi, S Uemura, SM Dibrov, T Döring, Tamir Gonen, TV Pestova, TV Pestova, U Geigenmüller, VG Kolupaeva, Y Yu   +68 more
core   +1 more source

Altering SARS Coronavirus Frameshift Efficiency Affects Genomic and Subgenomic RNA Production

Viruses, 2013
In previous studies, differences in the amount of genomic and subgenomic RNA produced by coronaviruses with mutations in the programmed ribosomal frameshift signal of ORF1a/b were observed.
Ewan P. Plant, Deborah R. Taylor, Jonathan D. Dinman, Ralph S. Baric, Amy C. Sims   +4 more
doaj   +1 more source

HIV-1 and Human PEG10 Frameshift Elements Are Functionally Distinct and Distinguished by Novel Small Molecule Modulators.

PLoS ONE, 2015
Frameshifting during translation of viral or in rare cases cellular mRNA results in the synthesis of proteins from two overlapping reading frames within the same mRNA.
Tony S Cardno, Yosuke Shimaki, Brad E Sleebs, Kurt Lackovic, John P Parisot, Rebecca M Moss, Caillan Crowe-McAuliffe, Suneeth F Mathew, Christina D Edgar, Torsten Kleffmann, Warren P Tate   +10 more
doaj   +1 more source