Results 51 to 60 of about 59,620 (205)
Synergetic regulation of translational reading-frame switch by ligand-responsive RNAs in mammalian cells [PDF]
, 2014 Distinct translational initiation mechanisms between prokaryotes and eukaryotes limit the exploitation of prokaryotic riboswitch repertoire for regulatory RNA circuit construction in mammalian application.
Chang, K.-Y., Hsu, H.-T., Lin, Y.-H.
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Programmed ribosomal frameshifting: Much ado about knotting! [PDF]
Proceedings of the National Academy of Sciences, 1999 We know little about the global contribution that recoding makes to the complexity of proteomes. It could be that many mRNAs encode, in addition to their standard products, minor products that so far would have escaped detection. These products are likely to have distinct functions and contribute to the biological complexity of the proteome.
S L, Alam, J F, Atkins, R F, Gesteland
openaire +2 more sources
Biology Direct, 2017 Background Programmed ribosomal frameshifting (PRF) is a gene expression mechanism which enables the translation of two N-terminally coincident, C-terminally distinct protein products from a single mRNA.
Adam M. Dinan +2 more
doaj +1 more source
Viruses, 2021 Many viruses, especially RNA viruses, utilize programmed ribosomal frameshifting and/or stop codon readthrough in their expression, and in the decoding of a few a UGA is dynamically redefined to specify selenocysteine.
John F. Atkins +3 more
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Structure of a Protozoan Virus from the Human Genitourinary Parasite Trichomonas vaginalis [PDF]
, 2013 The flagellated protozoan Trichomonas vaginalis is an obligate human genitourinary parasite and the most frequent cause of sexually transmitted disease worldwide. Most clinical isolates of T.
Asara, John M +10 more
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Mechanism of tRNA-mediated +1 ribosomal frameshifting [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance Accurate gene expression is essential in all organisms. During protein synthesis, transfer RNAs (tRNAs) decode the genetic information contained in messenger RNA (mRNA) on the ribosome into amino acids using a defined 3-nt code. A fundamental question in biology is how the ribosome maintains this 3-nt code, or mRNA frame, during ...
Samuel, Hong +5 more
openaire +2 more sources
The phenotype of many independently isolated +1 frameshift suppressor mutants supports a pivotal role of the P-site in reading frame maintenance. [PDF]
PLoS ONE, 2013 The main features of translation are similar in all organisms on this planet and one important feature of it is the way the ribosome maintain the reading frame.
Gunilla Jäger +2 more
doaj +1 more source
Rational design of a synthetic mammalian riboswitch as a ligand-responsive -1 ribosomal frame-shifting stimulator [PDF]
, 2016 Metabolite-responsive RNA pseudoknots derived from prokaryotic riboswitches have been shown to stimulate −1 programmed ribosomal frameshifting (PRF), suggesting −1 PRF as a promising gene expression platform to extend riboswitch applications in higher ...
Chang, Kung-Yao, Lin, Ya-Hui, 張功耀
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Model of the pathway of −1 frameshifting: Long pausing
Biochemistry and Biophysics Reports, 2016 It has been characterized that the programmed ribosomal −1 frameshifting often occurs at the slippery sequence on the presence of a downstream mRNA pseudoknot. In some prokaryotic cases such as the dnaX gene of Escherichia coli, an additional stimulatory
Ping Xie
doaj +1 more source
An Equilibrium-Dependent Retroviral mRNA Switch Regulates Translational Recoding [PDF]
, 2011 Most retroviruses require translational recoding of a viral messenger RNA stop codon to maintain a precise ratio of structural (Gag) and enzymatic (Pol) proteins during virus assembly.
D'Souza, Victoria M +6 more
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