Nature Communications, 2021 Programmed ribosomal frameshifting (PRF) occurs in many viruses including SARS-CoV-2 to allow the translation of multiple proteins from a single transcript.
Matthias M. Zimmer +8 more
doaj +1 more source
Salt Effects on the Thermodynamics of a Frameshifting RNA Pseudoknot under Tension
, 2016 Because of the potential link between -1 programmed ribosomal frameshifting and response of a pseudoknot (PK) RNA to force, a number of single molecule pulling experiments have been performed on PKs to decipher the mechanism of programmed ribosomal ...
Denesyuk, Natalia A. +2 more
core +1 more source
The evolution, distribution and diversity of endogenous circoviral elements in vertebrate genomes [PDF]
, 2018 Circoviruses (family Circoviridae) are small, non-enveloped viruses that have short, single-stranded DNA genomes. Circovirus sequences are frequently recovered in metagenomic investigations, indicating that these viruses are widespread, yet they remain ...
Dennis, Tristan P.W. +5 more
core +1 more source
Frameshifting in the P6 cDNA Phage Display System
Molecules, 2010 Phage display is a powerful technique that enables easy identification of targets for any type of ligand. Targets are displayed at the phage surface as a fusion protein to one of the phage coat proteins.
Veerle Somers +3 more
doaj +1 more source
Programmable modulation of ribosomal frameshifting by mRNA targeting CRISPR-Cas12a system
iScience, 2023 Summary: Minus 1 programmed ribosomal frameshifting (−1 PRF) is a conserved translational regulation event essential for critical biological processes, including the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication.
Shih-Hong Huang +4 more
doaj +1 more source
Mutations in the RB1 Gene in Argentine Retinoblastoma Patients and Uncommon Clinical Presentations [PDF]
, 2015 Background: Retinoblastoma, the most common ocular cancer of childhood, is caused by inactivation of the RB1 tumor suppressor gene in the developing retina.
Alonso, Cristina +6 more
core +1 more source
Predicting ribosomal frameshifting efficiency [PDF]
Physical Biology, 2008 Many retroviruses use -1 ribosomal frameshifting as part of the mechanism in translational control of viral protein synthesis. Quantitative prediction of the efficiency of -1 frameshifting is crucial for understanding the viral gene expression. Here we investigate the free energy landscape for a minimal -1 programmed ribosomal frameshifting machinery ...
Song, Cao, Shi-Jie, Chen
openaire +2 more sources
Synergetic regulation of translational reading-frame switch by ligand-responsive RNAs in mammalian cells [PDF]
, 2014 Distinct translational initiation mechanisms between prokaryotes and eukaryotes limit the exploitation of prokaryotic riboswitch repertoire for regulatory RNA circuit construction in mammalian application.
Chang, K.-Y., Hsu, H.-T., Lin, Y.-H.
core +1 more source
Thermodynamic control of −1 programmed ribosomal frameshifting
Nature Communications, 2019 Programmed ribosomal frameshifting (PRF) is an alternative translation strategy that causes controlled slippage of the ribosome along the mRNA, changing the sequence of the synthesized protein.
Lars V. Bock +5 more
doaj +1 more source
Rational design of a synthetic mammalian riboswitch as a ligand-responsive -1 ribosomal frame-shifting stimulator [PDF]
, 2016 Metabolite-responsive RNA pseudoknots derived from prokaryotic riboswitches have been shown to stimulate −1 programmed ribosomal frameshifting (PRF), suggesting −1 PRF as a promising gene expression platform to extend riboswitch applications in higher ...
Chang, Kung-Yao, Lin, Ya-Hui, 張功耀
core +1 more source