Results 11 to 20 of about 394,012 (302)
Ribosomal frameshifting used in influenza A virus expression occurs within the sequence UCC_UUU_CGU and is in the +1 direction [PDF]
Open Biology, 2012 Programmed ribosomal frameshifting is used in the expression of many virus genes and some cellular genes. In eukaryotic systems, the most well-characterized mechanism involves –1 tandem tRNA slippage on an X_XXY_YYZ motif.
A. E. Firth +9 more
doaj +4 more sources
Biopolymers, 2013 ABSTRACTTranslation of messenger RNA by a ribosome occurs three nucleotides at a time from start signal to stop. However, a frameshift means that some nucleotides are read twice or some are skipped, and the following sequence of amino acids is completely different from the sequence in the original frame.
Ignacio, Tinoco +2 more
openaire +2 more sources
FRAMESHIFTS AND FRAMESHIFT SUPPRESSORS IN SACCHAROMYCES CEREVISIAE [PDF]
Genetics, 1977 ABSTRACT Using ICR-170 as a mutagen, we have induced a set of mutations in yeast which exhibit behavior similar to that shown for bacterial frameshift mutations. Our genetic study shows that these mutations are polar; the polarity can be relieved by internal suppressors; they revert with acridine half-mustards and are not suppressed by ...
M R, Culbertson +3 more
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An astrovirus frameshift signal induces ribosomal frameshifting in vitro [PDF]
Archives of Virology, 1995 Expression of the astrovirus RNA-dependent RNA polymerase has been hypothesized to be regulated by (-1) ribosomal frameshifting. Sequence analysis of the 70 nucleotide region between open reading frames 1a and 1b indicates the presence of a shifty heptamer consensus sequence and downstream sequences that may be needed for ribosomal frameshifting.
Lewis, T. L., Matsui, S. M.
openaire +2 more sources
Bacterial riboproteogenomics : the era of N-terminal proteoform existence revealed [PDF]
, 2020 With the rapid increase in the number of sequenced prokaryotic genomes, relying on automated gene annotation became a necessity. Multiple lines of evidence, however, suggest that current bacterial genome annotations may contain inconsistencies and are ...
Fijalkowska, Daria +3 more
core +2 more sources
High-throughput interrogation of programmed ribosomal frameshifting in human cells
Nature Communications, 2020 Programmed ribosomal frameshifting—the slippage of the ribosome to an alternative frame — is critical for viral replication and cellular processes.
Martin Mikl, Yitzhak Pilpel, Eran Segal
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Biomolecules, 2022 Co-translational incorporation of selenocysteine (Sec) into selenoproteins occurs at UGA codons in a process in which translational elongation competes with translational termination. Selenocysteine insertion sequence-binding protein 2 (SECISBP2) greatly
Simon Bohleber +4 more
doaj +1 more source
mBio, 2022 The constrained nature of viral genomes has allowed a translational sleight of hand known as −1 Programmed Ribosomal Frameshifting (−1 PRF) to flourish. Numerous studies have sought to tease apart the mechanisms and implications of −1PRF utilizing a few ...
Wesley D. Penn, Suchetana Mukhopadhyay
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Active role of elongation factor G in maintaining the mRNA reading frame during translation. [PDF]
, 2019 During translation, the ribosome moves along the mRNA one codon at a time with the help of elongation factor G (EF-G). Spontaneous changes in the translational reading frame are extremely rare, yet how the precise triplet-wise step is maintained is not ...
Belardinelli, R. +5 more
core +2 more sources
On programmed ribosomal frameshifting: the alternative proteomes
Frontiers in Genetics, 2012 Frameshifting results from two main mechanisms: genomic insertions or deletions (indels) or programmed ribosomal frameshifting. Whereas indels can disrupt normal protein function, programmed ribosomal frameshifting can result in dual-coding genes, each ...
Robin eKetteler
doaj +1 more source