Results 31 to 40 of about 59,620 (205)
The energy landscape of -1 ribosomal frameshifting. [PDF]
Sci Adv, 2020 During translation, the presence of an mRNA structure prolongs a ribosomal state favorable to spontaneous frameshifting.
Choi J +3 more
europepmc +5 more sources
An astrovirus frameshift signal induces ribosomal frameshifting in vitro [PDF]
Archives of Virology, 1995 Expression of the astrovirus RNA-dependent RNA polymerase has been hypothesized to be regulated by (-1) ribosomal frameshifting. Sequence analysis of the 70 nucleotide region between open reading frames 1a and 1b indicates the presence of a shifty heptamer consensus sequence and downstream sequences that may be needed for ribosomal frameshifting.
Lewis, T. L., Matsui, S. M.
openaire +2 more sources
Nature Communications, 2021 Programmed ribosomal frameshifting (PRF) occurs in many viruses including SARS-CoV-2 to allow the translation of multiple proteins from a single transcript.
Matthias M. Zimmer +8 more
doaj +1 more source
Deciphering Ribosomal Frameshifting Dynamics [PDF]
Biophysical Journal, 2012 Ribosomes programmed by specific messenger RNA (mRNA) sequence elements can switch translation reading frames and synthesize different polypeptides from a single template. The Escherichia coli dnaX mRNA encodes two DNA polymerase III subunits, τ and γ, synthesized from 0-frame and probabilistic −1-slip across the slippery sequence: AAAAAAG.
Yan, Shannon +5 more
openaire +2 more sources
Active role of elongation factor G in maintaining the mRNA reading frame during translation. [PDF]
, 2019 During translation, the ribosome moves along the mRNA one codon at a time with the help of elongation factor G (EF-G). Spontaneous changes in the translational reading frame are extremely rare, yet how the precise triplet-wise step is maintained is not ...
Belardinelli, R. +5 more
core +2 more sources
KnotInFrame: prediction of −1 ribosomal frameshift events [PDF]
Nucleic Acids Research, 2008 Programmed -1 ribosomal frameshift (-1 PRF) allows for alternative reading frames within one mRNA. First found in several viruses, it is now believed to exist in all kingdoms of life. Strong stimulators for -1 PRF are a heptameric slippery site and an RNA pseudoknot.
Theis, Corinna +2 more
openaire +3 more sources
Nature Communications, 2021 The RNA pseudoknot of SARS-CoV-2 promotes -1 programmed ribosomal frameshifting. Here the authors use single molecule force spectroscopy to study the folding of this pseudoknot, showing that it forms at least two different pseudoknot conformers with ...
Krishna Neupane +8 more
doaj +1 more source
A Novel Frameshifting Inhibitor Having Antiviral Activity against Zoonotic Coronaviruses
Viruses, 2021 Recent outbreaks of zoonotic coronaviruses, such as Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have caused tremendous casualties and great economic shock.
Dae-Gyun Ahn +9 more
doaj +1 more source
Monovalent ions modulate the flux through multiple folding pathways of an RNA pseudoknot [PDF]
, 2017 The functions of RNA pseudoknots (PKs), which are minimal tertiary structural motifs and an integral part of several ribozymes and ribonucleoprotein complexes, are determined by their structure, stability and dynamics.
Ansari, Anjum +7 more
core +3 more sources
HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation. [PDF]
, 2013 The internal ribosome entry site (IRES) of the hepatitis C virus (HCV) drives noncanonical initiation of protein synthesis necessary for viral replication.
A Ben-Shem +68 more
core +1 more source